Insight of Epigenetics in Autoimmunity and Allergies


Authors : Aqsa Yahya; Iqra Yahya; Samreen Rana; Samia Dastgeer; Muqaddas Rana; Sadia Tabassum; Laraib Ali

Volume/Issue : Volume 8 - 2023, Issue 3 - March

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://bit.ly/3MGEXS6

DOI : https://doi.org/10.5281/zenodo.7825016

Abstract : Epigenetic processes include DNA methylation, chromatin changes, and micro RNA-based signaling all play a role in controlling genome activity. Epigenetic regulation is present in practically every component of immunity, whether for host defense or in the form of interference resistance. These cycles are crucial in mediating dynamic reactions to the environment over the life span of an individual, although we are only beginning to grasp how dysregulation in these pathways may play a role in autoimmune disorders. The epigenetic mechanisms that affect immune development and, by extension, an individual's health and the course of disease, are covered in a clear and succinct manner here.

Keywords : Autoimmune Diseases, Epigenetics, DNA Methylation, Histone Modification, and mRNA.

Epigenetic processes include DNA methylation, chromatin changes, and micro RNA-based signaling all play a role in controlling genome activity. Epigenetic regulation is present in practically every component of immunity, whether for host defense or in the form of interference resistance. These cycles are crucial in mediating dynamic reactions to the environment over the life span of an individual, although we are only beginning to grasp how dysregulation in these pathways may play a role in autoimmune disorders. The epigenetic mechanisms that affect immune development and, by extension, an individual's health and the course of disease, are covered in a clear and succinct manner here.

Keywords : Autoimmune Diseases, Epigenetics, DNA Methylation, Histone Modification, and mRNA.

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