This experiment evaluatedthe hypoglycemic effect of methanol extract of Carica papaya leaves in alloxan-induced diabetic rats. Forty (40) male albino rats were grouped into eight: Group A (normal control), Group B (positive control) were induced and treated with glibenclamide, group C (negative control) were induced and not treated, group Dwas induced and treated with Carica papaya leave extract at doses of 200, group E induced and treated with Carica papaya leave extract at doses of 400, group F induced and treated with Carica papaya leave extract at doses of 600, group G induced and treated with Carica papaya leave extract at doses of 800 and group G induced and treated with Carica papayaleave extract at doses of 1000 mg/kg body weight. The blood glucose levels were determined before and after alloxan induction for 28 days. At the end of the experiment, the animals were sacrificed through ocular puncture for the biochemical parameters activity was compared with a reference standard of Acetylcholine esterase, trypsin and pepsin (2mg/kg) negative control of physiological saline. Alloxan-induced diabetic rats treated with methanol extract showed relatively no significant (p<0.05) difference in acetylcholine esterase, pepsin and trypsin concentration compared with the controls. The study suggests that alloxan-induced diabetic rats treated with Carica papayaleaves extract possess a hypoglycemic effect,contributing to its antioxidant property.

Keywords : Diabetes,Carica papaya leaves, physiological saline, acetylcholine esterase, diabetic rats.