The main objective of the this study was to formulate, develop and evaluate a Transdermal drug delivery system containing Metformin hydrochloride to overcome the critical problems related with oral route. Transdermal patch of Metformin hydrochloride were prepared using solvent evaporation technique. Different trial of formulation were carried out by changing the polymer ratio. Transdermal Patch formulations were characterized for Thickness, weight variation, Percentage Moisture content, Folding endurance, Assay and In vitro drug release studies. In-vitro drug release study and evaluation were carried out for formulation No. F1-F7. Separately Drug and physical mixture were characterized by using FTIR, the result showed that between drug and polymers compatability.

Keywords : Transdemal Delivery, Metformin Hydrochloride, Topical Drug Delivery.