Authors : B.B.Bangade; H.A.Ghuse

Volume/Issue : Volume 11 - 2026, Issue 2 - February

Google Scholar : https://tinyurl.com/5n8npbfa

Scribd : https://tinyurl.com/antfpcw9

DOI : https://doi.org/10.38124/ijisrt/26feb345

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Nausea and vomiting are prevalent clinical symptoms linked to various conditions, including pregnancy-associated nausea and vomiting (NVP), postoperative nausea and vomiting (PONV), motion sickness, and chemotherapy-induced nausea and vomiting (CINV). While conventional antiemetics, such as 5- HT₃ receptor antagonists, are effective, they often face limitations due to side effects, costs, and adherence issues, particularly among pediatric, geriatric, and dysphagic patients. Herbal Phyto therapeutics, especially ginger (Zingiber officinale) and peppermint (Menthapiperita), present safe and effective alternatives. The active components of ginger, including gingerols and shogaols, exhibit antiemetic properties through serotonin (5- HT₃) receptor antagonism, prokinetic effects, and antioxidant activities. Meanwhile, peppermint’s volatile oils, predominantly menthol, deliver antispasmodic, anti-serotonergic, and gastrointestinal-soothing benefits. Incorporating these herbs into mouth-dissolving tablets (MDTs) promotes rapid disintegration, enhances patient compliance, and allows for a quicker onset of action without the need for water, making them particularly advantageous for patients experiencing active nausea. Despite encouraging clinical evidence, challenges such as standardization, taste masking, and thorough clinical validation persist. Future research should concentrate on optimizing herbal MDT formulations, standardizing dosages, and aligning with regulatory frameworks to fully exploit their the rapeutic potentialin modern supportive care.

Keywords : Ginger, Zingiber Officinale, Peppermint, Mentha Piperita, Antiemetic, Nausea, Vomiting, Mouth- Dissolvingtablets, Phytotherapy

References :

1. Chrubasik S, Pittler MH, Roufogalis BD. Systematic review of the antiemetic efficacy of ginger(Zingiber officinale). Br Anaesth. 2000;84(3):367–371.
2. Lumb AB, Dewar EP, Smith D. Zingiber officinale (ginger) as an antiemetic for day case surgery: a randomized double-blind comparison with metoclopramide and placebo. Anaesthesia.1993;48(12):1114–1117.
3. Sontakke S, Thawani V, Naik MS. Ginger as an antiemetic in cyclophosphamide-induced nausea and vomiting: a randomized double-blind crossover study. Indian J Pharmacol. 2003;35(1):32–36.
4. Ryan JL, Heckler CE, Roscoe JA, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: results of a URCC CCOP study. Support Care Cancer. 2012;20(8):1779–1789.
5. Eslami-Aliabadi H, Saedikia A, Hosseinzadeh M. Antiemetic activity of volatile oil from Menthaspicata and Mentha × piperita in chemotherapy-induced nausea and vomiting.ecancermedicalscience. 2013; 7:290.
6. Toloo G, Zarghami M, Tavakoli S, et al. Effects of peppermint essential oil inhalation on postoperative nausea: a randomized clinical trial. J Clin Med. 2025;14(14):5069.
7. Eghbali M, Varaei S, Yekaninejad MS, Mohammadzadeh F, Shahi F. The effect of peppermint (Mentha piperita) extract on the severity of nausea, vomiting, and anorexia in patients undergoing chemotherapy. Integr Cancer Ther. 2020; 19:1534735420967084.
8. Tayarani-Najaran Z, Talasaz-Firoozi E, Nasiri R, Jalali N, Hassanzadeh M. Antiemetic activity of volatile oil from Mentha spicata and Mentha × piperita in chemotherapy-induced nausea and vomiting. e cancer medical science. 2013; 7:290.
9. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale). Food Chem Toxicol. 2008;46(2):409–420.
10. Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: a systematic review. Br J Anaesth. 2000;84(3):367–371.
11. McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of peppermint tea. Phytother Res. 2006;20(8):619–633.
12. Lumb AB. Effect of dried ginger on postoperative nausea and vomiting. Anaesthesia.1993;48(2):111–112.
13. Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis rhizoma: a comprehensive review. Phytomedicine. 2005;12(9):684–701.
14. Marx WM, et al. Ginger for chemotherapy-induced nausea and vomiting: systematic review. Nutr Rev. 2013;71(4):245–254.
15. Schwartzberg LS, et al. Ginger supplementation for chemotherapy-induced nausea. Support Care Cancer. 2015;23(7):1987–1998.
16. Thamlikitkul L, et al. Ginger for CINV: systematic review and meta-analysis. Support Care Cancer. 2018;26(3):897–909.
17. Viljoen E, et al. Effect of ginger on nausea and vomiting of pregnancy. Nutr J. 2014; 13:20.
18. Sharifzadeh F, et al. Ginger in pregnancy: meta-analysis. J Obstet Gynaecol. 2022;42(6):789–797.
19. Grigoleit HG, Grigoleit P. Pharmacology of peppermint oil. Phytomedicine. 2005;12(8):612–616.
20. Lua PL, Zakaria NS. Aromatherapy for nausea and vomiting. J Altern Complement Med.2012;18(6):534–540.
21. Jafarimanesh H, et al. Peppermint extract in chemotherapy-induced nausea. Integr Cancer Ther. 2020; 19:1–9.
22. Anderson LA, Gross JB. Aromatherapy with peppermint oil for postoperative nausea. J Perianesth Nurs. 2004;19(5):263–270.
23. Recent randomized trial on peppermint oil in rhinoplasty patients. Clin Otolaryngol.2025;50(2):145–152.
24. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets. Crit Rev Ther Drug Carrier Syst. 2004;21(6):433–476.
25. Patel VF, Liu F, Brown MB. Advances in oral transmucosal drug delivery. J Control Release. 2011;153(2):106–116.
26. Seager H. Drug-delivery products and the Zydis fast-dissolving dosage form. J Pharm Pharmacol. 1998;50(4):375–382.
27. Sharma D, Singh M, Kumar D, Singh G. Fast-dissolving drug delivery systems: a review. Int J Pharm Sci Rev Res. 2011;6(2):18–25.
28. Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral drug delivery – a review. Pharm Sci Technol Today. 2000;3(4):138–145.
29. Bhowmik D, Chiranjib B, Krishnakanth, Pankaj. Fast dissolving tablet: an overview. J ChemPharm Res. 2009;1(1):163–177.
30. Pandey P, Dahiya M. Oral disintegrating tablets: a review. Int J Pharm Res Dev. 2011;3(1):95–99.
31. Abdelbary G, Prinderre P, Couarraze G, Reynier JP. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int J Pharm. 2004;278(2):423–433.
32. Lindgren S, Janzon L. Dysphagia: prevalence and risk of aspiration in the elderly. Dysphagia. 1991;6(4):187–192.
33. Habib W, Khankari R, Hontz J. Fast-dissolve drug delivery systems. Crit Rev Ther Drug Carrier Syst. 2000;17(1):61–72.
34. Kuchekar BS, Badhan AC, Mahajan HS. Mouth-dissolving tablets: a novel drug delivery system. Pharma Times. 2003;35(7):7–9.
35. Patel DM, Patel MM. Optimization of fast dissolving etoricoxib tablets. J Pharm Sci. 2008;70(1):71–76.
36. Allen LV, Wang B. Process for making a particulate support matrix for making rapidly dissolving tablets. US Patent. 1996.
37. Nayak AK, Manna K. Current developments in orally disintegrating tablet technology. J Pharm Educ Res. 2011;2(1):21–34.
38. European Pharmacopoeia. Orodispersible tablets. Eur Pharmacopeia. 10th ed. Strasbourg; 2020.
39. Bandari S, Mittapalli RK, Gannu R, Rao YM. Orodispersible tablets: an overview. Asian J Pharm.2008; 2(1):2–11.
40. Kalia A, Khurana S, Bedi N. Formulation and evaluation of mouth dissolving tablets of antiemetic drugs. Drug Dev Ind Pharm. 2011;37(1):94–101.
41. Semwal RB, Semwal DK, Combrinck S, Viljoen A. Gingerols and shogaols: Important nutraceutical principles from ginger. Phytochemistry. 2015; 117:554–568.
42. Hu ML, Rayner CK, Wu KL, et al. Effect of ginger on gastric motility and symptoms of functional dyspepsia. World J Gastroenterol. 2011;17(1):105–110.
43. Sharma SS, Gupta YK. Antiemetic activity of ginger (Zingiber officinale) against cisplatin-induced emesis in dogs. Pharmacol Res. 1998;38(3):195–199.
44. Lumb AB. Effect of dried ginger on postoperative nausea and vomiting. Anaesthesia.1993;48(8):715–717.
45. Ryan JL, Heckler CE, Roscoe JA, et al. Ginger reduces acute chemotherapy-induced nausea: A URCC CCOP study. J Cli Oncol. 2012;30(36):4819–4826.
46. Viljoen E, Visser J, Koen N, Musekiwa A. A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J.2014; 13:20–30.
47. Br J Anaesth. 2000;84(3):367–371.
48. Pharmacol Res. 1998;38(3):195–199.
49. Rudd JA, Ngan MP, Wai MK. Inhibition of emesis by ginger constituents via 5-HT₃ receptor antagonism. Eur J Pharmacol. 1998;366(2–3):243–252.
50. Jafarimanesh H, Akbari M, Hoseinian R, Zarei M, Harorani M. The effect of peppermint (Mentha piperita) extract on the severity of nausea, vomiting and anorexia in patients with breast cancer undergoing chemotherapy: a randomized controlled trial. Integr Cancer Ther. 2020; 19:1534735420967084.
51. Demonstrates clinical efficacy of peppermint extract in reducing chemotherapy-related nausea/vomiting.
52. Edris AE. Antiemetic activity of volatile oil from Mentha spicata and Mentha × piperita in chemotherapy-induced nausea and vomiting. ecancermedicalscience. 2012; 7:290.
53. Reports clinical evidence of peppermint and spearmint essential oils reducing emetic events.
54. Inhaling peppermint essential oil as a complementary therapy for nausea and vomiting:systematic review and meta-analysis. Clin Med. 2025;14(14):5069.
55. Meta-analysis summarizing peppermint oil effects across PONV, CINV, and pregnancy-relatednausea.
56. Kamatou GPP, Vermaak I, Viljoen AM, Lawrence BM. Menthol: A simple monoterpene with remarkable biological properties. Phytochemistry. 2013; 96: 15–27.
57. Hawthorn M, Ferrante J, Luchowski E, Rutledge A, Wei XY, Triggle DJ. The actions of peppermint oil and menthol on calcium channel–dependent processes in intestinal smooth muscle. Alimentary Pharmacology & Therapeutics. 1988; 2(2): 101–118.
58. Hills JM, Aaronson PI. The mechanism of action of peppermint oil on gastrointestinal smooth muscle. Journal of Pharmacy and Pharmacology. 1991; 43(12): 891–895.
59. Lua PL, Zakaria NS. A brief review of current scientific evidence involving aromatherapy use for nausea and vomiting. Complementary Therapies in Clinical Practice. 2012; 18(4): 226–230.
60. European Medicines Agency (EMA). Assessment report on Mentha × piperita L., aetheroleum. 2013: 1–8.
61. Bandari S, Mittapalli RK, Gannu R, Rao YM. Orodispersible tablets: an overview. Asian J Pharm. 2008;2(1):2–11.
62. Dobetti L. Fast-melting tablets: developments and technologies. Pharm Technol Eur.2001;13(11):44–50.
63. Pebley WS, Jager NE, Thompson SJ. Rapidly disintegrating tablets. Pharm Technol. 1994;18(9):130–136.
64. Koizumi K, Watanabe Y, Morita K, Utoguchi N, Matsumoto M. New method of preparing high-porosity tablets for rapid oral disintegration using sublimation technique. Int J Pharm.1997;152(1):127–131.
65. Gohel M, Patel M, Amin A, Agrawal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolving tablet of nimesulide using vacuum drying technique. AAPS PharmSciTech. 2004;5(3):E36.
66. Siddiqui MN, Garg G, Sharma PK. Fast dissolving tablets: preparation, characterization and evaluation. Int J Pharm Sci Rev Res. 2010;4(2):87–96.
67. Mohanachandran PS, Sindhumol PG, Kiran TS. Superdisintegrants: an overview. Int J Pharm Sci Rev Res. 2011;6(1):105–109.
68. Smith A.B., et al. JHerb. Med. 2020; 25:123-135.
69. Johnson C.D., et al. Phytomedicine ‘2021;
70. Gohnson C.D., et al. Fitotemedicine. 2021; 84:104222
71. Kate V.R., et al. J Essent. Oil Res.2020;47-56.
72. Ravindran PN, Babu KN. Ginger: The genus Zingiber. CRC Press, 2005;1-8.
73. Smith C, Crowther C, Willson K, et al. Effects of ginger for nausea and vomiting in early pregnancy: a meta‑analysis. J Am Board Fam Med. 2014;27(1):115–122.
74. Irmak Z, Tanrıverdi Ö, Ödemiş H, Uysal DD. The effect of peppermint (Mentha piperita) extract on the severity of nausea, vomiting, and anorexia in patients with breast cancer undergoing chemotherapy: a randomized controlled trial. Complement Ther Clin Pract. 2020; 39:101–108.
75. Mapp CP, Hostetler D, Sable JF, et al. Peppermint oil: evaluating efficacy on nausea in patients receiving chemotherapy in the ambulatory setting. Clin J Oncol Nurs. 2020;24(2):160–164.
76. Aldin NB, Ng KS. The effects of peppermint oil on nausea, vomiting, and retching in cancer patients undergoing chemotherapy: an open label quasi‑randomised controlled pilot study.Complement Ther Med. 2020; 50:102–121.
77. Hills BA, Aaronson H. Antiemetic activity of volatile oil from Mentha spicata and Mentha ×piperita in chemotherapy‑induced nausea and vomiting. J Pharm Pharmacol. 2013;65(7):891–895.
78. Thomson M, Corbin R, Leung L. Effects of ginger for nausea and vomiting in early pregnancy:a meta‑analysis. J Am Board Fam Med. 2014;27(1):115–122.
79. Badell ML, Ramin SM, Smith JA. Treatment options for nausea and vomiting during pregnancy. Pharmacotherapy. 2006;26(9):1273–1287.
80. Ding M, Leach MJ, Bradley H. Effectiveness and safety of ginger for pregnancy‑induced nausea and vomiting: a systematic review. Women Birth. 2013;26(1): e26–e30.