Authors : Dhivya S.; Eswaramoorthy V.

Volume/Issue : Volume 11 - 2026, Issue 4 - April

Google Scholar : https://tinyurl.com/bdh5tb6t

Scribd : https://tinyurl.com/3buruhu2

DOI : https://doi.org/10.38124/ijisrt/26apr1481

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Abstract : Colorectal cancer (CRC) is still one of the main causes of cancer-related death globally, new therapeutic agents with increased effectiveness and fewer side effects must be investigated. The in-silico assessment of bioactive substances produced from Camptothecaacuminata in comparison with standard chemotherapeutic drugs for CRC treatment. Initially, bioactive compounds were identified from literature sources and screened based on drug-likeness and pharmacokinetic properties using ADME criteria. Potential protein targets associated with CRC were retrieved from relevant biological databases, and overlapping targets were identified to determine key therapeutic interactions. The binding affinity of particular drugs was evaluated using molecular docking research against critical CRC-associated proteins, followed by network pharmacology analysis to elucidate the underlying molecular mechanisms and pathways. The results demonstrated that several Camptotheca acuminata compounds exhibited significant binding affinity and comparable or superior interaction profiles relative to conventional chemotherapy drugs. Overall, this study highlights the promising role of natural compounds as alternative or complementary agents in CRC treatment and provides a computational foundation for further experimental validation and drug development.

Keywords : Colorectal Cancer; Camptotheca Accuminata; Network Pharmacology; Toxicity Analysis; Phytocompounds.

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