Authors :
Allae Eddine BOUCHAIB; Mamadou Alpha BALDE; Abdellah BABAHABIB; Moulay El Mehdi ELHASSANI; Jaouad KOUACH
Volume/Issue :
Volume 8 - 2023, Issue 1 - January
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3XjSNM1
DOI :
https://doi.org/10.5281/zenodo.7633006
Abstract :
Homocysteine (Hct) is a substance produced in
the metabolism of methionine that can be found in our
daily diet. The mutation of the methylenetetrahydrofolate
reductase gene, especially for women with low folate
intake. Hyperhomocysteinemia (HHct) can be due to
several factors, such as a lack of folic acid, a deficiency in
vitamins B6 and B12, hypothyroidism, medications,
genetic anomalies, aging, and renal dysfunction.
Increased homocysteine levels in peripheral blood can
lead to vascular diseases, coronary artery dysfunction,
atherosclerotic changes, and embolic diseases. As a result,
increased thrombogenicity in pregnant women upstream
of the trophoblast plug, leading to clot formation and
early or late abortion. Recent studies have reported that
hyperhomocysteinemia is associated with many
pregnancy complications, including abortive disease, preeclampsia, premature delivery, retroplacental hematoma,
fetal growth restriction, and gestational diabetes.
Therefore, to prevent thrombosis, treatment relies on
anticoagulants, sometimes combined with low-dose
aspirin, especially for its anticoagulant effect. In this
article, we report a case of a patient with a history of
abortive disease on hyperhomocysteinemia who had a
full-term pregnancy, while reminding the metabolism of
homocysteine, its impact on pregnancy, and the interest in
prescribing folic acid to avoid complications related to
hyperhomocysteinemia
Keywords :
Hyperhomocysteinemia, Pregnancy, Abortive Disease, Thrombophilia
Homocysteine (Hct) is a substance produced in
the metabolism of methionine that can be found in our
daily diet. The mutation of the methylenetetrahydrofolate
reductase gene, especially for women with low folate
intake. Hyperhomocysteinemia (HHct) can be due to
several factors, such as a lack of folic acid, a deficiency in
vitamins B6 and B12, hypothyroidism, medications,
genetic anomalies, aging, and renal dysfunction.
Increased homocysteine levels in peripheral blood can
lead to vascular diseases, coronary artery dysfunction,
atherosclerotic changes, and embolic diseases. As a result,
increased thrombogenicity in pregnant women upstream
of the trophoblast plug, leading to clot formation and
early or late abortion. Recent studies have reported that
hyperhomocysteinemia is associated with many
pregnancy complications, including abortive disease, preeclampsia, premature delivery, retroplacental hematoma,
fetal growth restriction, and gestational diabetes.
Therefore, to prevent thrombosis, treatment relies on
anticoagulants, sometimes combined with low-dose
aspirin, especially for its anticoagulant effect. In this
article, we report a case of a patient with a history of
abortive disease on hyperhomocysteinemia who had a
full-term pregnancy, while reminding the metabolism of
homocysteine, its impact on pregnancy, and the interest in
prescribing folic acid to avoid complications related to
hyperhomocysteinemia
Keywords :
Hyperhomocysteinemia, Pregnancy, Abortive Disease, Thrombophilia