Authors :
HACHLAF Mariem; ABDI Chaimae; NADIR Wydad; LKHOYAALI Sihame; ESSABER Hatim; LATIB Rachida; MRABTI Hind; EL GHISSASSI Brahim; BOUTAYEB Saber; ERRIHANI Hassan
Volume/Issue :
Volume 9 - 2024, Issue 6 - June
Google Scholar :
https://tinyurl.com/ytf7vcnt
Scribd :
https://tinyurl.com/rh9k6f2x
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24JUN891
Abstract :
Background:
Paclitaxel is a cytotoxic drug belonging to the taxane
family, widely used in medical oncology, such as in breast
cancer, in which it has demonstrated great efficacy,
whether as metastatic or adjuvant treatment. Paclitaxel's
main toxicities are immediate anaphylactic reactions and
peripheral neuropathy. The occurrence of idiopathic
intracranial hypertension is an unusual event.
The Clinical Case:
This is a 53-year-old Moroccan woman, treated for
breast cancer; she was put on sequential adjuvant
chemotherapy after surgery. She received 3 courses of
Doxorubicin and Cyclophosphamide without incident and
then we started weekly Paclitaxel. From the very first
courses, the patient presented with continuous but
moderate headaches, and a cerebral Magnetic Resonance
Imaging (MRI) showed signs of idiopathic intracranial
hypertension, which was confirmed and treated in the
neurology department. The patient progressed well,
allowing the 12 courses of paclitaxel to be continued.
Conclusion:
Idiopathic intracranial hypertension is an unusual
complication of paclitaxel. The occurrence of headache or
other neurological symptoms in a patient being treated for
breast cancer requires an urgent brain MRI, particularly
to look for brain metastases.
Keywords :
Breast Cancer, Idiopathic Intracranial Hypertension, Paclitaxel.
References :
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Background:
Paclitaxel is a cytotoxic drug belonging to the taxane
family, widely used in medical oncology, such as in breast
cancer, in which it has demonstrated great efficacy,
whether as metastatic or adjuvant treatment. Paclitaxel's
main toxicities are immediate anaphylactic reactions and
peripheral neuropathy. The occurrence of idiopathic
intracranial hypertension is an unusual event.
The Clinical Case:
This is a 53-year-old Moroccan woman, treated for
breast cancer; she was put on sequential adjuvant
chemotherapy after surgery. She received 3 courses of
Doxorubicin and Cyclophosphamide without incident and
then we started weekly Paclitaxel. From the very first
courses, the patient presented with continuous but
moderate headaches, and a cerebral Magnetic Resonance
Imaging (MRI) showed signs of idiopathic intracranial
hypertension, which was confirmed and treated in the
neurology department. The patient progressed well,
allowing the 12 courses of paclitaxel to be continued.
Conclusion:
Idiopathic intracranial hypertension is an unusual
complication of paclitaxel. The occurrence of headache or
other neurological symptoms in a patient being treated for
breast cancer requires an urgent brain MRI, particularly
to look for brain metastases.
Keywords :
Breast Cancer, Idiopathic Intracranial Hypertension, Paclitaxel.