Authors :
Dr. Yashodha D; Dr. Diganta Hazarika
Volume/Issue :
Volume 8 - 2023, Issue 4 - April
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://bit.ly/42FYjLN
Abstract :
Surprising progress has been made in the
biology of breast cancer in recent years. Breast cancer is
the commonest cancer in women worldwide. In India it is
the second most common female malignancy , accounting
28% of all malignancies in women. The age standardized
rate is 54.9 per 1,00,000 per year. Biomarkers expression
in breast cancer is used as a prognostic indicator and
predictor of response to hormonal and chemotherapy.
To date, the leading parameters that guide therapy in
breast cancer are estrogen receptor (ER), progesterone
receptor (PR) and human epidermal growth factor
(HER2neu). In recent years, gene expression analysis
studies have demonstrated the vitality of proliferation
signatures not only in the prognosis of breast cancer but
also as a predictive response to subsequent therapy
,(3,4,5 ). The aim of the current study is to analyse the
correlation between various pathological prognostic
markers of Invasive ductal carcinoma (IDC) of the
breast with Ki67 index and provide a rough estimate of
the cut-off values for the latter. The methodology used is
formalin fixed paraffin embedded tissue blocks and
slides (H&E histology and Immunohistochemistry) were
retrieved and reviewed. Re-cutting and re-staining of
faded material were carried out when needed. This is a
two-year study from February 2015 to February 2017.
Data were analysed using “SPSS Version 23.” The
outcomes of biomarker analysis showed that
immunohistochemical expression of Ki67 appears to be
associated with absence of ER, PR expression and
Her2neu positivity. These findings underlined the
relationship between Ki67, a relatively new biological
marker which is a valuable predictive factor in invasive
ductal carcinomas of breast. index” and the (p =0.04),
PR and Ki 67 (p=0.026). A slightly higher incidence of
Her-2/neu positivity was seen, and there was a significant
connection between “HER2-Neu” and “Ki-67” index and
the (p =0.029). The molecular groups and Ki67 have no
discernible relationship.
Keywords :
Ki-67, Prognostic Markers, Invasive Ductal Carcinoma, Breast Cancer
Surprising progress has been made in the
biology of breast cancer in recent years. Breast cancer is
the commonest cancer in women worldwide. In India it is
the second most common female malignancy , accounting
28% of all malignancies in women. The age standardized
rate is 54.9 per 1,00,000 per year. Biomarkers expression
in breast cancer is used as a prognostic indicator and
predictor of response to hormonal and chemotherapy.
To date, the leading parameters that guide therapy in
breast cancer are estrogen receptor (ER), progesterone
receptor (PR) and human epidermal growth factor
(HER2neu). In recent years, gene expression analysis
studies have demonstrated the vitality of proliferation
signatures not only in the prognosis of breast cancer but
also as a predictive response to subsequent therapy
,(3,4,5 ). The aim of the current study is to analyse the
correlation between various pathological prognostic
markers of Invasive ductal carcinoma (IDC) of the
breast with Ki67 index and provide a rough estimate of
the cut-off values for the latter. The methodology used is
formalin fixed paraffin embedded tissue blocks and
slides (H&E histology and Immunohistochemistry) were
retrieved and reviewed. Re-cutting and re-staining of
faded material were carried out when needed. This is a
two-year study from February 2015 to February 2017.
Data were analysed using “SPSS Version 23.” The
outcomes of biomarker analysis showed that
immunohistochemical expression of Ki67 appears to be
associated with absence of ER, PR expression and
Her2neu positivity. These findings underlined the
relationship between Ki67, a relatively new biological
marker which is a valuable predictive factor in invasive
ductal carcinomas of breast. index” and the (p =0.04),
PR and Ki 67 (p=0.026). A slightly higher incidence of
Her-2/neu positivity was seen, and there was a significant
connection between “HER2-Neu” and “Ki-67” index and
the (p =0.029). The molecular groups and Ki67 have no
discernible relationship.
Keywords :
Ki-67, Prognostic Markers, Invasive Ductal Carcinoma, Breast Cancer
