Authors : Hauwa S. Muhammad; Helmina O. Akanya; Egwin C. Evans; Emmanuel C. Onuekwusi

Volume/Issue : Volume 11 - 2026, Issue 1 - January

Google Scholar : https://tinyurl.com/4kv7fmjv

Scribd : https://tinyurl.com/ym3henz2

DOI : https://doi.org/10.38124/ijisrt/26jan1249

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Inflammation is a biological reaction of tissues to dangerous stimuli, such as pathogens, injury, and chemical irritants, which are necessary for healing, it may become pathological and lead to the development of chronic diseases. It entails an action of a collaborative response of immune cells, blood vessels and biochemical mediators meant to defend the host and restore tissue homeostasis. Synthetic drugs have many side effects that are associated with therapies and lead to the need to seek more natural therapies. The current review presents the information about the biochemical processes of inflammation, the classification of this phenomenon into acute and chronic inflammation, its clinical presentation, implication, causes, and the conventional and non-conventional methods of its treatment. The combination of conventional knowledge and the current scientific validation results in perspectives of creating effective, safe and accessible anti- inflammatory remedies. These processes are important to understand and to develop specific therapies to reduce the inflammatory diseases at the lowest cost.

Keywords : Inflammation, Acute Inflammation, Chronic Inflammation, Biochemical Mediators, Immune Response, Therapeutic Targets.

References :

1. Y. Geng, Z. Wang, J. Zhou, M. Zhu, J. Liu, and T. D. James, "Recent progress in the development of fluorescent probes for imaging pathological oxidative stress," Chemical Society Reviews, vol. 52, no. 11, pp. 3873-3926, 2023.
2. G. Harvanová and S. Duranková, "Inflammatory process: Factors inducing inflammation, forms and manifestations of inflammation, immunological significance of the inflammatory reaction," Alergologia Polska-Polish Journal of Allergology, vol. 12, no. 1, pp. 54-61, 2025.
3. M. Lekander, The Inflamed Feeling: The Brain's Role in Immune Defence, Oxford University Press, 2022.
4. M. E. Kim and J. S. Lee, "Molecular foundations of inflammatory diseases: insights into inflammation and inflammasomes," Current Issues in Molecular Biology, vol. 46, no. 1, pp. 469-484, 2024.
5. S. Akhter et al., "Role of Th17 and IL-17 cytokines on inflammatory and auto-immune diseases," Current Pharmaceutical Design, vol. 29, no. 26, pp. 2078-2090, 2023.
6. M. A. Chowdhury, N. Hossain, M. A. Kashem, M. A. Shahid, and A. Alam, "Immune response in COVID-19: A review," Journal of Infection and Public Health, vol. 13, no. 11, pp. 1619-1629, 2020.C. Malainou, S. M. Abdin, N. Lachmann, U. Matt, and S. Herold, "Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting," The Journal of Clinical Investigation, vol. 133, no. 19, 2023.
7. D. Chopra et al., "Overview of inflammation," in Inflammation Resolution and Chronic Diseases, Singapore: Springer Nature Singapore, 2024, pp. 1-18.
8. V. J. Clemente-Suárez et al., "New insights and potential therapeutic interventions in metabolic diseases," International Journal of Molecular Sciences, vol. 24, no. 13, p. 10672, 2023.
9. L. L. Alex and J. P. Michael, "Endothelium and smooth muscle interactions in hypertension," in Blood Vessel Changes in Hypertension Structure and Function, Volume II, CRC Press, 2024, pp. 43-70.
10. D. S. Goldstein, "The extended autonomic system, dyshomeostasis, and COVID-19," Clinical Autonomic Research, vol. 30, no. 4, pp. 299-315, 2020.
11. T. Iba, J. Helms, M. Levi, and J. H. Levy, "Inflammation, coagulation, and cellular injury in heat-induced shock," Inflammation Research, vol. 72, no. 3, pp. 463-473, 2023.
12. B. Saravi et al., "Capillary leak and endothelial permeability in critically ill patients: a current overview," Intensive Care Medicine Experimental, vol. 11, no. 1, p. 96, 2023.
13. G. I. Lee and M. W. Neumeister, "Pain: pathways and physiology," Clinics in Plastic Surgery, vol. 47, no. 2, pp. 173-180, 2020.
14. T. Pascart and E. Drouin, "Gout: the deeply rooted image of the self-inflicted disease of kings comes from misinterpreting history," The Lancet Rheumatology, vol. 7, no. 6, pp. e388-e390, 2025.
15. M. S. Merakeb, N. Bribi, R. Ferhat, and B. Yanat, "Inhibitory effects of linum usitatissimum alkaloid on inflammatory and nociceptive responses in mice," Current Bioactive Compounds, vol. 19, no. 2, pp. 56-62, 2023.
16. N. Zotova, Y. Zhuravleva, V. Chereshnev, and E. Gusev, "Acute and chronic systemic inflammation: features and differences in the pathogenesis, and integral criteria for verification and differentiation," International Journal of Molecular Sciences, vol. 24, no. 2, p. 1144, 2023
17. B. Katt and R. Coyle, "Thermal burns, chemical burns, and frostbite," in Review of Hand Surgery, E-Book, 2021, pp. 76.
18. S. Hannoodee and D. N. Nasuruddin, "Acute inflammatory response," in StatPearls [Internet], StatPearls Publishing, 2024.
19. K. S. Alharbi, S. K. Alenezi, and G. Gupta, "Pathophysiology and pathogenesis of inflammation," in Recent Developments in Anti-Inflammatory Therapy, Academic Press, 2023, pp. 1-9.
20. M. Pahwa, A. Cavanagh, and M. Vanstone, "Key informants in applied qualitative health research," Qualitative Health Research, vol. 33, no. 14, pp. 1251-1261, 2023.
21. C. L. R. Soares et al., "Biochemical aspects of the inflammatory process: A narrative review," Biomedicine & Pharmacotherapy, vol. 168, p. 115764, 2023.
22. C. Puricelli et al., "Platelets, protean cells with all-around functions and multifaceted pharmacological applications," International Journal of Molecular Sciences, vol. 24, no. 5, p. 4565, 2023.
23. C. Luo et al., "A review of the anti-inflammatory effects of rosmarinic acid on inflammatory diseases," Frontiers in Pharmacology, vol. 11, p. 153, 2020.
24. J. L. Harwood, "Polyunsaturated fatty acids: conversion to lipid mediators, roles in inflammatory diseases and dietary sources," International Journal of Molecular Sciences, vol. 24, no. 10, p. 8838, 2023.
25. G. Petrucci, M. A. Farhoud, and A. Habib, "Platelet thromboxane A2 and prostaglandin receptors," in Platelet Physiology I: Volume 1, Cham: Springer Nature Switzerland, 2025, pp. 291-302.
26. H. Zhao et al., "Inflammation and tumor progression: signaling pathways and targeted intervention," Signal Transduction and Targeted Therapy, vol. 6, no. 1, p. 263, 2021.
27. V. L. Petricevich and R. Abarca-Vargas, "Allamanda cathartica: a review of the phytochemistry, pharmacology, toxicology, and biotechnology," Molecules, vol. 24, no. 7, p. 1238, 2019.
28. I. Attaf and A. E. Cherbal, "The mechanistic aspects of the anti-inflammatory activity of Lavandula stoechas," Ph.D. dissertation, Université de jijel, Algeria, 2021.
29. Y. Y. Zhong, H. Wang, and Y. Y. Wang, "Nature's pain relievers: Unveiling the power of plant extracts against non-steroidal antiinflammatory drugs," Next Research, p. 100685, 2025.
30. S. Fareed, "Exploring the role of local glucocorticoid metabolism in osteoblasts during chronic inflammation," Ph.D. dissertation, University of Birmingham, UK, 2023.
31. J. H. Stone et al., "Inebilizumab for treatment of IgG4-related disease," New England Journal of Medicine, vol. 392, no. 12, pp. 1168-1177, 2025.
32. A. Nisar et al., "Phytochemicals in the treatment of inflammation-associated diseases: the journey from preclinical trials to clinical practice," Frontiers in Pharmacology, vol. 14, p. 1177050, 2023.
33. M. Mengistu, M. Kebebew, and V. B. Meyer-Rochow, "Ethnozoological study of medicinal animals used by the inhabitants of the Kucha District, Gamo Zone, Southern Ethiopia," Journal of Ethnobiology and Ethnomedicine, vol. 20, no. 1, p. 72, 2024.
34. D. Placha and J. Jampilek, "Chronic inflammatory diseases, anti-inflammatory agents and their delivery nanosystems," Pharmaceutics, vol. 13, no. 1, p. 64, 2021.
35. N. C. Uche-Okereafor, "Studies on Solanum Mauritianum Scopoli bacterial endophytes and the effects of their crude secondary metabolites on common pathogenic bacteria and resistant human cancer cells," Ph.D. dissertation, University of Johannesburg, South Africa, 2020.
36. U. O. Arunsi, O. E. Chioma, P. E. Etusim, and S. E. Owumi, "Indigenous Nigeria medicinal herbal remedies: A potential source for therapeutic against rheumatoid arthritis," Experimental Biology and Medicine, vol. 247, no. 13, pp. 1148-1178, 2022.
37. D. Jain et al., "Exploring synergistic benefits and clinical efficacy of turmeric in management of inflammatory and chronic diseases: A traditional Chinese medicine based review," Pharmacological Research-Modern Chinese Medicine, p. 100572, 2025.
38. M. F. Olaniyan, O. D. Olaniyi, F. Odegbemi, T. B. Olaniyan, and O. B. Odegbemi, "Isolation and purification techniques for bioactive compounds from Nigerian medicinal plants and their therapeutic applications," Discover Chemistry, vol. 2, no. 1, p. 13, 2025.
39. E. C. Pham, V. Van Doan, T. V. Le Thi, C. Van Ngo, and L. V. Van, "In vivo and in silico antihypertensive, anti-inflammatory, and analgesic activities of Vernonia amygdalina Del. leaf extracts," Heliyon, vol. 10, no. 19, 2024.
40. S. Fakhri et al., "Modulation of TLR/NF-κB/NLRP signaling by bioactive phytocompounds: A promising strategy to augment cancer chemotherapy and immunotherapy," Frontiers in Oncology, vol. 12, p. 834072, 2022.