In-Vitro Anti-Diabetic Activity of Acalypha indica by Using Α - Amylase Inhibition Assay


Authors : G. Supriya Reddy; Akula Sai Nandini; Bommidi Haripriya; Annela Shirisha; Keesari Sampath; V. V. Rajesham; T. Rama Rao

Volume/Issue : Volume 8 - 2023, Issue 11 - November

Google Scholar : https://tinyurl.com/36uyearc

Scribd : https://tinyurl.com/458c7rjs

DOI : https://doi.org/10.5281/zenodo.10353398

Abstract : Medicinal plants have been used as remedies for many illnesses for a very long time all throughout the world. Acalypha indica is a kind of plant with an inflorescence resembling catkins. Despite being a weed, Acalypha indica is recognized by the locals as a valuable source of medication for a number of therapeutic therapies. Acalypha indica Linn is a plant that may have the ability to lower blood glucose levels. Acalypha indica Linn is one of the alternative herbal treatments for type-2 diabetes mellitus. Acalypha indica extract can be used to treat type-2 diabetes in addition to metformin therapy as well as to avoid insulin resistance in healthy individuals. According to this research, the findings of the alpha amylase enzyme test using the ethanol and pet ether extracts of the Acalypha indica plant suggested possible anti-diabetic efficacy based on its inhibitory activity (%). When acarbose and the potential for its anti-diabetic effects were evaluated, pet ether extract shown a better potential for suppressing alpha amylase's enzymatic activity. This was in contrast to ethanol extract.

Keywords : Acalypha indica, Diabetes, Phytochemical Screening, α - amylase inhibition assay.

Medicinal plants have been used as remedies for many illnesses for a very long time all throughout the world. Acalypha indica is a kind of plant with an inflorescence resembling catkins. Despite being a weed, Acalypha indica is recognized by the locals as a valuable source of medication for a number of therapeutic therapies. Acalypha indica Linn is a plant that may have the ability to lower blood glucose levels. Acalypha indica Linn is one of the alternative herbal treatments for type-2 diabetes mellitus. Acalypha indica extract can be used to treat type-2 diabetes in addition to metformin therapy as well as to avoid insulin resistance in healthy individuals. According to this research, the findings of the alpha amylase enzyme test using the ethanol and pet ether extracts of the Acalypha indica plant suggested possible anti-diabetic efficacy based on its inhibitory activity (%). When acarbose and the potential for its anti-diabetic effects were evaluated, pet ether extract shown a better potential for suppressing alpha amylase's enzymatic activity. This was in contrast to ethanol extract.

Keywords : Acalypha indica, Diabetes, Phytochemical Screening, α - amylase inhibition assay.

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