Arthritis is a musculoskeletal system
disorder which involves destabilization of normal
mechanisms. Due to changing habits of living life, the
number of arthritic people will increase rapidly.
Currently, the existing anti-rheumatic drugs mostly
show side effects like acne, blurred vision, high blood
pressure and more effective to reduce pain and improve
disease conditions but still, they do not treat the disease
completely. Literature available indicates that most of
the people seek complementary alternative treatments
(CAM). Ginger (Zingiber officinale) has empirically
explored its use as an anti-inflammatory agent.
Amongst others, the Topical route of drug delivery has
built up popularity because it avoids first-pass effects,
metabolic breakdown associated with oral
administration and gastrointestinal irritation. Also, they
are less greasy and can be easily washed off from the
skin surface. The current study aimed to formulate antiarthritic gel containing ginger extract and to evaluate
its drug release activity. The topical ginger gels were
prepared using Carbopol 934 as a gelling agent with
varying concentrations, i.e., 0.5 %, 1 %, and 1.5 % w/w.
The gel was assayed to determine percent purity and
cumulative drug release. Results indicated that the 1.5
% w/w concentration of carbopol in ginger gel exhibited
an adequate drug release. In conclusion, an antiarthritic gel containing 1.5 % w/w of carbopol had a
good consistency, acceptable spreadability, and showed
a good drug release profile. The topical prepared herbal
ginger gel is a simple, easily formulated, convenient and
economical alternative that needs to be weighed in the
treatment of RA.
Keywords : Gel, Ginger, Arthritis, Topical dosage form, carbopol, drug release.