Integrative Approach to PCOS: Pharmacological Insights from Siddha Formulations


Authors : A. Abarnadevika; R. B. Miruthunguptha; N. Aravindhan; Dr. G. Ariharasivakumar

Volume/Issue : Volume 10 - 2025, Issue 8 - August


Google Scholar : https://tinyurl.com/y3m3648h

Scribd : https://tinyurl.com/4emjbmjb

DOI : https://doi.org/10.38124/ijisrt/25aug1216

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Abstract : Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine and metabolic disorder affecting up to 20% of women in India. Conventional therapies often fail to address its multifactorial etiology and have limitations due to side effects. Siddha medicine, an ancient South Indian system, offers multimodal interventions that target hormonal, metabolic, and inflammatory pathways. This review aimed to evaluate the pharmacological basis, clinical evidence, and integration prospects of Siddha formulations in PCOS management.We conducted a scoping review of Siddha formulations commonly used in PCOS, such as Ashokarishtam, Karisalai Karpam, Amukkara Choornam, and Keezhanelli, analyzing preclinical and clinical evidence, proposed mechanisms of action, and safety considerations. Data were extracted from published experimental and clinical studies, Siddha classics, and pharmacological reviews. Siddha medicine offers a promising, culturally sensitive adjunct in PCOS management, addressing its complex pathophysiology. Well-designed trials and standardization are needed to substantiate efficacy and ensure safety for wider clinical adoption.

Keywords : Polycystic Ovary Syndrome; Siddha Medicine; Herbal Therapy; Integrative Healthcare; Insulin Resistance.

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  94. Sharma R, Verma N, Gupta S, Singh P. Effects of Withania somnifera on hormonal regulation in PCOS: A randomized controlled trial. J Ethnopharmacol. 2020;249:112399.
  95. Verma N, Sharma R, Rajan S, Nair S. Clinical efficacy of Saraca asoca in the treatment of menstrual disorders and PCOS. J Tradit Complement Med. 2017;7(2):205–210.
  96. Rao M, Nair SC, Thomas V, Menon A. Metabolic improvements with Phyllanthus niruri in PCOS: Evidence from clinical and experimental studies. Phytother Res. 2020;34(6):1458–1466.

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine and metabolic disorder affecting up to 20% of women in India. Conventional therapies often fail to address its multifactorial etiology and have limitations due to side effects. Siddha medicine, an ancient South Indian system, offers multimodal interventions that target hormonal, metabolic, and inflammatory pathways. This review aimed to evaluate the pharmacological basis, clinical evidence, and integration prospects of Siddha formulations in PCOS management.We conducted a scoping review of Siddha formulations commonly used in PCOS, such as Ashokarishtam, Karisalai Karpam, Amukkara Choornam, and Keezhanelli, analyzing preclinical and clinical evidence, proposed mechanisms of action, and safety considerations. Data were extracted from published experimental and clinical studies, Siddha classics, and pharmacological reviews. Siddha medicine offers a promising, culturally sensitive adjunct in PCOS management, addressing its complex pathophysiology. Well-designed trials and standardization are needed to substantiate efficacy and ensure safety for wider clinical adoption.

Keywords : Polycystic Ovary Syndrome; Siddha Medicine; Herbal Therapy; Integrative Healthcare; Insulin Resistance.

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