Authors :
Garvit Singh; Pankaj Vyas
Volume/Issue :
Volume 9 - 2024, Issue 10 - October
Google Scholar :
https://tinyurl.com/3rxvjhs3
Scribd :
https://tinyurl.com/4btmss6t
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24OCT870
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
The onset of the antibiotics period was
characterised by the clinical implementation of
penicillin, the inaugural antibiotic, unearthed in 1928 by
Alexander Fleming in the green mould Penicillium
notatum. Garlic and clove have long been used as
traditional treatments for different diseases, including
infections. Their antibacterial qualities have been
attributed to their sulfur-containing components, such as
allicin and ajoene in garlic, and eugenol and isoeugenol
in clove. In this study, we wanted to produce a novel
antibacterial cream leveraging the synergistic properties
of garlic and clove extracts. The cream was
manufactured utilizing a simple and scalable technique,
and its antimicrobial activity was assessed against a
panel of microbes present in our surrounding. The
results indicated that the cream had considerable
antibacterial action against all tested microorganisms,
with minimum inhibitory concentrations (MICs)
comparable to conventional antibiotics. This study
establishes a groundbreaking, ecologically-oriented
method for safeguarding and healing the skin. The
tropical antimicrobial cream provides a secure and
efficient substitute for traditional antimicrobials that
may have harsh effects, while also including the
nourishing and rejuvenating qualities of tropical
botanicals. This groundbreaking research marks a
significant advancement in the realm of natural, holistic
skin health solutions. The tropical antimicrobial cream
stands as a potent alternative to conventional, potentially
harsh antimicrobials, offering a safe and effective way to
combat skin infections and irritations. Furthermore, its
incorporation of nourishing and restorative tropical
botanicals transcends mere protection, promoting
overall skin health and well-being. Beyond the individual
benefits, this innovation holds immense potential for
promoting sustainable practices within tropical
ecosystems by leveraging resources responsibly and
ethically. This paves the way for a future where nature's
wisdom empowers us to safeguard our skin with gentle
effectiveness, while simultaneously cherishing and
preserving the biodiversity that holds the key to our
well-being.
Keywords :
Garlic, clove Extracts, Antimicrobial, Natural Ingredients, Skin Cream, Anti-Inflammatory, Wound Healing.
References :
- Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microbes Infect. 1999;1(2):125-129. doi:10.1016/s1286-4579(99)80003-3
- Naganawa R, Iwata N, Ishikawa K, Fukuda H, Fujino T, Suzuki A. Inhibition of microbial growth by ajoene, a sulfur-containing compound derived from garlic. Appl Environ Microbiol. 1996;62(11):4238-4242. doi:10.1128/aem.62.11.4238-4242.1996
- Hayashi, Mirian A et al. “Antimicrobial compounds from natural sources.” Frontiers in microbiology vol. 4 195. 15 Jul. 2013, doi:10.3389/fmicb.2013.00195
- Pramod K, Ansari SH, Ali J. Eugenol: A Natural Compound with Versatile Pharmacological Actions. Natural Product Communications. 2010;5(12). doi:10.1177/1934578X1000501236
- Bhatwalkar SB, Mondal R, Krishna SBN, Adam JK, Govender P, Anupam R. Antibacterial Properties of Organosulfur Compounds of Garlic (Allium sativum). Front Microbiol. 2021 Jul 27;12:613077. doi: 10.3389/fmicb.2021.613077. PMID: 34394014; PMCID: PMC8362743.
- Song, Fuhang. “Antimicrobial Natural Products.” Antibiotics (Basel, Switzerland) vol. 11,12 1765. 7 Dec. 2022, doi:10.3390/antibiotics11121765
- Wang Y, Khan FA, Siddiqui M, et al. The genus Schefflera: A review of traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 2021;279:113675. doi:10.1016/j.jep.2020.113675
- Tsao SM, Yin MC. In-vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oils. J Med Microbiol. 2001;50(7):646-649. doi:10.1099/0022-1317-50-7-646
- Yang, Xin & Bai, Shuang & Wu, Jiamin & Fan, Yunlong & Zou, Yuekun & Xia, Zhikuan & Ao, Junhong & Chen, Tong & Zhang, Mingwang & Yang, Rongya. (2023). Antifungal Activity and Potential Action Mechanism of Allicin against Trichosporon asahii. Microbiology spectrum. 11. e0090723. 10.1128/spectrum.00907-23.
- Borlinghaus, Jan & Foerster, Jana & Kappler, Ulrike & Antelmann, Haike & Noll, Ulrike & Gruhlke, Martin & Slusarenko, Alan. (2021). Allicin, the Odor of Freshly Crushed Garlic: A Review of Recent Progress in Understanding Allicin’s Effects on Cells. Molecules. 26. 1505. 10.3390/molecules26061505.
- Yadav MK, Chae SW, Im GJ, Chung JW, Song JJ. Eugenol: a phyto-compound effective against methicillin-resistant and methicillin-sensitive Staphylococcus aureus clinical strain biofilms. PLoS One. 2015 Mar 17;10(3):e0119564. doi: 10.1371/journal.pone.0119564. PMID: 25781975; PMCID: PMC4364371.
- Chopra I, Hesse L, O'Neill AJ. Exploiting current understanding of antibiotic action for discovery of new drugs. J Appl Microbiol. 2002;92 Suppl:4S-15S.
- Wüllner, Dominik & Haupt, Annika & Dietze, Pascal & Leontiev, Roman & Slusarenko, Alan & Bandow, Julia. (2019). Interspecies Comparison of the Bacterial Response to Allicin Reveals Species‐Specific Defense Strategies. PROTEOMICS. 19. 1900064. 10.1002/pmic.201900064.
- Pimpale, Amol. (2018). Formulation and Evaluation of Antibacterial, Antifungal Cream of Garlic Oil. International Journal of Trend in Scientific Research and Development. Volume-3. 849-852. 10.31142/ijtsrd19046.
- Bhinge SD, Bhutkar MA, Randive DS, et al. Formulation development and evaluation of antimicrobial polyherbal gel. Ann Pharm Fr. 2017;75(5):349-358. doi:10.1016/j.pharma.2017.04.006
- NEJAD, Solmaz & Özgüneş, Hilal & BAŞARAN, Nurşen. (2017). Pharmacological and Toxicological Properties of Eugenol. The Turkish Journal of Pharmaceutical Sciences. 14. 201-206. 10.4274/tjps.62207.
- Dhwani, S & Pushparaj, Poojitha & Pa, Parameswaran. (2021). A REVIEW ON DIFFERENT EXTRACTION AND QUANTIFICATION METHODS OF ALLICIN FROM GARLIC. 10.37896/jxu15.6/020.
- S. Bom, J. Jorge, H.M. Ribeiro, J. Marto, A step forward on sustainability in the cosmetics industry: A review, Journal of Cleaner Production
- Extraction of Allicin (scienceteacherprogram.org)
- Harnessing Nature's Bounty: Exploring the Uses and Health Benefits of Garlic - Goodmealtime
- Amazon.com: Herbal Roots Organic Whole Bulb Garlic Pills - Potent Extra Strength | 600 mg - 60 Organic Vegan Capsules : Health & Household
The onset of the antibiotics period was
characterised by the clinical implementation of
penicillin, the inaugural antibiotic, unearthed in 1928 by
Alexander Fleming in the green mould Penicillium
notatum. Garlic and clove have long been used as
traditional treatments for different diseases, including
infections. Their antibacterial qualities have been
attributed to their sulfur-containing components, such as
allicin and ajoene in garlic, and eugenol and isoeugenol
in clove. In this study, we wanted to produce a novel
antibacterial cream leveraging the synergistic properties
of garlic and clove extracts. The cream was
manufactured utilizing a simple and scalable technique,
and its antimicrobial activity was assessed against a
panel of microbes present in our surrounding. The
results indicated that the cream had considerable
antibacterial action against all tested microorganisms,
with minimum inhibitory concentrations (MICs)
comparable to conventional antibiotics. This study
establishes a groundbreaking, ecologically-oriented
method for safeguarding and healing the skin. The
tropical antimicrobial cream provides a secure and
efficient substitute for traditional antimicrobials that
may have harsh effects, while also including the
nourishing and rejuvenating qualities of tropical
botanicals. This groundbreaking research marks a
significant advancement in the realm of natural, holistic
skin health solutions. The tropical antimicrobial cream
stands as a potent alternative to conventional, potentially
harsh antimicrobials, offering a safe and effective way to
combat skin infections and irritations. Furthermore, its
incorporation of nourishing and restorative tropical
botanicals transcends mere protection, promoting
overall skin health and well-being. Beyond the individual
benefits, this innovation holds immense potential for
promoting sustainable practices within tropical
ecosystems by leveraging resources responsibly and
ethically. This paves the way for a future where nature's
wisdom empowers us to safeguard our skin with gentle
effectiveness, while simultaneously cherishing and
preserving the biodiversity that holds the key to our
well-being.
Keywords :
Garlic, clove Extracts, Antimicrobial, Natural Ingredients, Skin Cream, Anti-Inflammatory, Wound Healing.