Authors :
Dr. N. Junior Sundaresh; Sanjana B.; Priyadarshini R.; Dr. K. Kathiresan
Volume/Issue :
Volume 10 - 2025, Issue 8 - August
Google Scholar :
https://tinyurl.com/yc5xrzdh
Scribd :
https://tinyurl.com/yz77u6xp
DOI :
https://doi.org/10.38124/ijisrt/25aug990
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Abstract :
Diabetic foot ulcers (DFUs) are amongst the most critical diabetes mellitus complications and commonly result in
infection, hospitalization, and amputation. Glycaemic control, whose degree is commonly assayed by HbA1c at regular
intervals, has been considered as a wound healing factor of prime significance, although with a direct effect on ulcer healing
being questioned. Objective: The aim of the study was to investigate the relationship between glycaemic control and healing
rate of patients' diabetic foot ulcers. Methods: Prospective observational study among diabetic patients hospitalized with
foot ulcer. Baseline demographic data, glycaemic control parameters (e.g., HbA1c and fasting blood sugar), and
characteristics of the ulcers were noted. Rate of healing of ulcer was monitored during a given follow-up period, and
statistical correlation between glycaemic parameters and healing outcome was analysed. Results: The research proved a
strong inverse correlation between ulcer healing rates and HbA1c levels. Patients with improved glycaemic control (HbA1c
< 7.5%) exhibited quicker and more successful healing than those with poor control. Furthermore, other variables like the
duration of diabetes, peripheral neuropathy, and infection status also affected the healing rates. Conclusion: Glycaemic
control is a significant predictor of diabetic foot ulcer healing. Monitoring and optimisation of blood glucose on a regular
basis is likely to promote wound healing and decrease complications, once again showing the significance of well-coordinated
diabetic care.
Keywords :
Diabetic Foot Ulcer, HbA1c, Glycaemic Control, Ulcer Healing, Diabetes Mellitus, Wound Healing, Chronic Wounds, Healing Outcomes.
References :
- Lavery, L. A., et al. (2014). Reevaluating the way we classify the diabetic foot: restructuring the diabetic foot risk classification system of the International Working Group on the Diabetic Foot. Diabetes Care, 37(3), 855-862. https://doi.org/10.2337/dc13-1203.
- Zubair, M., Malik, A., & Ahmad, J. (2015). Glycosylated hemoglobin in diabetic foot and its association with outcome. International Journal of Endocrinology, 2015, Article ID 847193. https://doi.org/10.1155/2015/847193.
- Game, F. L., et al. (2016). A systematic review of interventions to enhance the healing of chronic ulcers of the foot in diabetes. Diabetes/Metabolism Research and Reviews, 32(S1), 154-168. https://doi.org/10.1002/dmrr.2707.
- Margolis, D. J., et al. (2002). The effectiveness of diabetic foot ulcer care and the role of gender. Wound Repair and Regeneration, 10(6), 332-338. https://doi.org/10.1046/j.1524-475X.2002.10605.
- Smith, D. G., et al. (2013). The influence of smoking on diabetic wound healing. Plastic and Reconstructive Surgery, 131(5), 940e–941e. https://doi.org/10.1097/PRS.0b013e3182865cd2.
- Armstrong, D. G., Boulton, A. J., & Bus, S. A. (2017). Diabetic foot ulcers and their recurrence. New England Journal of Medicine, 376(24), 2367–2375. https://doi.org/10.1056/NEJMra1615439.
- Lipsky, B. A., et al. (2012). 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clinical Infectious Diseases, 54(12), e132–e173. https://doi.org/10.1093/cid/cis346.
- Prompers, L., et al. (2008). High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Diabetologia, 50(1), 18–25. https://doi.org/10.1007/s00125-006-0491-1.
- Jeffcoate, W. J., & Harding, K. G. (2003). Diabetic foot ulcers. The Lancet, 361(9368), 1545–1551. https://doi.org/10.1016/S0140-6736(03)13169-8.
- Reiber, G. E., et al. (1999). Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care, 22(1), 157–162. https://doi.org/10.2337/diacare.22.1.157.
- Zhang, Y., et al. (2017). The role of glycemic control in wound healing in patients with diabetic foot ulcers: a prospective study. Journal of Diabetes Research, 2017, Article ID 2541956. https://doi.org/10.1155/2017/2541956.
- Oyibo, S. O., et al. (2001). The relationship between blood glucose control and wound healing in patients with diabetic foot ulcers. Diabetic Medicine, 18(4), 299–304. https://doi.org/10.1046/j.1464-5491.2001.00484.
- Basit, A., et al. (2013). Role of HbA1c in the prediction of healing in diabetic foot ulcers. Journal of Pakistan Medical Association, 63(12), 1583–1585.
- Tentolouris, N., et al. (2009). The effects of smoking on healing of foot ulcers in diabetic patients. International Wound Journal, 6(3), 271–275. https://doi.org/10.1111/j.1742-481X.2009.00597.
- Alexiadou, K., & Doupis, J. (2012). Management of diabetic foot ulcers. Diabetes Therapy, 3(1), 4. https://doi.org/10.1007/s13300-012-0004-9.
Diabetic foot ulcers (DFUs) are amongst the most critical diabetes mellitus complications and commonly result in
infection, hospitalization, and amputation. Glycaemic control, whose degree is commonly assayed by HbA1c at regular
intervals, has been considered as a wound healing factor of prime significance, although with a direct effect on ulcer healing
being questioned. Objective: The aim of the study was to investigate the relationship between glycaemic control and healing
rate of patients' diabetic foot ulcers. Methods: Prospective observational study among diabetic patients hospitalized with
foot ulcer. Baseline demographic data, glycaemic control parameters (e.g., HbA1c and fasting blood sugar), and
characteristics of the ulcers were noted. Rate of healing of ulcer was monitored during a given follow-up period, and
statistical correlation between glycaemic parameters and healing outcome was analysed. Results: The research proved a
strong inverse correlation between ulcer healing rates and HbA1c levels. Patients with improved glycaemic control (HbA1c
< 7.5%) exhibited quicker and more successful healing than those with poor control. Furthermore, other variables like the
duration of diabetes, peripheral neuropathy, and infection status also affected the healing rates. Conclusion: Glycaemic
control is a significant predictor of diabetic foot ulcer healing. Monitoring and optimisation of blood glucose on a regular
basis is likely to promote wound healing and decrease complications, once again showing the significance of well-coordinated
diabetic care.
Keywords :
Diabetic Foot Ulcer, HbA1c, Glycaemic Control, Ulcer Healing, Diabetes Mellitus, Wound Healing, Chronic Wounds, Healing Outcomes.