Authors : Najla N. Al-Sonboli, Mabrook A. Bin Mohnna, Nasher A. Al-Aghbari, Zekra Al-Shaekh, Basheer Abo Asba
Volume/Issue : Volume 4 - 2019, Issue 12 - December
Google Scholar : https://goo.gl/DF9R4u
Scribd : https://bit.ly/37iBe59
Rotavirus gastroenteritis is an essential cause of
morbidity and mortality among under five years
children in the developing countries.
Determination of its incidence and serotypes.
It is a prospective cross-sectional study conducted
in a tertiary hospital in Sana' as part of regional
surveillance for rotavirus. Children <5 years with acute
diarrhea were eligible for enrollment. The stool samples
were collected and tested according to standard WHO
guideline. Rotavirus was tested using enzyme linked
immunoassay and the serotypes by PCR at the Regional
Rotavirus Reference Laboratory, Cairo, Egypt. The
data was processed and analyzed using Epi info
program (version, 2008).
The incidence rate of Rotavirus was 24.4%. G12
constitutes 45.5%, G2 constitutes 19.5%, G1, and G9
14% each and G3 2.6% of the samples. The genotyping
of P gene showed that P constitutes 78% of the
samples, P 17%, P 4%, and the un-typable (UT)
only 1% of the samples. The rate of G-P combinations
showed that G12P in thirty-four samples; G2P in
thirteen samples, G1P in eleven samples; G9P in
ten samples ; G[UT] P in three samples; G2P and
G3P in two samples each; and G9P in one sample.
The incidence rate of Rotavirus in Sana'a didn't
change much despite the introduction of the vaccine.
This could be attributed to the emergence of new
serotypes such G12 and G9 that were not covered by the
Rotarix vaccine. There will be a strong need to develop
a new vaccine that cover these new emerging serotypes.
Keywords : Rotavirus, Children, Serotypes, Sana'a.