Integrated Nutritional Approaches for Hormonal Modulation During the Perimenopausal Transition


Authors : Aditi Vohra

Volume/Issue : Volume 10 - 2025, Issue 6 - June


Google Scholar : https://tinyurl.com/5yt88m5j

DOI : https://doi.org/10.38124/ijisrt/25jun1773

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Note : Google Scholar may take 30 to 40 days to display the article.


Abstract : Perimenopause signifies a major transitional period in a woman’s life, characterized by fluctuating levels of estrogen and progesterone that give rise to various physiological and psychological symptoms. These include hot flashes, night sweats, mood swings, sleep disturbances, and an increased risk of chronic illnesses such as osteoporosis and cardiovascular diseases. Although hormone replacement therapy (HRT) has been widely utilized to mitigate these effects, growing concerns regarding its safety have fueled interest in non-pharmacological alternatives. Among these, nutritional and lifestyle interventions stand out as promising, sustainable strategies. This paper presents a comprehensive examination of integrated nutritional approaches for hormonal modulation during perimenopause. It emphasizes the synergistic effects of specific micronutrients, notably magnesium, as well as broader dietary patterns such as the Mediterranean and plant- based diets. Lifestyle modifications, including physical activity, stress management, and sleep hygiene, are also explored for their role in enhancing hormonal balance. The interplay between diet, the gut microbiome, and estrogen metabolism is also examined. The evidence suggests that a personalized, culturally relevant approach incorporating these strategies can significantly improve quality of life and long-term health outcomes for perimenopausal women.

Keywords : Perimenopause, Hormonal Balance, Magnesium, Mediterranean Diet, Plant-Based Diet.

References :

  1. Messina, M., “Soy foods and isoflavones as part of the diet for perimenopausal women,” Nutrition Today, vol. 49, no. 6, pp. 276–282, Nov./Dec. 2014.
  2. Salinas, G., and A. López-Sobaler, “Effects of phytoestrogens on menopausal symptoms: A meta-analysis,” Maturitas, vol. 98, pp. 45–52, Jan. 2017.
  3. Colacurci, N., E. Fornaro, A. De Franciscis, L. Sepe, and A. Troisi, “Effects of phytoestrogens on menopausal symptoms: A randomized controlled trial,” Maturitas, vol. 48, no. 3, pp. 301–309, Mar. 2004.
  4. Walker, A. F., T. De Souza, M. P. Vickers, J. Abeyasekera, and P. R. Collins, “Magnesium supplementation improves mood in perimenopausal women,” Journal of Women’s Health, vol. 9, no. 3, pp. 315–320, Mar. 2000.
  5. De Souza, M. J., N. C. Arceo, and L. O. McGrath, “The role of magnesium in menopausal symptomatology,” American Journal of Obstetrics and Gynecology, vol. 182, no. 2, pp. 505–510, Feb. 2000.
  6. Lukert, B. P., and T. R. Raisz, “Vitamin D deficiency and secondary hyperparathyroidism in elderly populations,” Journal of Clinical Endocrinology & Metabolism, vol. 64, no. 1, pp. 95–100, Jan. 1987.
  7. Lips, P., “Vitamin D physiology and clinical implications during perimenopause,” Osteoporosis International, vol. 23, no. 2, pp. 421–426, Feb. 2012.
  8. Lucas, M., M. Asselin, and M. M. Tremblay, “Omega-3 supplementation for mood improvement during perimenopause: A randomized controlled trial,” American Journal of Clinical Nutrition, vol. 89, no. 3, pp. 641–651, Mar. 2009.
  9. Sanfilippo, C., G. P. Capodicasa, A. Mauro, L. Anastasi, and R. Cavallaro, “Neuroendocrine modulation and the role of omega-3 fatty acids: Emerging evidence in menopausal women,” Neurobiology of Aging, vol. 32, no. 4, pp. 765–777, Apr. 2011.
  10. Komal, F., R. Kumar, and P. Chhabra, “Omega-3 fatty acids and hormonal modulation in female rats: A study on dietary interventions,” Journal of Functional Foods, vol. 68, p. 103905, July 2020.
  11. Panagiotakos, D. B., C. Pitsavos, A. Zampelas, and C. Stefanadis, “Adherence to Mediterranean diet and menopausal symptom frequency,” Journal of Nutrition, vol. 137, no. 6, pp. 1290–1293, June 2007.
  12. Sofi, F., R. Cesari, L. Abbate, R. Gensini, and G. Casini, “Adherence to Mediterranean diet and health status: Meta-analysis,” BMJ, vol. 337, p. a1344, Sept. 2008.
  13. Turnbaugh, P. J., R. E. Ley, M. A. Mahowald, V. Magrini, E. R. Mardis, and J. I. Gordon, “An obesity-associated gut microbiome with increased capacity for energy harvest,” Nature, vol. 444, pp. 1027–1031, Dec. 2006.
  14. Sharma, S., N. Batra, and A. A. Dixit, “Plant-based diets and menopausal health: A review,” Journal of Midlife Health, vol. 13, no. 4, pp. 208–215, Oct.–Dec. 2022.
  15. Elavsky, S., and E. McAuley, “Physical activity, symptoms, esteem, and life satisfaction during menopause,” Maturitas, vol. 57, no. 2, pp. 132–140, Oct. 2007.
  16. Woods, N. F., K. Mitchell, M. Adams, and L. Percival, “Mind-body interventions for menopause: A randomized trial,” Journal of Midwifery & Women’s Health, vol. 54, no. 1, pp. 31–40, Jan. 2009.
  17. Perna, S., A. Spadaccini, and M. Rondanelli, “Soy and cardiovascular health in menopausal women: A systematic review,” Nutrients, vol. 8, no. 11, p. 674, Nov. 2016.
  18. Lemacks, J. L., and D. K. Hughes, “Dietary calcium to protein ratio and hormonal effects in midlife women,” Nutrition Research, vol. 32, no. 9, pp. 666–672, Sept. 2012.
  19. Zineb, F., M. Reda, and R. Lahlou, “Vitamin D receptor expression and its role in hormone regulation,” Endocrine Research, vol. 24, pp. 67–75, Feb. 1998.
  20. Maarouf, M., M. H. Chehab, N. Bacha, and K. Alsaadi, “Effects of omega-3 fatty acids in women with polycystic ovary syndrome: A clinical review,” Clinical Nutrition ESPEN, vol. 29, pp. 1–8, June 2019.
  21. Plottel, C. S., and M. J. Blaser, “Microbiome and estrogen metabolism: The role of the estrobolome,” Nature Reviews Endocrinology, vol. 7, pp. 725–731, Dec. 2011.
  22. Menke, A., K. Arora, and M. B. Gomez, “Gut microbiota and menopausal transition,” Journal of Women’s Health, vol. 29, no. 6, pp. 772–780, June 2020.
  23. WHO, “Physical activity guidelines,” World Health Organization, Geneva, 2020.

Perimenopause signifies a major transitional period in a woman’s life, characterized by fluctuating levels of estrogen and progesterone that give rise to various physiological and psychological symptoms. These include hot flashes, night sweats, mood swings, sleep disturbances, and an increased risk of chronic illnesses such as osteoporosis and cardiovascular diseases. Although hormone replacement therapy (HRT) has been widely utilized to mitigate these effects, growing concerns regarding its safety have fueled interest in non-pharmacological alternatives. Among these, nutritional and lifestyle interventions stand out as promising, sustainable strategies. This paper presents a comprehensive examination of integrated nutritional approaches for hormonal modulation during perimenopause. It emphasizes the synergistic effects of specific micronutrients, notably magnesium, as well as broader dietary patterns such as the Mediterranean and plant- based diets. Lifestyle modifications, including physical activity, stress management, and sleep hygiene, are also explored for their role in enhancing hormonal balance. The interplay between diet, the gut microbiome, and estrogen metabolism is also examined. The evidence suggests that a personalized, culturally relevant approach incorporating these strategies can significantly improve quality of life and long-term health outcomes for perimenopausal women.

Keywords : Perimenopause, Hormonal Balance, Magnesium, Mediterranean Diet, Plant-Based Diet.

CALL FOR PAPERS


Paper Submission Last Date
31 - July - 2025

Video Explanation for Published paper

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe