Authors :
Christianus Rustin
Volume/Issue :
Volume 7 - 2022, Issue 7 - July
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3Kc2FCF
DOI :
https://doi.org/10.5281/zenodo.6996003
Abstract :
Hypercholesterolemia is a medical condition
associated with the unbalance in lipids level due to
unhealthy diets and potentially leading to various heartrelated diseases if remains untreated. This study focused
on lipid profiling in Sprague Dawley (SD) rats to provide
more insight in future research in prognosis and
treatment of cardiovascular diseases. There were 15 male
Sprague Dawley (SD) rats maintained in an animal house
and fed with HFD (n=10) and Normal Diet (n=5). Lipid
profiling within four different timelines was conducted
using 3-in-1 combo test device for a complete lipid panel
(Mission cholesterol meter) and Multi-Linear Regression
(MLR) analysis performed using SPSS software. The
obvious effects of High Fat Diet (HFD) shown in the
unbalanced fluctuation of lipids level in SD rats from day
0 to day 90. According to MLR, the average mean of
Low-Density Lipoprotein (LDL) and High-Density
Lipoprotein (HDL) were in an increasing and decreasing
patterns respectively. Meanwhile, triglyceride (TG) and
total cholesterol (TC) were in an increasing and
decreasing patterns respectively and each lipid in HFD
were statistically correlated and significant. Unlike the
control group, lipids level appeared to be in a constant
manner. Our finding concluded that, dietary played a
crucial role in the abnormality of lipid level which
subsequently contributed to the occurrence of heart
diseases
Keywords :
Cardiovascular, High-Fat Diet (HFD), Lipid, Sprague Dawley (SD).
Hypercholesterolemia is a medical condition
associated with the unbalance in lipids level due to
unhealthy diets and potentially leading to various heartrelated diseases if remains untreated. This study focused
on lipid profiling in Sprague Dawley (SD) rats to provide
more insight in future research in prognosis and
treatment of cardiovascular diseases. There were 15 male
Sprague Dawley (SD) rats maintained in an animal house
and fed with HFD (n=10) and Normal Diet (n=5). Lipid
profiling within four different timelines was conducted
using 3-in-1 combo test device for a complete lipid panel
(Mission cholesterol meter) and Multi-Linear Regression
(MLR) analysis performed using SPSS software. The
obvious effects of High Fat Diet (HFD) shown in the
unbalanced fluctuation of lipids level in SD rats from day
0 to day 90. According to MLR, the average mean of
Low-Density Lipoprotein (LDL) and High-Density
Lipoprotein (HDL) were in an increasing and decreasing
patterns respectively. Meanwhile, triglyceride (TG) and
total cholesterol (TC) were in an increasing and
decreasing patterns respectively and each lipid in HFD
were statistically correlated and significant. Unlike the
control group, lipids level appeared to be in a constant
manner. Our finding concluded that, dietary played a
crucial role in the abnormality of lipid level which
subsequently contributed to the occurrence of heart
diseases
Keywords :
Cardiovascular, High-Fat Diet (HFD), Lipid, Sprague Dawley (SD).
