Impact of Seminal Plasma Trace Elements Magnesium and Cadmium ' on Seminal Parameters among Infertile Sudanese Males in Khartoum State-Sudan


Authors : Amany Mudawy Albashir; Amira Siddig; Sara Abdel mahmoud

Volume/Issue : Volume 9 - 2024, Issue 12 - December

Google Scholar : https://tinyurl.com/ynumtm6c

Scribd : https://tinyurl.com/2s3yzkj4

DOI : https://doi.org/10.5281/zenodo.14576707

Abstract : Background: Male factors contribute for 40%–50% of cases of infertility, which affects 8%–12% of the world's population. Macro and trace components found in human seminal plasma are essential for the health and normal function of semen. Magnesium and cadmium levels in seminal plasma were measured as part of this study's attempt to connect these levels with male fertility.  Objectives: To determine the Impact of Seminal Plasma Trace Elements Magnesium and Cadmium ' on Seminal Parameters among Infertile Sudanese Males in Khartoum State-Sudan.  Methods: Between November 2021 and April 2022, all semen samples utilized in this comparative cross-sectional case- control study were collected from willing patients visiting Banoon and Ashmeeg Fertility Centres in Khartoum state. Males who had been diagnosed as infertile made up the study's case group (n = 150), while healthy males whose fertility had been established by prior successful fertility centers made up the study's control group (n = 150). The Buck model 210 VGP atomic absorption spectrophotometer was used to estimate the concentrations of TEs magnesium and cadmium. The SPSS version 23 was used for all analyses, in depended t testing was used to compare parameters between case and control and person correlation for correlate magnesium and cadmium with seminal analysis parameter . A P-value of 0.05 or lower was deemed statistically significant.  Results: Seminal cadmium levels were significantly greater and magnesium levels were lower in infertile men (p. value 0.000). Magnesium was found to have a strong negative association with semen volume (r=-.266 with p=0.008) and a substantial positive correlation with sperm count and motility (r=.994 and.216 with p=0.01 and 0.03). However, there was a negative connection between morphology and cadmium (r=-.362; p = 0.10).  Conclusion: According to the current study's findings, we conclude that, infertile men have high cadmium and low magnesium. Low magnesium has a direct impact on sperm count, sperm motility, and semen volume Conversely, sperm morphology is directly impacted by elevated cadmium.

References :

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Background: Male factors contribute for 40%–50% of cases of infertility, which affects 8%–12% of the world's population. Macro and trace components found in human seminal plasma are essential for the health and normal function of semen. Magnesium and cadmium levels in seminal plasma were measured as part of this study's attempt to connect these levels with male fertility.  Objectives: To determine the Impact of Seminal Plasma Trace Elements Magnesium and Cadmium ' on Seminal Parameters among Infertile Sudanese Males in Khartoum State-Sudan.  Methods: Between November 2021 and April 2022, all semen samples utilized in this comparative cross-sectional case- control study were collected from willing patients visiting Banoon and Ashmeeg Fertility Centres in Khartoum state. Males who had been diagnosed as infertile made up the study's case group (n = 150), while healthy males whose fertility had been established by prior successful fertility centers made up the study's control group (n = 150). The Buck model 210 VGP atomic absorption spectrophotometer was used to estimate the concentrations of TEs magnesium and cadmium. The SPSS version 23 was used for all analyses, in depended t testing was used to compare parameters between case and control and person correlation for correlate magnesium and cadmium with seminal analysis parameter . A P-value of 0.05 or lower was deemed statistically significant.  Results: Seminal cadmium levels were significantly greater and magnesium levels were lower in infertile men (p. value 0.000). Magnesium was found to have a strong negative association with semen volume (r=-.266 with p=0.008) and a substantial positive correlation with sperm count and motility (r=.994 and.216 with p=0.01 and 0.03). However, there was a negative connection between morphology and cadmium (r=-.362; p = 0.10).  Conclusion: According to the current study's findings, we conclude that, infertile men have high cadmium and low magnesium. Low magnesium has a direct impact on sperm count, sperm motility, and semen volume Conversely, sperm morphology is directly impacted by elevated cadmium.

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