Inflammatory Myofibroblastic Tumors (IMT): Case Series with Emphasis on ALK Negative IMT

Authors : Dr. Lopa Mudra Kakoti, Dr. Jagannath Dev Sharma, Dr. B. Borooah

Volume/Issue : Volume 4 - 2019, Issue 11 - November

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IMT represents the neoplastic subset of the family of inflammatory pseudotumors, an umbrella term for spindle cell proliferations of uncertain histogenesis with a variable inflammatory component. It is important to recognise this entity for their unpredictable recurrent behaviour. We present a series of 7 cases of IMT involving different organs.Most of the patients were middle aged female. Oral cavity was the most frequent site followed by upper limb, lung and intestine. Recurrence was seen in patients with upper limb IMTs. IHC Alk was positive in only one case. Out of 7 cases, 4 cases had repeated negative biopsies. There is a long list of morphological differentials to exclude before diagnosing IMT. IHC can help to arrive at the diagnosis, but not without pitfalls and these cases highlight the need for clinicopathological and radiological correlation along with a high index of suspicion, and of course, the use of ancillary techniques such as IHC, FISH would adjunct to arrive at the accurate diagnosis.Alk negative IMT remains a masquerading entity about their diagnosis, pathology ( ? infective? neoplastic) and biological behaviour requiring more detailed genetic analysis and immunohistochemical studies for further classification.

Keywords : Myofibroblast, Inflammatory, Alk, Negative, Any, WHO,Intermediate


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