Histomorphology, Hormonal Changes and Redox Imbalance in Aluminum-Induced Testicular Toxicity: The Mitigating Influence of Ethanolic StembarkExtract of Prosopis africana.


Authors : Olawuyi T. S; Akinola B. K; Ukwenya V. O; Ayanda O. F

Volume/Issue : Volume 7 - 2022, Issue 2 - February

Google Scholar : http://bitly.ws/gu88

Scribd : https://bit.ly/3q8lwW8

DOI : https://doi.org/10.5281/zenodo.6360878

The study aimed at mitigating effect of ethanolic stembark extract of Prosopis africana on aluminum-induced testicular toxicity in adult Wistar rats. Twenty-five Wistar rats of an average weight of 200g were grouped into five: Normal control, AlCl3 (200 mg/kg/ d), 200mg/kg/d P. africana, AlCl3 (200 mg/kg/ d) + 200mg/kg/ d P. africana and AlCl3 (200 mg/kg/d) + 400mg/kg/d P. africana groups. All animals were fed orally and allowed access to water ad libitum for four weeks. Testicular histology, semen parameters, biochemical assays and testosterone hormone were assessed. The degenerative seminiferous tubule histoarchitecture due to AlCl3 toxicity was improved by Prosopis africana extract. Notably, the group with extract alone showed superlative values in all investigated parameters relative to the other groups. This study also showed the significant reduction in testicular mass and parameters. There was improvement in sperm parameters in group co-treated with Prosopis Africana extract groups. This study showed reduced antioxidant level of SOD and increased MDA levels in the AlCl3 group relative to the other groups. This study demonstrated the ability of ethanolic stembark-extract of Prosopis africana to mitigate aluminium-induced testicular toxicity on reproductive functions and the pro-spermatogenic properties of the compound in boosting andrological parameters.

Keywords : Asthenospermia, Semen parameters, Testicular histology, Testicular toxicities

CALL FOR PAPERS


Paper Submission Last Date
30 - June - 2022

Paper Review Notification
In 1-2 Days

Paper Publishing
In 2-3 Days

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe