Human saliva is incredibly a versatile organic fluid. Its collection is easy and non-invasive. The biomarkers present in the saliva prove themselves to be of diagnostic and prognostic importance for oral diseases like, periodontitis, oral lichen planus and oral leukoplakia. These biomarkers include growth factors, enzymes and interleukins. They also help in diagnosis of these diseases and for evaluation of risk of malignancy, monitoring of disease and the response to provided treatment. However, more research are required to discover biomarkers and verification of their diagnostic and prognostic role in context with oral diseases is needed. This article review a complete and thorough assessment of importance of saliva as a diagnostic device for the potential diagnosis of oral and systemic disease.

Keywords : Saliva, Salivary biomarkers, Systemic disease, Cytokines, Genes.