Gallbladder Metastasis from Breast Cancer: A Case Report

Authors : Zineb Kabala; Mouna Bourhafour; Zineb Bouchbika; Nadia Benchekroun; Hassan Jouhadi; Tawfiq Nezha; Souha Sahraoui

Volume/Issue : Volume 8 - 2023, Issue 7 - July

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Mestatic breast carcinoma to the gallbladder is uncommon. We report the case of a 50-year-old female woman whose history of the disease dates back to 2018 with diagnosis of right breast luminal B ductal carcinoma.The patient underwent a Patey then referred to the radiation oncology department for further management.A thoraco-abdominopelvic CT scan performed prior to adjuvant treatment revealed the presence of two secondary hepatic nodules.A hepatic MRI was performed revealing two nodular hepatic lesions in favor of angiomas. The RCP decision was made to begin adjuvant treatment with hepatic lesion monitoring. The patient ends her therapy in 2019, with the hepatic lesions disappearing on the surveillance CT scan, and was put on tamoxifen with close hepatic monitoring.An abdominal ultrasound in February 2020 revealed tiny sections of segment VI and domes and no worrisome focal lesions; an abdominal MRI scan was ordered, which revealed a liver with two nodular forms, segment VII and segment VI, as well as two millimetric nodules.The liver biopsy (PBF) demonstrated luminal B ductal carcinoma hepatic location congruent with mammary origin.A CT scan revealed a liver filled with lesions, a swollen gall bladder with two macrolithiasis lesions and osteocondensing lesions, CA 15.3 at 1132 U/ml, and bone scintigraphy showing hyperfixation of the base of the skull, vertebral, iliac, right femoral, and right tibial.The RCP considered the matter again and agreed to put the patient on first-line therapy antiCD4/6 with letrozole.Two months after the patient went to the emergency for acute cholecystit a laparoscopic cholecystectomy was conducted. Anathomo pathological examination of the specimen shows a perivesicular immune histochemical appearance of a poorly differentiated mammary carcinoma compatible with the luminal B ductal mammary carcinoma. In view of the progression, the patient was transferred to 2nd-line and a new extended work-up were sought, but she died seven days after the appointment.

Keywords : Breast cancer, ductal carcinoma, gallbladder, acute cholecystit , laparoscopic cholecystectomy


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30 - November - 2023

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