Authors : Toluwase Solomon OLAWUYI; Grace Temitope AKINGBADE; Rukayat Adesewa FARINDE; Adedoyin Motunrayo ADELEKE

Volume/Issue : Volume 9 - 2024, Issue 5 - May

Google Scholar : https://tinyurl.com/ywzx3yms

Scribd : https://tinyurl.com/bdhr2tyr

DOI : https://doi.org/10.38124/ijisrt/IJISRT24MAY1137

Abstract : Heavy metal exposure has raised concerns about increasing female infertility. This research delved into the protective effects of composite teas against aluminum-induced ovarian toxicity in female Wistar rats. The increase in female infertility index due to heavy metal exposure has been reported to have steadily increased over the years. This study investigated the protective effects of composite teas on aluminum-induced ovarian toxicity in adult female wistar rat. Thirty (30) adult female wistar rats (180g - 220g) were divided into 6 groups (n = 5). Group A received feed pellets and distilled water; Group B received 150mg/kg AlCl3; Group C received 150mg/kg AlCl3 and 5ml/kg of Green tea; Group D received 150mg/kg AlCl3 and 5ml/kg of Moringa tea; Group E received 150mg/kg AlCl3 and 5ml/kg of Turmeric tea and Group F received 150mg/kg AlCl3 and 5ml/kg of Lipton black tea. Conversely, composite tea administration notably improved antioxidant levels, hormone profiles, and preserved ovarian structures. This suggests composite teas mitigate oxidative stress-induced negative changes, improving ovarian histology, hormones. Conclusively, Composite teas possess the therapeutic efficacies to significantly limit the degree of oxidative stress-induced negative changes resulting in improved outcome of histological, hormonal and biochemical parameters of the ovary.

Keywords : Aluminum, Composite teas, Herbal plant, Histology, Ovary.

References :

1. Yokel  RA, McNamara PJ. Aluminium toxicokinetics: an updated minireview, Pharmacol. Toxicol. 2001; 88: 159–67.
2. Hewitt CD, Savory J, Wills MR. Aspects of aluminium toxicity, Clin. Lab. Med. 1990; 10: 403–22.
3. Joint FAO, WHO. Expert Committee on Food Additives, Report of the Seventy-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives. Rome, 2011; 14 – 23.
4. Joint FAO, WHO. Codex Alimentarius Commission, Report of the Twenty-Ninth Session of the Joint FAO/WHO Codex Alimentarius Commission, Geneva, July 3 – 7, 2006, Rome: World Health Organization, Food and Agriculture Organization of the United Nations, 2006.
5. Yousef MI, Kamel KI, Ei-Demerdash FM. An in vitro study on reproductive toxicity of aluminum chloride on rabbit sperm: the protective role of some antioxidants, Toxicology, 2007; 239: 213–23.
6. Sun H, Hu C, Jia L, Zhu Y, Zhao H, Shao B, Wang N,  Zhang Z, Li Y. Effects of aluminum exposure on serum sex hormones and androgen receptor expression in male rats, Biol Trace Elem Res 2011; 8: 144-1050.
7. Ige SF, Akhigbe RE. The role of Allium cepa on aluminum-induced reproductive dysfunction in experimental male rat models, J. Hum. Reprod. Sci. 2012; 5: 5-200.
8. Chinoy NJ, Patel NT. Effects of sodium fluoride and aluminum chloride on ovary and uterus of mice and their reversal by some antidotes, Fluoride, 2001; 34: 9–20.
9. Fu Y, Jia FB, Wang J, Song M, Liu SM, Li YF, Liu SZ, Bu QW. Effect of sub-chronic aluminum chloride exposure on rat ovaries, Life Sci. 2014; 100 (1): 61-6.
10. Satsangi K, Jatav PC, Dua KK, Flora SJS. Preventive effects of a few dietary nutrients against acute aluminum toxicity in mice, Trace Elements in Medicine 2000; 17 (3): 134-137.
11. Hicks A. Current status and future development of global tea production and tea products, AU J. Technol. 2009; 12: 251–264.
12. Savolainen H. Tannin content of tea and coffee, J. Appl. Toxicol. 1992; 12: 191–192.
13. Zaveri NT. Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications, Life Sci. 2006; 78: 2073–2080.
14. Chen W, Sun S, Cao W, Liang Y, Song J. Antioxidant property of quercetin-Cr(III) complex: the role of Cr(III) ion, J. Mol. Struct. 2009; 918: 194–197.
15. Adelakun SA, Ukwenya VO, Ogunlade B, Aniah AJ, Ibiayo GA. Nitrite-induced testicular toxicity in rats: therapeutic potential of walnut oil, J. Braz. Soc. Assist. Reprod.2019; 23 (1): 15–23.
16. Varshney R, Kale RK. Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes. Int. J. Rad. Biol. 1990; 58: 733 – 743.
17. Rotruck J, Pope A, Ganther H, Swanson A. Selenium: Biochemical roles as a component of glutathione peroxidase, Science 1973; 179: 588–590.
18. Crosti N, Servidei T, Bajer J, Serra A.  Modification of the 6-hydroxydopamine technique for the correct determination of superoxide dismutase, J. Clin. Biochem. 1987; 25: 265–266.
19. Exley C. The pro-oxidant activity of aluminum, Free Radic. Biol. Med. 2004; 36: 380-387.
20. Buraimoh AA, Ojo SA. Effects of aluminium chloride exposure on the body weight of wistar rats, Annals of Biol. Sci. 2014; 2 (2): 66-77.
21. Golub MS, Germann SL. Long term consequences of developmental exposure to aluminum in a suboptimal diet for growth and behavior of Swiss Webster mice, Neurotoxicol. Teratol. 2001; 23: 365-372.
22. Kimura K, Hirako M, Iwata M. Aoki M, Kawaguchi M, Seki M. Successful superovulation of cattle by a single administration of FSH in aluminum hydroxide gel, Theriogenology  2009; 68 (4): 633-639.Z.
23. Mohammed A, Mayyas I, Elbetieha A, Shoter A, Khamas W, Elnasser  Z. Toxicity evaluation of aluminium chloride on adult female mice, J. Anim. Vet. Adv. 2008; 7: 552–556.
24. Chinoy NJ, Patel TN. Effect of sodium fluoride and aluminium chloride on ovary and uterus of mice and their reversal by some antidotes, Fluoride  2001; 34 (1): 9–20.
25. Wang N, She, Y, Zhu Y, Zhao H, Shao B, Sun H, Hu C, Li Y. Effects of sub chronic aluminum exposure on the reproductive function in female rats, Biological Trace Element Research, 2011 145 (3): 382-7.
26. Sargazi M, Shenkin A, Roberts NB. Aluminium-induced injury to kidney proximal tubular cells: Effects on markers of oxidative damage, J. Trace Elem. Med. Biol. 2006; 19: 267-273.
27. R. Moumen, N. Ait-Oukhatar, F. Bureau, C. Fleury, D. Bouglé, P. Arhan, Aluminium increases xanthine oxidase activity and disturbs antioxidant status in the rat, J. Trace Elem. Med. Biol. 15 (2001) 89-93.
28. B. Nehru, P. Anand, Oxidative damage following chronic aluminium exposure in adult and pup rat brains, J. Trace Elem. Med. Biol. 19 (2005) 203-208.
29. 29 A. Winiarska-Mieczan, Protective effect of tea against lead and cadium-induced oxidative stress, Biometals 13 (2018) 909- 926.
30. A. Jelenkovic, J. Marina, S. Ivana, D.P. Natasa, R.B. Dubravko, Z. Jelena, R. Igic, Influence of the Green Tea Leaf Extract on Neurotoxicity of Aluminium chloride in rats, Phytother. Res. 28 (1) (2013) 1002-4962.
31. C. Ebrahim, R. Kambiz, The protective effect of curcumin against aluminum chloride-induced oxidative stress and hepatotoxicity in rats, Pharm. Biomed. Res. 5 (1) (2019) 11-18.