Authors :
Júlia Ribeiro Campos ; Lucas Marques Soares da Silva; Murilo Porfírio de Aguiar; Paula Cristina Silva; Tatiane Marques
Volume/Issue :
Volume 7 - 2022, Issue 7 - July
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3cOPZVF
DOI :
https://doi.org/10.5281/zenodo.6930452
Abstract :
Introduction: Stress has been accompanying
human beings since the beginning of their existence,
worsening after Industrial Revolution. Due to current
circumstances, stress is much discussed, however, it is
restricted to psychosocial problems and rarely related to
organic diseases such as cancer. According to Instituto
Nacional de Câncer, by the end of 2022 approximately 2
million new cancer cases will be diagnosed in Brazil.
Objective: Understand stress consequences on immune
system correlating with tumorigenesis. Methods:
Searches on SCIELO, LILACS, PubMed, BIREME and
Academic Google databases, using as descriptors “Stress
Physiology”; “Stress Influence on immune system”;
“Immunovigilance”; "Basic tumor immunology;"
“Immune surveillance”; “Tumor microenvironment”;
“Immunosuppression by stress”;
“Psychoneuroimmunology”. Results: Tumorigenesis is
defined as malignant mutations accumulation
characterized by exacerbated cell multiplication. To
prevent this pathological state from materializing the
organism has physiological barriers, the first is found in
the cell cycle, where at certain points DNA quality is
evaluated, when not approved the division is interrupted.
If these mechanisms fail, immune system recognizes and
destroys the mutant cell. Deficient immune response
causes altered cells to develop escape mechanisms. In this
context, stress is cited as an important
immunosuppressant. Studies show deleterious effects of
glucocorticoids on leukocytes, in Th1/Th2 responses
imbalances and instability in humoral response.
Conclusion: Ineffective immune response is a major
contributor to tumorigenesis, which is vulnerable to stress
and hormones released in this state.
Keywords :
Psychological Stress; Neoplasms; Immunologic monitoring; Psychoneuroimmunology
Introduction: Stress has been accompanying
human beings since the beginning of their existence,
worsening after Industrial Revolution. Due to current
circumstances, stress is much discussed, however, it is
restricted to psychosocial problems and rarely related to
organic diseases such as cancer. According to Instituto
Nacional de Câncer, by the end of 2022 approximately 2
million new cancer cases will be diagnosed in Brazil.
Objective: Understand stress consequences on immune
system correlating with tumorigenesis. Methods:
Searches on SCIELO, LILACS, PubMed, BIREME and
Academic Google databases, using as descriptors “Stress
Physiology”; “Stress Influence on immune system”;
“Immunovigilance”; "Basic tumor immunology;"
“Immune surveillance”; “Tumor microenvironment”;
“Immunosuppression by stress”;
“Psychoneuroimmunology”. Results: Tumorigenesis is
defined as malignant mutations accumulation
characterized by exacerbated cell multiplication. To
prevent this pathological state from materializing the
organism has physiological barriers, the first is found in
the cell cycle, where at certain points DNA quality is
evaluated, when not approved the division is interrupted.
If these mechanisms fail, immune system recognizes and
destroys the mutant cell. Deficient immune response
causes altered cells to develop escape mechanisms. In this
context, stress is cited as an important
immunosuppressant. Studies show deleterious effects of
glucocorticoids on leukocytes, in Th1/Th2 responses
imbalances and instability in humoral response.
Conclusion: Ineffective immune response is a major
contributor to tumorigenesis, which is vulnerable to stress
and hormones released in this state.
Keywords :
Psychological Stress; Neoplasms; Immunologic monitoring; Psychoneuroimmunology
