Authors :
Rakshith H T; Rithesh Patel M D; Sanjay Gowda A V; S Lohita
Volume/Issue :
Volume 8 - 2023, Issue 11 - November
Google Scholar :
https://tinyurl.com/53ypdj62
Scribd :
https://tinyurl.com/3k77mxhu
DOI :
https://doi.org/10.5281/zenodo.10213053
Abstract :
Skin and soft tissue infections (SSTIs) are
widespread infections of the epidermis, dermis, or
subcutaneous tissue. Necrotizing soft tissue infections
(NSTIs) are uncommon and possibly deadly bacterial
infections that cause severe skin and subcutaneous tissue
necrosis. This review aims to figure out an overview of
Skin and soft tissue infection and management strategies
for NSTI. A literature review was performed to
determine the Antibiotics recommended for the empiric
treatment of NSTIs. As soon as NSTI is detected, empiric
therapy of broad-spectrum antibiotics should start. The
selection of the initial antibiotic is crucial. It has been
demonstrated that proper use of antibiotics is associated
with improved clinical outcomes and decreased morbidity
and death. Rapid surgical debridement of all
contaminated tissues, broad spectrum antibiotic therapy,
and intensive care unit treatment of related organ failures
are the cornerstone of the first urgent
management of NSTIs. As a result, clindamycin,
vancomycin, and piperacillin-tazobactam are frequently
used as the first treatment for NSTI. In comparison to
vancomycin, studies have found that linezolid is more
efficient in treating SSTIs caused by MRSA or Gram-
positive bacteria.
Keywords :
Skin and soft tissue infection, SSTI, Necrotizing soft tissue infection, NSTI, Rare bacterial infection.
Skin and soft tissue infections (SSTIs) are
widespread infections of the epidermis, dermis, or
subcutaneous tissue. Necrotizing soft tissue infections
(NSTIs) are uncommon and possibly deadly bacterial
infections that cause severe skin and subcutaneous tissue
necrosis. This review aims to figure out an overview of
Skin and soft tissue infection and management strategies
for NSTI. A literature review was performed to
determine the Antibiotics recommended for the empiric
treatment of NSTIs. As soon as NSTI is detected, empiric
therapy of broad-spectrum antibiotics should start. The
selection of the initial antibiotic is crucial. It has been
demonstrated that proper use of antibiotics is associated
with improved clinical outcomes and decreased morbidity
and death. Rapid surgical debridement of all
contaminated tissues, broad spectrum antibiotic therapy,
and intensive care unit treatment of related organ failures
are the cornerstone of the first urgent
management of NSTIs. As a result, clindamycin,
vancomycin, and piperacillin-tazobactam are frequently
used as the first treatment for NSTI. In comparison to
vancomycin, studies have found that linezolid is more
efficient in treating SSTIs caused by MRSA or Gram-
positive bacteria.
Keywords :
Skin and soft tissue infection, SSTI, Necrotizing soft tissue infection, NSTI, Rare bacterial infection.
