Authors : M. Saravana Kumar; D. Dhachinamoorthi; B. Premkumar; Afeefa Sherin; Shana; Murshid; Mohammed Irfan; Souraj

Volume/Issue : Volume 11 - 2026, Issue 3 - March

Google Scholar : https://tinyurl.com/56wrrjtw

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DOI : https://doi.org/10.38124/ijisrt/26mar2076

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Piper longum Linn. has garnered significant attention in recent years due to its diverse applications in both traditional and modern medicine. The plant's active compounds have been shown to exhibit anti-inflammatory, antioxidant, and antimicrobial properties, making it a valuable resource in the development of new therapeutic agents. Research indicates that the alkaloids present in Piper longum, such as piperine, play a crucial role in enhancing bioavailability and efficacy of various drugs, thereby supporting its use in combination therapies. Furthermore, ongoing studies are exploring the potential of Piper longum in managing chronic diseases, including diabetes and cardiovascular disorders. Its adaptogenic properties may also contribute to stress relief and improved overall well-being. As interest in natural remedies continues to rise, Piper longum stands out as a promising candidate for further exploration in pharmacological research, with the potential to bridge the gap between traditional knowledge and contemporary scientific validation. In conclusion, the multifaceted uses of Piper longum highlight its importance not only as a culinary spice but also as a significant player in the realm of health and wellness. Continued research will undoubtedly unveil more of its secrets, paving the way for innovative applications in medicine and beyond. Novel drug delivery technology refers to the approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body to safely achieve its desired therapeutic effects. Natural polymers are widely used in microspheres due to their biocompatibility, biodegradability, and ability to encapsulate drugs for sustained release. Starch Microspheres advantages are Abundant, low cost, and easily modifiable. Cellulose Microspheres' advantages are High stability and versatility in formulation. Dextran Microspheres advantages are low immunogenicity and tunable degradation. Natural polymers are increasingly vital in pharmaceutical formulations for targeted drug delivery and sustained/controlled-release microspheres, particularly for herbal drug formulations. Their biocompatibility, biodegradability, and ability to encapsulate bioactive herbal compounds make them ideal for delivering plant-derived drugs with improved efficacy and safety.

Keywords : Natural Polymers, Microspheres Technology, Piper Longum Linn., Novel Drug Delivery Technology; Pharmacological and Therapeutic Activities.

References :

1. Sivarajan, V. V., & Balachandran, I. (1994). *Ayurvedic drugs and their plant sources*. Oxford and IBH Publishing.
2. Subramaniam, K., Subramanian, S. K., Bhargav, S., Parameswari, R., Praveena, R., Ravikumar, R., Yuvaraj, E., & Kumar, V. M. (2021). Review on potential antiviral and immunomodulatory properties of Piper Longum. *IOP Conference Series: Materials Science and Engineering*, *1145*(1), 012099. IOP Publishing.
3. Mehta, A., Zitzmann, N., Rudd, P. M., Block, T. M., & Dwek, R. A. (1998). α-Glucosidase inhibitors as potential broad-based anti-viral agents. *FEBS letters*, *430*(1-2), 17-22.
4. Wakade, A. S., Shah, A. S., Kulkarni, M. P., & Juvekar, A. R. (2008). Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats. *46*, 528-533.
5. Dahanukar, S. A., Karandikar, S. M., & Desai, M. (1984). Efficacy of Piper longum in childhood asthma. *Indian Drugs*, *21*(9), 384-388.
6. Ratner, L., Vander Heyden, N., & Dedera, D. (1991). Inhibition of HIV and SIV infectivity by blockade of α glucosidase activity. *Virology*, *181*(1), 180-92.
7. Grover, M. (2021). Piper Longum (Pippalimool): A Systematic Review on The Traditional and Pharmacological Properties of The Plant. *World Journal of Pharmaceutical and Medical Research*, *7*(8), 81-289.
8. Tharakan, S. T., & Madhavan, M. (2017). Therapeutic Potential of Piper Longum. *International Journal of Pharmacy and Biological Sciences*, *7*(3), 123-128.
9. Saraf, A., & Saraf, A. (2014). Phytochemical and Antimicrobial Studies of Medicinal Plant Piper longum L. *International Journal of Pharmacognosy and Phytochemical Research*, *6*(2), 213-222.
10. Basak, U. C., & Mohapatra, M. (2015). Comparative Appraisal of Piperine Content in Various Female Spikes of Piper longum L., A Ret Medicinal Plant of Odisha. *World Journal of Pharmaceutical Research*, *4*(11), 1048-1058.
11. Jyothi, V. A., & Jabeen, S. (2025). A Review on Piper Longum. *International Journal of Pharmacy and Biological Sciences*, *15*(2), 91-99.
12. Joshi, K., Shukla, V. J., Nishteswar, K., Goyale, M., Shingadiya, R., & Chaudhary, S. (2015). Physicochemical and HPTLC analysis of Pippalimula (Root of Piper longum L.). *4*(4), 82-85.
13. Vinay, S., Renuka, K., Palak, V., Harisha, C. R., & Prajapati, P. K. (2012). Pharmacognostical and Phytochemical Study of Piper Longum L. And Piper Retrofractum Vahl. *Journal of Pharmaceutical and Scientific Innovation*, *1*(1), 62-66.
14. Mhaske, D. B., Sreedharan, S., & Mahadik, K. R. (2018). Role of Piperine as an Effective Bioenhancer in Drug Absorptio. *Pharmaceutica Analytica Acta*, *9*(7), 1-4.
15. Duarte, A. B. S., Gomes, R. C., & Regina, V. V. (2023). The Antitumor Activity of Piplartine: A Review. *Pharmaceuticals*, *16*, 1246.
16. Kumar, S., Kamboj, J., Suman, S., & Sharma, S. (2011). Overview for Various Aspects of the Health Benefits of Piper longum L. Fruit. *J Acupunct Meridian Stud*, *4*(2), 134−140.
17. Venkatesan, J., Alam, M. S., Hong, E. J., Kimb, S. K., & Shim, M. S. (2016). Preparation of piperlongumine-loaded chitosan nanoparticles for safe and efficient cancer therapy. *The Royal Society of Chemistry*, *6*, 79307–79316.
18. Swati, N. (2023). A Comprehensive Review of Pharmaceutical Microspheres. *International Journal of Pharmacy and Industrial Research*, *13*(3), 179-186.
19. Lakshmi, K. M. R., Rao, G. V., Naseema, S., & Lavanya, E. (2023). Formulation and Evaluation of Microspheres - A Review. *International Journal of Pharmacy and Pharmaceutical Research*, *27*(4), 310-322.
20. Rajeswari, S., Prasanthi, T., Sudha, N., & Swain, R. P. (2017). Natural Polymers: A Recent Review. *World Journal of Pharmacy and Pharmaceutical Sciences*, *6*(8), 472-494.
21. Sahil, K., Akanksha, M., Premjeet, S., & Bilandi, A. (2011). Microsphere: A Review. *International Journal of Research in Pharmacy and Chemistry*, *1*(4), 1184-1198.
22. Chaudhary, V., & Patel, R. K. (2022). Preparation and Evaluation of Acacia nilotica Gum Microsphere Using Various Cross-Linking Agents. *International Journal of Novel Research and Development*, *7*(7), 1420-1431.
23. Gavali, N., & Kotme, R. (2022). Novel Herbal Drug Microsphere Types of Preparation Characterization and Application: A Review. *International Journal of Trend in Scientific Research and Development*, *6*(7), 817-821.
24. Choudhary, P., Yadav, S., & Asija, R. (2022). A review on natural polymer-based microsphere. *World Journal of Biology Pharmacy and Health Sciences*, *12*(03), 088–093.
25. Hamzah, A. S., & Hadi, N. J. (2025). Study the Behavior of Microspheres Obtained from Natural Polymer as Drug Carriers. *Annales de Chimie - Science des Matériaux*, *49*(1), 55-61.
26. Farooq, U., Malviya, R., & Sharma, P. K. (2014). Advancement in Microsphere Preparation Using Natural Polymers and Recent Patents. *Recent Patents on Drug Delivery & Formulation*, *8*(2), 111-125.
27. Jose, J., Raju, D., & Nayak, P. (2010). Microspheres - Novel Drug Delivery Carrier For Plant Extracts For Antibacterial Activity. *Journal of Pharma Research and Development*, *2*(8), 120-121.
28. Gurumurthy, P., Vijayalatha, S., Sumathy, A., Asokan, M., & Naseema, M. (2012). Hepatoprotective effect of aqueous extract of Piper longum and piperine when administered with antitubercular drugs. *The Bioscan*, *7*(4), 661-3.