Authors : Yasotha S.; Manivannan R.; Kamalakannan Dhanabalan; Mathiyazhagan M.; Santhosh M.; Selva Suriya S.; Thenmozhi C.

Volume/Issue : Volume 11 - 2026, Issue 7 - July

Google Scholar : https://tinyurl.com/2bpktc2a

Scribd : https://tinyurl.com/3r9bzkpn

DOI : https://doi.org/10.38124/ijisrt/26jul1437

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : One of the leading causes of cancer-related mortality is now breast cancer, which is worldwide nowadays an unavoidable challenge of novel therapeutic strategies. This study aims to investigate the mechanism of molecular which approaches the anticancer potential of Wrightia tinctoria bark extract. Based on pharmacokinetic properties and physicochemical guidelines of the drug, active phytoconstituents were identified & screened. On identifying common targets, potential protein targets were predicted and linked up with breast cancer-associated genes. A protein-protein interaction (PPI) network & pathway analysis were determined using topological analysis. Functional enrichment & pathway analysis were performed to clarify biological relevance, and survival analysis was performed for clinical validation. A total of 239 phytochemical targets and 1595 disease-associated genes were identified by submitting 25 common targets. The key hub genes which are included are CCND1, CDK4, ESR1, MDM2, HIF1A & others. Enrichment analysis includes PI3K-Akt & JAK-STAT signalling. Survival analysis confirmed the predictive significance of CCND1 & CDK4. This information suggests that ‘Wrightia tinctoria’ has multi-target therapeutic potential & serves as the best source for breast cancer development.

Keywords : Breast Cancer; Wrightia tincoria bark; In-silico; Hub Genes.

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