The HFE gene is present in the genome of various organisms, including Homo sapiens and functions to regulate the amount of iron in the body. With speciation, HFE gene has evolved in the various organisms but organisms having the common ancestry still have the HFE protein structure similar to the ancestral homologues. This has been proved and the applications to this have been extrapolated in this paper. This paper has therefore hypothesized a likely source of the transgenic HFE gene for gene therapy and other therapies that are under development. Besides the hypothesis of transgenic HFE source, the paper also shows the relation of Homo sapiens with its Primate ancestors such as Gorilla gorilla and Pan troglodytes. The approach to the extrapolation of results was using the Basic Local Alignment Sequence Tool (BLAST) of the Homo sapiens HFE gene (NM_000410.4 Homo sapiens homeostatic iron regulator (HFE), transcript variant 1, mRNA) and then Pairwise alignment of the Closest genes to the Homo sapiens HFE gene. To further strengthen the claim, the Homo sapiens HFE protein was aligned with that of the closest genes that were found using BLAST. The results found that the Pan troglodytes HFE gene was close to 99.35% in identity to the Homo sapiens HFE, whereas Pan troglodytes protein had a 100% match to that of Homo sapiens HFE protein. Thus the chimpanzee HFE gene can act as a source for the transgenic genes for curing the Classic, Type-I hemochromatosis, wherein the HFE protein synthesized by the body is dysfunctional to regulate the Iron in the body as Iron sensing complex is rendered dysfunctional by the malformed HFE protein which leads to the high amount of iron in the body which causes various problems such as diabetes, liver cirrhosis and etc in the long run.

Keywords : Hemochromatosis, HFE Gene, HFE Protein, HFE Trans-Genesis.