Authors :
Smit Thacker; Ravirajsinh Vaghela
Volume/Issue :
Volume 11 - 2026, Issue 5 - May
Google Scholar :
https://tinyurl.com/2pf3vc8s
Scribd :
https://tinyurl.com/ywzbapuu
DOI :
https://doi.org/10.38124/ijisrt/26May250
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Chronic Kidney Disease (CKD) often progresses silently until advanced stages, making early detection crucial for
timely intervention. This paper introduces KTransNet, a novel hybrid deep learning model that combines Transformerbased encoders with CNN layers and integrates a YOLOv8 detection head for efficient early-stage CKD diagnosis from
medical imaging. The model employs a patch-based token embedding strategy with custom positional encoding and dense
blocks for feature reuse, enabling robust local and global feature extraction.
Keywords :
Chronic Kidney Disease CKD, Medical Imaging, Transformer-CNN Hybrid, Attention Mechanisms.
References :
- Bikbov, B., Purcell, C.A., Levey, A.S., Smith, M., Abdoli, A., Abebe, M., Ade- bayo, O.M., Afarideh, M., Agarwal, S.K., Agudelo-Botero, M., et al.: Global, regional, and national burden of chronic kidney disease, 1990–2017: a system- atic analysis for the global burden of disease study 2017. The lancet 395(10225), 709–733 (2020)
- Kalantar-Zadeh, K., Jafar, T.H., Nitsch, D., Neuen, B.L., Perkovic, V.: Chronic kidney disease. The lancet 398(10302), 786–802 (2021)
- Levin, A., Stevens, P.E., Bilous, R.W., Coresh, J., De Francisco, A.L., De Jong, P.E., Griffith, K.E., Hemmelgarn, B.R., Iseki, K., Lamb, E.J., et al.: Kidney disease: Improving global outcomes (kdigo) ckd work group. kdigo 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney international supplements 3(1), 1–150 (2013)
- Cockcroft, D.W., Gault, H.: Prediction of creatinine clearance from serum creatinine. Nephron 16(1), 31–41 (1976)
- Levey, A.S., Coresh, J.: Chronic kidney disease. The lancet 379(9811), 165–180 (2012)
- Litjens, G., Kooi, T., Bejnordi, B.E., Setio, A.A.A., Ciompi, F., Ghafoorian, M., Van Der Laak, J.A., Van Ginneken, B., S´anchez, C.I.: A survey on deep learning in medical image analysis. Medical image analysis 42, 60–88 (2017)
- Dosovitskiy, A., Beyer, L., Kolesnikov, A., Weissenborn, D., Zhai, X., Unterthiner, T., Dehghani, M., Minderer, M., Heigold, G., Gelly, S., et al.: An image is worth 16x16 words: Transformers for image recognition at scale. arXiv preprint arXiv:2010.11929 (2020)
- Liu, Y., Chen, P.-H.C., Krause, J., Peng, L.: How to read articles that use machine learning: users’ guides to the medical literature. Jama 322(18), 1806–1816 (2019)
- Zhou, Z., Siddiquee, M.M.R., Tajbakhsh, N., Liang, J.: Unet++: Redesigning skip connections to exploit multiscale features in image segmentation. IEEE transactions on medical imaging 39(6), 1856–1867 (2019)
- Habib, M., Aljarah, I., Faris, H., Mirjalili, S.: Multi-objective particle swarm optimization: theory, literature review, and application in feature selection for medical diagnosis. Evolutionary Machine Learning Techniques: Algorithms and Applications, 175–201 (2020)
- Nallarasan, V., Ponnusamy, V., Lakshminarayanan, R., Vigneshwari, S., Vinoth, R., et al.: Prediction of kidney disease utilizing a hybrid deep learning method- ology. In: 2024 2nd International Conference on Computer, Communication and Control (IC4), pp. 1–8 (2024). IEEE
- Asif, S., Awais, M., Khan, S.U.R.: Ir-cnn: Inception residual network for detect- ing kidney abnormalities from ct images. Network Modeling Analysis in Health Informatics and Bioinformatics 12(1), 35 (2023)
- He, K., Gan, C., Li, Z., Rekik, I., Yin, Z., Ji, W., Gao, Y., Wang, Q., Zhang, J., Shen, D.: Transformers in medical image analysis. Intelligent Medicine 3(1), 59–78 (2023)
- Islam, M.N., Al Mamun, M., Faruk, M.F., Srizon, A.Y., Hasan, S.M., Roy, B.: Spatial attention-guided deep learning for accurate kidney disease classification in ct scans. In: 2023 26th International Conference on Computer and Information Technology (ICCIT), pp. 1–6 (2023). IEEE
- Gogoi, P., Valan, J.A.: Interpretable machine learning for chronic kidney disease prediction: A shap and genetic algorithm-based approach. Biomedical Materials & Devices, 1–19 (2024)
- Kumar, S., Shastri, S., Mahajan, S., Singh, K., Gupta, S., Rani, R., Mohan, N., Mansotra, V.: Litecovidnet: A lightweight deep neural network model for detec- tion of covid-19 using x-ray images. International Journal of Imaging Systems and Technology 32(5), 1464–1480 (2022)
- Liu, J., Yildirim, O., Akin, O., Tian, Y.: Ai-driven robust kidney and renal mass segmentation and classification on 3d ct images. Bioengineering 10(1), 116 (2023)
- Xuan, P., Cui, H., Zhang, H., Zhang, T., Wang, L., Nakaguchi, T., Duh, H.B.: Dynamic graph convolutional autoencoder with node-attribute-wise attention for kidney and tumor segmentation from ct volumes. Knowledge-Based Systems 236, 107360 (2022)
- Yang, C., Guo, X., Chen, Z., Yuan, Y.: Source free domain adaptation for medical image segmentation with fourier style mining. Medical Image Analysis 79, 102457 (2022)
- Kolukisa, B., Bakir-Gungor, B.: Ensemble feature selection and classification methods for machine learning-based coronary artery disease diagnosis. Computer Standards & Interfaces 84, 103706 (2023)
- Zhou, H., Liu, Z., Li, T., Chen, Y., Huang, W., Zhang, Z.: Classification of pre- cancerous lesions based on fusion of multiple hierarchical features. Computer methods and programs in biomedicine 229, 107301 (2023)
- Alabi, R.O., Almangush, A., Elmusrati, M., M¨akitie, A.A.: Deep machine learning for oral cancer: from precise diagnosis to precision medicine. Frontiers in Oral Health 2, 794248 (2022)
- Jiang, H., Diao, Z., Shi, T., Zhou, Y., Wang, F., Hu, W., Zhu, X., Luo, S., Tong, G., Yao, Y.-D.: A review of deep learning-based multiple-lesion recognition from medical images: classification, detection and segmentation. Computers in Biology and Medicine 157, 106726 (2023)
- Wang, X., Li, Z., Huang, Y., Jiao, Y.: Multimodal medical image segmentation using multi-scale context-aware network. Neurocomputing 486, 135–146 (2022)
- Li, X., Li, M., Yan, P., Li, G., Jiang, Y., Luo, H., Yin, S.: Deep learning attention mechanism in medical image analysis: Basics and beyonds. International Journal of Network Dynamics and Intelligence, 93–116 (2023)
- Cheng, Z., Qu, A., He, X.: Contour-aware semantic segmentation network with spatial attention mechanism for medical image. The Visual Computer 38(3), 749– 762 (2022)
- Yan, K., Li, T., Marques, J.A.L., Gao, J., Fong, S.J.: A review on multimodal machine learning in medical diagnostics. Math. Biosci. Eng 20(5), 8708–8726 (2023)
- Kan, C., Ye, Z., Zhou, H., Cheruku, S.R.: Dg-ecg: Multi-stream deep graph learning for the recognition of disease-altered patterns in electrocardiogram. Biomedical Signal Processing and Control 80, 104388 (2023)
- Xu, L., Tang, Q., Zheng, B., Lv, J., Li, W., Zeng, X.: Cgftrans: Cross-modal global feature fusion transformer for medical report generation. IEEE Journal of Biomedical and Health Informatics (2024)
- Lin, F., Wang, Z., Zhao, H., Qiu, S., Shi, X., Wu, L., Gravina, R., Fortino, G.: Adaptive multi-modal fusion framework for activity monitoring of people with mobility disability. IEEE Journal of Biomedical and Health Informatics 26(8), 4314–4324 (2022)
- Liu, Y., Zhou, S., Wu, H., Han, W., Li, C., Chen, H.: Joint optimization of autoen- coder and self-supervised classifier: Anomaly detection of strawberries using hyperspectral imaging. Computers and Electronics in Agriculture 198, 107007 (2022)
- Thilakarathne, N.N., Muneeswari, G., Parthasarathy, V., Alassery, F., Hamam, H., Mahendran, R.K., Shafiq, M.: Federated learning for privacy-preserved medical internet of things. Intell. Autom. Soft Comput 33(1), 157–172 (2022)
- Alghamdi, W., Salama, R., Sirija, M., Abbas, A.R., Dilnoza, K.: Secure multi- party computation for collaborative data analysis. In: E3S Web of Conferences, vol. 399, p. 04034 (2023). EDP Sciences
- Khalid, N., Qayyum, A., Bilal, M., Al-Fuqaha, A., Qadir, J.: Privacy-preserving artificial intelligence in healthcare: Techniques and applications. Computers in Biology and Medicine 158, 106848 (2023)
- Goriparthi, R.G.: Interpretable machine learning models for healthcare diag- nostics: Addressing the black-box problem. Revista de Inteligencia Artificial en Medicina 13(1), 508–534 (2022)
- Zhang, Y., Weng, Y., Lund, J.: Applications of explainable artificial intelligence in diagnosis and surgery. Diagnostics 12(2), 237 (2022)
- Pillai, V.: Enhancing transparency and understanding in ai decision-making processes. Iconic Research and Engineering Journals 8(1), 168–172 (2024)
- Gligorea, I., Cioca, M., Oancea, R., Gorski, A.-T., Gorski, H., Tudorache, P.: Adaptive learning using artificial intelligence in e-learning: a literature review. Education Sciences 13(12), 1216 (2023)
- Jenkins, D.A., Sperrin, M., Martin, G.P., Peek, N.: Dynamic models to predict health outcomes: current status and methodological challenges. Diagnostic and prognostic research 2, 1–9 (2018)
- Gonz´alez, C., Ranem, A., Santos, D., Othman, A., Mukhopadhyay, A.: Life- long nnu-net: a framework for standardized medical continual learning. Scientific Reports 13(1), 9381 (2023)
- Sathianathen, N.J., Heller, N., Tejpaul, R., Stai, B., Kalapara, A., Rickman, J., Dean, J., Oestreich, M., Blake, P., Kaluzniak, H., et al.: Automatic segmentation of kidneys and kidney tumors: the kits19 international challenge. Frontiers in Digital Health 3, 797607 (2022)
- Keshwani, D., Kitamura, Y., Li, Y.: Computation of total kidney volume from ct images in autosomal dominant polycystic kidney disease using multi-task 3d convolutional neural networks. In: Machine Learning in Medical Imaging: 9th International Workshop, MLMI 2018, Held in Conjunction with MICCAI 2018,
- Granada, Spain, September 16, 2018, Proceedings 9, pp. 380–388 (2018). Springer
- Zhang, W., Blumenfeld, J.D., Prince, M.R.: Mri in autosomal dominant polycystic kidney disease. Journal of Magnetic Resonance Imaging 50(1), 41–51 (2019)
- Hu, J., Zhong, X., Yan, J., Zhou, D., Qin, D., Xiao, X., Zheng, Y., Liu, Y.: High-throughput sequencing analysis of intestinal flora changes in esrd and ckd patients. BMC nephrology 21, 1–11 (2020)
- Ragab, M.G., Abdulkader, S.J., Muneer, A., Alqushaibi, A., Sumiea, E.H., Qureshi, R., Al-Selwi, S.M., Alhussian, H.: A comprehensive systematic review of yolo for medical object detection (2018 to 2023). IEEE Access (2024)
- Billah, M., Al Rakib, A., Haque, M., Ahamed, A., Hossain, M.: S., borsha kn (2024) real-time object detection in medical imaging using yolo models for kid- ney stone detection. European Journal of Computer Science and Information Technology 12(7), 54–65
- Wang, J., Wu, M., Guo, Y., Wu, H., Wan, Z.: Evaluating fairness of mask r- cnn for kidney infection detection based on renal scintigraphy. In: 2024 IEEE International Conference on Big Data (BigData), pp. 4637–4642 (2024). IEEE
Chronic Kidney Disease (CKD) often progresses silently until advanced stages, making early detection crucial for
timely intervention. This paper introduces KTransNet, a novel hybrid deep learning model that combines Transformerbased encoders with CNN layers and integrates a YOLOv8 detection head for efficient early-stage CKD diagnosis from
medical imaging. The model employs a patch-based token embedding strategy with custom positional encoding and dense
blocks for feature reuse, enabling robust local and global feature extraction.
Keywords :
Chronic Kidney Disease CKD, Medical Imaging, Transformer-CNN Hybrid, Attention Mechanisms.