From Dreams to Dementia: Shedding Light on the Sleep-Lewy Body Dementia Connection


Authors : Dr. Niladri Dutta

Volume/Issue : Volume 8 - 2023, Issue 8 - August

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/372rpkts

DOI : https://doi.org/10.5281/zenodo.8255931

Abstract : Sleep constitutes a significant portion of human life, with individuals spending approximately one-third of their existence either sleeping or attempting to do so.1 Sleep is critical not only for its comforting effects but also for the maintenance of normal cognitive functioning and human survival. The phenomenon of sleep is complex, with the body unresponsive to cognitive impulses from external stimuli whilst the brain continues to function within various learning and memory-related regions. The time spent sleeping is vital for retaining memory, as it helps to stabilize and improve associations between synapses and various areas of the brain. Sleep is divided into two distinct stages, namely rapid-eye movement (REM) sleep and non- rapid-eye movement (NREM) sleep. Slow-wave sleep, the fourth stage of NREM sleep, is the deepest stage of sleep and promotes muscle and mental health restoration, as well as memory consolidation. 2 Acquisition, consolidation, and review are the three primary phases of learning and memory. Acquisition refers to the influx of new information into the brain, consolidation to the preservation of memory, and review to the ability to retrieve stored information. Consolidation of memories can only occur during sleep, according to numerous studies, and it does so through the neural networks that control memory. Additionally, different brainwave patterns are associated with the formation of different types of memories.

Keywords : Sleep-Lewy Body Dementia Connection, Disrupted Sleep, Lewy Body Dementia, Neurodegenerative Syndromes.

Sleep constitutes a significant portion of human life, with individuals spending approximately one-third of their existence either sleeping or attempting to do so.1 Sleep is critical not only for its comforting effects but also for the maintenance of normal cognitive functioning and human survival. The phenomenon of sleep is complex, with the body unresponsive to cognitive impulses from external stimuli whilst the brain continues to function within various learning and memory-related regions. The time spent sleeping is vital for retaining memory, as it helps to stabilize and improve associations between synapses and various areas of the brain. Sleep is divided into two distinct stages, namely rapid-eye movement (REM) sleep and non- rapid-eye movement (NREM) sleep. Slow-wave sleep, the fourth stage of NREM sleep, is the deepest stage of sleep and promotes muscle and mental health restoration, as well as memory consolidation. 2 Acquisition, consolidation, and review are the three primary phases of learning and memory. Acquisition refers to the influx of new information into the brain, consolidation to the preservation of memory, and review to the ability to retrieve stored information. Consolidation of memories can only occur during sleep, according to numerous studies, and it does so through the neural networks that control memory. Additionally, different brainwave patterns are associated with the formation of different types of memories.

Keywords : Sleep-Lewy Body Dementia Connection, Disrupted Sleep, Lewy Body Dementia, Neurodegenerative Syndromes.

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