Authors :
Robin Sharma; Roshmi Ray; Anupama Kumari
Volume/Issue :
Volume 7 - 2022, Issue 9 - September
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3BYdZOY
DOI :
https://doi.org/10.5281/zenodo.7127272
Abstract :
Millions of people throughout the world are
affected by Parkinson disease (PD), which is a prevalent
neurological ailment. The illness is now understood to be
heterogeneous and to manifest both motor and nonmotor symptoms. The latest study reveals that men are
more likely than women to develop Parkinson's disease
and that the number of people with the diagnosis rises
with age regardless of sex. There have been significant
improvements in PD pathophysiology, etiology, and
treatment. Depending on the progression and stage of
the disease, many surgical techniques are available that
can improve the condition of PD patients This article
offers a summary of our current knowledge on
Parkinson's disease (PD), including its pathology,
genesis, recent developments, clinical research review,
and case studies of patients to assess how treatments and
drugs affect them. Latest translation studies are aimed
into understanding the disease pathogenesis and
pathophysiology and in many areas translational
research on this has catalysed a better understanding of
basic biological phenomena including intrinsically
disordered proteins autophagy mitochondrial function
homeostatic plasticity and basal ganglia physiology. This
review focuses on compiling all the fundamental data
and therapies available in medical research for the relief
of symptoms and suggested therapies proven successful
in PD. We also provided an overview of Parkinson's
clinical trials and the effects of Parkinson medication in
animal models. The most recent developments and
trends in PD were also covered, including information on
biomarkers, sexual differences, cell therapy, genetic
relationships, and improvements in PD study models.
Keywords :
Parkinson’s disease, Cognitive behavioural therapy, deep brain stimulation, chemotherapy, patient counselling.
Millions of people throughout the world are
affected by Parkinson disease (PD), which is a prevalent
neurological ailment. The illness is now understood to be
heterogeneous and to manifest both motor and nonmotor symptoms. The latest study reveals that men are
more likely than women to develop Parkinson's disease
and that the number of people with the diagnosis rises
with age regardless of sex. There have been significant
improvements in PD pathophysiology, etiology, and
treatment. Depending on the progression and stage of
the disease, many surgical techniques are available that
can improve the condition of PD patients This article
offers a summary of our current knowledge on
Parkinson's disease (PD), including its pathology,
genesis, recent developments, clinical research review,
and case studies of patients to assess how treatments and
drugs affect them. Latest translation studies are aimed
into understanding the disease pathogenesis and
pathophysiology and in many areas translational
research on this has catalysed a better understanding of
basic biological phenomena including intrinsically
disordered proteins autophagy mitochondrial function
homeostatic plasticity and basal ganglia physiology. This
review focuses on compiling all the fundamental data
and therapies available in medical research for the relief
of symptoms and suggested therapies proven successful
in PD. We also provided an overview of Parkinson's
clinical trials and the effects of Parkinson medication in
animal models. The most recent developments and
trends in PD were also covered, including information on
biomarkers, sexual differences, cell therapy, genetic
relationships, and improvements in PD study models.
Keywords :
Parkinson’s disease, Cognitive behavioural therapy, deep brain stimulation, chemotherapy, patient counselling.
