Authors :
Dr. Maya Mhaske; Dr. Qureshi Shifa Mahin; Dr. Mohammed Abdul Rafe; Dr. Shradhha Bhandari; Dr. Apurva Wakude; Dr. Samradnyee Shirolkar
Volume/Issue :
Volume 11 - 2026, Issue 7 - July
Google Scholar :
https://tinyurl.com/yvfkrdks
Scribd :
https://tinyurl.com/mryd7hm9
DOI :
https://doi.org/10.38124/ijisrt/26jul278
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Background
Halitosis affects 31.8% of adults globally[3] and periodontal disease accounts for 80–90% of intraoral cases.[2] The
mechanisms linking volatile sulfur compound (VSC) dynamics to periodontal destruction, and the therapeutic implications of
co-management, remain incompletely defined. Methods:
Five databases (PubMed, Scopus, Web of Science, EMBASE, Cochrane) were searched without date restriction through
March 2025 per PRISMA 2020. Risk of bias was assessed using NOS (observational) and RoB2 (RCTs); evidence certainty via
GRADE.
Keywords :
Halitosis; Oral Malodor; Periodontitis; Volatile Sulfur Compounds; Oral Microbiome; Porphyromonas Gingivalis; Scaling and Root Planing; Meta-Analysis.
References :
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- Memon MA, Memon HA, Muhammad FE, Fahad S, Siddiqui A, Lee KY, et al. Aetiology and associations of halitosis: a systematic review. Oral Dis. 2023;29(4):1432-8. doi:10.1111/odi.14172
- Silva MF, Leite FRM, Ferreira LB, Pola NM, Scannapieco FA, Demarco FF, et al. Estimated prevalence of halitosis: a systematic review and meta-regression analysis. Clin Oral Investig. 2018;22(1):47-55. doi:10.1007/s00784-017-2164-5
- Nini W, Chen L, Jinmei Z, Lufei W, Jingmei Y. The association between halitosis and periodontitis: a systematic review and meta-analysis. Clin Oral Investig. 2024;28(6):341. doi:10.1007/s00784-024-05749-5
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- Tastan Eroglu Z, Kalender ME, Ucan Yarkac F, Babayigit O, Ozkan Sen D. Impact of non-surgical periodontal therapy on self-perceived halitosis, and the senses of smell and taste: a prospective clinical study. BMC Oral Health. 2025;25(1):321. doi:10.1186/s12903-025-05702-2
- Passadakis GP, Neophytou C, Davidopoulou S, Papadimitriou K. Effectiveness of probiotics in managing oral halitosis: a systematic review of randomized controlled trials. J Int Soc Prevent Communit Dent. 2025;15(4):301-12. doi:10.4103/jispcd.jispcd_19_25
- Lee CH, Kho HS, Chung SC, Lee SW, Kim YK. The relationship between volatile sulfur compounds and major halitosis-inducing factors. J Periodontol. 2003;74(1):32-7. doi:10.1902/jop.2003.74.1.32
- Quirynen M, Dadamio J, Van den Velde S, De Smit M, Dekeyser C, Van Tornout M, et al. Characteristics of 2000 patients who visited a halitosis clinic. J Clin Periodontol. 2009;36(11):970-5. doi:10.1111/j.1600-051X.2009.01478.x
- Suzuki N, Yoneda M, Hirofuji T. Mixed red-complex bacterial infection in periodontitis. Int J Dent. 2013;2013:587279. doi:10.1155/2013/587279
- Fu H, Li X, Zhang R, Yan Y, Sun C, Guo T, et al. Global burden of periodontal diseases among the working-age population from 1990-2021. BMC Public Health. 2025;25:1316. doi:10.1186/s12889-025-22566-x
- GBD 2021 Oral Disorders Collaborators. Trends in the global, regional, and national burden of oral conditions from 1990 to 2021. Lancet. 2025;405(10482):897-910. doi:10.1016/S0140-6736(25)00017-0
- Nascimento GG, Alves-Costa S, Romandini M. Burden of severe periodontitis and edentulism in 2021, with projections up to 2050. BMC Oral Health. 2025;25:861. doi:10.1186/s12903-025-06271-0
- Hampelska K, Jaworska MM, Babalska ZL, Karpinski TM. The role of oral microbiota in intra-oral halitosis. J Clin Med. 2020;9(8):2484. doi:10.3390/jcm9082484
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- Stando-Retecka M, Piatek P, Namiecinska M, Bonikowski R, Lewkowicz P, Lewkowicz N. Clinical and microbiological outcomes of subgingival instrumentation supplemented with high-dose omega-3 PUFA. BMC Oral Health. 2023;23(1):290. doi:10.1186/s12903-023-02992-w
- Mei H, Qi C, Liu J, Yang S, Zhou J, Lu Y, et al. hTAS2R38 polymorphisms modulate oral microbiota and influence the prevalence and treatment outcome of halitosis. Microbiome. 2025;13(1):85. doi:10.1186/s40168-025-02087-w
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Background
Halitosis affects 31.8% of adults globally[3] and periodontal disease accounts for 80–90% of intraoral cases.[2] The
mechanisms linking volatile sulfur compound (VSC) dynamics to periodontal destruction, and the therapeutic implications of
co-management, remain incompletely defined. Methods:
Five databases (PubMed, Scopus, Web of Science, EMBASE, Cochrane) were searched without date restriction through
March 2025 per PRISMA 2020. Risk of bias was assessed using NOS (observational) and RoB2 (RCTs); evidence certainty via
GRADE.
Keywords :
Halitosis; Oral Malodor; Periodontitis; Volatile Sulfur Compounds; Oral Microbiome; Porphyromonas Gingivalis; Scaling and Root Planing; Meta-Analysis.