Authors : Vahid Hosseini; Seyed Masoud Ghoreishi Mokri; Dalia hafezghoran; Bahareh Karimi; Anastasia Aleksandrovna Anashkina; Anna Borisovna Yazykova

Volume/Issue : Volume 9 - 2024, Issue 5 - May

Google Scholar : https://tinyurl.com/3debx63a

Scribd : https://tinyurl.com/2hr9puej

DOI : https://doi.org/10.38124/ijisrt/IJISRT24MAY1087

Abstract : The drug delivery systems that were used in the past were done without any control over the time, place and speed of drug release, and this caused the amount of drug released in the blood to fluctuate, that is, the concentration of the drug in the blood could vary from The therapeutic range will be exceeded and its side effects will also increase. Therefore, with targeted medicine, it is possible to control the place of drug release, its speed and time, and minimize the side effects caused by the drug. In this regard, in this research, the natural hydrogel extracted from the Plantago ovate plant as one of the drug carriers in the body environment in order to increase the efficiency and reduce the degradation of the drug, prevent the side effects caused by the use of the drug and increase the access to the drug and improve Its effect was investigated at the lesion site. In this context, after extracting the natural hydrogel from Plantago ovate plant, the swelling rate of Plantago ovate gel powder was investigated at different pH, the FT-IR spectrum obtained from Plantago ovate hydrogel and the swelling rate of Plantago ovate mucilage at different pH were investigated. Therefore, the obtained results indicate that natural polysaccharides can be used as a natural drug carrier in drug delivery systems due to their high biocompatibility in the body environment, non-toxicity and cheapness.

Keywords : Targeted Drug Delivery - Plantago Ovate Plant - Natural Hydrogel - Polymer Nanoparticles.

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