Authors : Abdullah Yahya Alkinani; Wong Jest Phia, Westwood Clini

Volume/Issue : Volume 9 - 2024, Issue 5 - May

Google Scholar : https://tinyurl.com/3aju7pf4

Scribd : https://tinyurl.com/44wea648

DOI : https://doi.org/10.38124/ijisrt/IJISRT24MAY1166

Abstract : The gut-brain axis, a bidirectional communication system between the gut and the brain, has garnered increasing attention in recent years for its role in influencing various aspects of health and disease. Central to this axis is the gut microbiome, a complex community of microorganisms inhabiting the gastrointestinal tract. This review explores the intricate interactions between gut bacteria and the brain, focusing on their impact on neurological and psychiatric disorders. Specifically, it delves into the involvement of gut bacteria in conditions such as multiple sclerosis (MS), cerebrovascular diseases, stress, depression, and migraine. Furthermore, it discusses the methods used to assess gut bacteria and the potential therapeutic interventions targeting the microbiome-brain axis.

References :

1. Mohajeri, M. H., La Fata, G., Steinert, R. E., & Weber, P. (2018, April 26). Relationship between the gut microbiome and brain function. OUP Academic. https://academic.oup.com/nutritionreviews/article/76/7/481/4985887
2. Deidda, G., & Biazzo, M. (2021, September 16). Gut and brain: Investigating physiological and pathological interactions between microbiota and brain to gain new therapeutic avenues for brain diseases. Frontiers. https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.753915/full
3. Mulder, D., Aarts, E., Arias Vasquez, A., & Bloemendaal, M. (2023, July 21). A systematic review exploring the association between the human Gut Microbiota and brain connectivity in health and disease. Nature News. https://www.nature.com/articles/s41380-023-02146-4
4. Author links open overlay panelGarvita Sharma a, a, b, c, d, e, f, g, h, i, j, AbstractHuntington’s disease (HD) is a complex progressive neurodegenerative disorder affected by genetic, Walker, F. O., Ross, C. A., Clemente, J. C., Koh, A., Ridlon, J. M., Liu, L., Socala, K., … Vugt, J. P. van. (2023, June 24). Gut microbiota dysbiosis and Huntington’s disease: Exploring the gut-brain axis and novel microbiota-based interventions. Life Sciences. https://www.sciencedirect.com/science/article/abs/pii/S0024320523005179
5. Team, M. (n.d.). Frontiers in physiology. Frontiers. https://www.frontiersin.org/journals/physiology
6. Chen, H.-M., Chung, Y.-C. E., Chen, H.-C., Liu, Y.-W., Chen, I.-M., Lu, M.-L., Hsiao, F. S.-H., Chen, C.-H., Huang, M.-C., Shih, W.-L., & Kuo, P.-H. (2022, December 5). Exploration of the relationship between gut microbiota and fecal micrornas in patients with major depressive disorder. Nature News. https://www.nature.com/articles/s41598-022-24773-7
7. Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020, January 17). The progress of gut microbiome research related to Brain Disorders - Journal of Neuroinflammation. SpringerLink. https://link.springer.com/article/10.1186/s12974-020-1705-z
8. Zhu, X., Li, B., Lou, P., Dai, T., Chen, Y., Zhuge, A., Yuan, Y., & Li, L. (2021, July 3). The relationship between the gut microbiome and Neurodegenerative Diseases - Neuroscience Bulletin. SpringerLink. https://link.springer.com/article/10.1007/s12264-021-00730-8
9. Author links open overlay panelVadim Osadchiy, Background & AimsBased largely on results from preclinical studies, Yano, J. M., Haghikia, A., Goehler, L. E., Marcelin, G., Cani, P. D., Chimerel, C., Vogel, C. F., Sampson, T. R., Kennedy, P. J., Ivanov, I. I., Mayer, E. A., Desai, M. S., Brown, A. J., Varatharaj, A., Houlden, A., Heijtz, R. D., Backhed, F., … Khakh, B. S. (2018a, October 4). The gut–brain axis and the microbiome: Mechanisms and clinical implications. Clinical Gastroenterology and Hepatology. https://www.sciencedirect.com/science/article/abs/pii/S1542356518310814
10. Fraher, M. H., O’Toole, P. W., & Quigley, E. M. M. (2012, March 27). Techniques used to characterize the gut microbiota: A guide for the clinician. Nature News. https://www.nature.com/articles/nrgastro.2012.44