Inflammatory Myofibroblastic Tumors (IMT): Case Series with Emphasis on ALK Negative IMT


Authors : Dr. Lopa Mudra Kakoti, Dr. Jagannath Dev Sharma, Dr. B. Borooah

Volume/Issue : Volume 4 - 2019, Issue 11 - November

Google Scholar : https://goo.gl/DF9R4u

Scribd : https://bit.ly/2tfozBg

IMT represents the neoplastic subset of the family of inflammatory pseudotumors, an umbrella term for spindle cell proliferations of uncertain histogenesis with a variable inflammatory component. It is important to recognise this entity for their unpredictable recurrent behaviour. We present a series of 7 cases of IMT involving different organs.Most of the patients were middle aged female. Oral cavity was the most frequent site followed by upper limb, lung and intestine. Recurrence was seen in patients with upper limb IMTs. IHC Alk was positive in only one case. Out of 7 cases, 4 cases had repeated negative biopsies. There is a long list of morphological differentials to exclude before diagnosing IMT. IHC can help to arrive at the diagnosis, but not without pitfalls and these cases highlight the need for clinicopathological and radiological correlation along with a high index of suspicion, and of course, the use of ancillary techniques such as IHC, FISH would adjunct to arrive at the accurate diagnosis.Alk negative IMT remains a masquerading entity about their diagnosis, pathology ( ? infective? neoplastic) and biological behaviour requiring more detailed genetic analysis and immunohistochemical studies for further classification.

Keywords : Myofibroblast, Inflammatory, Alk, Negative, Any, WHO,Intermediate

CALL FOR PAPERS


Paper Submission Last Date
31 - December - 2021

Paper Review Notification
In 1-2 Days

Paper Publishing
In 2-3 Days

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe