The use of medicinal plants as source of
health remedies in malaria endemic regions has
significantly increased as a result of increase malaria
parasite resistant to some synthetic drugs currently in
used. Extracts prepared from Piliostigma thonningii and
Lophira lanceolata leaves are used for curing malaria
and other related human diseases in Nigeria. The aim of
this study was to investigate the possible
haematotoxicity and histotoxicity profile of P. thonnigii
and L. lanceolata in Wistar albino rats. Graded doses of
Ethanolic extracts prepared from P. thonningii and L.
lanceolata leaves were administered day-to-day (1000,
1500 and 2000 mg/kg) orally to rats for 14 days
respectively and the effects on body weight, relative
organ weight, haematology, serum biochemical and
histopathology parameters were evaluated. The relative
weights of the sampled organs of treated rats were
unaffected. No significant deviations in haematological
profile of treated animals. Both extracts elicited
significant decline in BUN levels at 1000 mg/kg dose.
Histopathological findings reveal evidence of some mild
and focal lesions. This study indicates that P. thonnigii
and L. lanceolata leaves ethanolic extracts have no
obvious negative effects when applied orally under a
controlled dosage of 2000mg/ kg body weight. However,
the histopathological studies therefore calls for
watchfulness or caution to constant/repeated exposure
to the extracts.
Keywords : Piliostigma thonningii, Lophira lanceolata, haematotoxicity, histotoxicity, Wistar albino rats.