Authors : Jessel Grace M. Casiple; Shamlah A. Amerol; Janelle Kyla A. Montebon; Jowairiah R. Mangontra; Junnin Gay L. Garay

Volume/Issue : Volume 10 - 2025, Issue 7 - July

Google Scholar : https://tinyurl.com/3fhudbtb

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DOI : https://doi.org/10.38124/ijisrt/25jul1121

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Abstract : The leaves of Barringtonia asiatica (Lecythidaceae) have long been employed in traditional medicine for their therapeutic benefits, including anti-inflammatory properties. This study evaluated the anti-inflammatory effects of ethanolic leaf extracts of B. asiatica in vivo using carrageenan-induced paw edema in Swiss albino mice. Mice were administered extract concentrations of 25%, 50%, and 75%, while diclofenac sodium served as a positive control. Phytochemical analysis revealed the presence of flavonoids, saponins, and other bioactive constituents. The 75% extract demonstrated significant anti-inflammatory effects, comparable to diclofenac. Acute oral toxicity testing confirmed the extract's safety. These findings support the traditional medicinal use of B. asiatica and its potential as a safe, plant-based anti-inflammatory agent.

Keywords : Barringtonia asiatica, Anti-Inflammatory, Ethanolic Extract, Carrageenan, Paw Edema, Phytochemicals.

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