Authors : Jaspreet Singh; Amandeep Singh

Volume/Issue : Volume 9 - 2024, Issue 8 - August

---

Google Scholar : https://tinyurl.com/5b7c57mh

Scribd : https://tinyurl.com/3586bt38

DOI : https://doi.org/10.38124/ijisrt/IJISRT24AUG1418

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

---

Abstract : Lunasin is a natural peptide of plant origin possessing potential activity against chronic disorders specially cancer along with associated cardiovascular diseases. The bioavailability and confirmed effectiveness against breast, skin and colorectal cancer has declared lunasin as a promising chemo-preventive agent. Lunasin, a 43 amino acids long peptide possess anti-inflammatory and anti-oxidative activity. Modern biotechnological techniques viz. genomics, proteomics along with other biochemical tools are continuously elucidating the molecular mechanisms of lunacin action. Lunasin enriched natural product-based healthcare remedies for the prevention of life style induced cancer is suggested as an alternative to the conventional chemo, immuno and hormonal therapy.

Keywords : Lunasin, Chemo-Preventive, Soybean Peptide, Cancer, Anti-Inflammatory, Anti-Oxidant, Nutraceutical, Proliferation, Differentiation.

References :

1. Balasubramanyam, K., Swaminathan, V., Ranganathan, A., & Kundu, T. K. (2003). Small molecule modulators of histone acetyltransferase p300. Journal of Biological Chemistry, 278(21), 19134-19140.
2. Béliveau, R., & Gingras, D. (2007). Role of nutrition in preventing cancer. Canadian Family Physician, 53(11), 1905-1911.
3. Bhutia, S. K., & Maiti, T. K. (2008). Targeting tumors with peptides from natural sources. Trends in biotechnology, 26(4), 210-217.
4. Cavazos A, Morales E, Dia V. P. & de Mejia EG (2012). Analysis of lunasin in commercial and pilot plant produced soybean products and an improved method of lunasin purification. Journal of Food Science, 77:C539-545.
5. de Mejia, E. G. & Dia, V. P. (2010). The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells. Cancer and Metastasis Reviews, 29, 511-528.
6. de Mejia, E. G. & Dia, V. P. (2009). Lunasin and lunasin-like peptides inhibit inflammation through suppression of NF-kB pathway in the macrophage. Peptides, 30, 2388-2398.
7. de Mejia, E. G., Vasconez, M., de Lumen, B. O. & Nelson, R. (2004).  Lunasin concentration in different soybean genotypes, commercial soy protein, and isoflavone products. Journal of Agricultural and Food Chemistry, 52, 5882-5887.
8. Dia, V. P., Frankland-Searby, S., Del Hierro, F. L., Garcia, G., & De Mejia, E. G. (2013). Structural property of soybean lunasin and development of a method to quantify lunasin in plasma using an optimized immunoassay protocol. Food chemistry, 138(1), 334-341.
9. Dia, V. P., Torres, S., De Lumen, B. O., Erdman Jr, J. W., & Gonzalez De Mejia, E. (2009). Presence of lunasin in plasma of men after soy protein consumption. Journal of Agricultural and Food Chemistry, 57(4), 1260-1266.
10. Dia, V. P., & De Mejia, E. G. (2011). Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells. Molecular nutrition & food research, 55(4), 623-634.
11. FDA Talk Paper, United States Department of Health and Human Services. 1999, October 26. Washington, DC: United States Government Printing Office.
12. Fimognari, C., Lenzi, M., & Hrelia, P. (2008). Chemoprevention of cancer by isothiocyanates and anthocyanins: mechanisms of action and structure-activity relationship. Current medicinal chemistry, 15(5), 440-447.
13. Galvez, A. F., Chen, N., Macasieb, J., & de Lumen, B. O. (2001). Chemo-preventive property of a soybean peptide (lunasin) that binds to deacetylated histones and inhibits acetylation. Cancer research, 61(20), 7473-7478.
14. Galvez, A. F., & De Lumen, B. O. (1999). A soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells. Nature biotechnology, 17(5), 495-500.
15. Galvez, A. F., Revilleza, M. J. R., & de Lumen, B. O. (1997). A novel methionine-rich protein from soybean cotyledon: cloning and characterization of cDNA (accession No. AF005030). Plant Register# PGR97-103. Plant Physiology, 114, 1567-1569.
16. Garcia, M., Jemal, A., Ward, E. M. et al. 2007. Global Cancer Facts & Figures 2007. Atlanta, GA: The American Cancer Society.
17. Gonzalez de Mejia, E., Vásconez, M., de Lumen, B. O., & Nelson, R. (2004). Lunasin concentration in different soybean genotypes, commercial soy protein, and isoflavone products. Journal of agricultural and food chemistry, 52(19), 5882-5887.
18. Goodman, M.T., Wilkens, L.R., Hankin, J.H. et al. 1997. Association of soy and fiber consumption with the risk of endometrial cancer. Am. J. Epidemiol., 146:294–306.
19. Helt, A.M. and Galloway, D.A. 2003. Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins. Carcinogenesis 24: 159–169.
20. Hernandez-Ledesmaa, B., Hsiehb, C. C., & de Lumenb, B. O. (2013). Lunasin, a seed peptide with promising cancer preventive properties. Protein & Peptide Letters, 20(4) 424-432.
21. Hernández‐Ledesma, B., Hsieh, C. C., & de Lumen, B. O. (2011). Relationship between lunasin's sequence and its inhibitory activity of histones H3 and H4 acetylation. Molecular nutrition & food research, 55(7), 989-998.
22. Hernández-Ledesma, B.; Hsieh, C. C. & de Lumen, B.O. (2009) Antiinflammatory and antioxidant properties of peptide lunasin in RAW 264.7 macrophages. Biochemical and Biophysical Research Communications, 390, 803-808.
23. Hernández-Ledesma, B., & De Lumen, B. O. (2008). Lunasin: a novel cancer preventive seed peptide. Perspectives in medicinal chemistry, 2, PMC-S372.
24. Hsieh, C. C., Hernández-Ledesma, B., Jeong, H. J., Park, J. H., & de Lumen, B. O. (2010a). Complementary roles in cancer prevention: protease inhibitor makes the cancer preventive peptide lunasin bioavailable. PloS one, 5(1), e8890.
25. Hsieh, C. C., Hernández‐Ledesma, B., & De Lumen, B. O. (2010b). Soybean peptide lunasin suppresses in vitro and in vivo 7, 12‐dimethylbenz [a] anthracene‐induced tumorigenesis. Journal of Food Science, 75(9), H311-H316.
26. Hsieh, C. C., Martínez‐Villaluenga, C., de Lumen, B. O., & Hernández‐Ledesma, B. (2018). Updating the research on the chemopreventive and therapeutic role of the peptide lunasin. Journal of the Science of Food and Agriculture, 98(6), 2070-2079.
27. Hsieh, C. C., Hernández-Ledesma, B., & de Lumen, B. O. (2011a). Lunasin: A novel seed peptide with cancer preventive properties. In Bioactive Food Proteins and Peptides: Applications in Human Health (pp. 293-311). CRC Press.
28. Hsieh, C. C., Hernández-Ledesma, B., & de Lumen, B. O. (2011b). Lunasin–aspirin combination against NIH/3T3 cells transformation induced by chemical carcinogens. Plant foods for human nutrition, 66, 107-113.
29. Jeong, J.B.; de Lumen, B.O.; Jeong, H.J. (2010) Lunasin peptide purified from Solanum nigrum L. protects DNA from oxidative damage by suppressing the generation of hydroxyl radical via blocking fenton reaction. Cancer Letters, 293, 58-64.
30. Jeong, J. B., Jeong, H. J., Park, J. H., Lee, S. H., Lee, J. R., Lee, H. K., ... & De Lumen, B. O. (2007a). Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb). Journal of agricultural and food chemistry, 55(26), 10707-10713.
31. Jeong, H. J., Jeong, J. B., Kim, D. S., & de Lumen, B. O. (2007b). Inhibition of core histone acetylation by the cancer preventive peptide lunasin. Journal of agricultural and food chemistry, 55(3), 632-637.
32. Lam, Y., Galvez, A., & de Lumen, B. O. (2003). Lunasin™ suppresses E1A-mediated transformation of mammalian cells but does not inhibit growth of immortalized and established cancer cell lines. Nutrition and cancer, 47(1), 88-94.
33. Lee, M. M., Gomez, S. L., Chang, J. S., Wey, M., Wang, R. T., & Hsing, A. W. (2003). Soy and isoflavone consumption in relation to prostate cancer risk in China. Cancer Epidemiology Biomarkers & Prevention, 12(7), 665-668.
34. Liu, J., Jia, S. H., Kirberger, M., & Chen, N. (2014). Lunasin as a promising health-beneficial peptide. European Review for Medical & Pharmacological Sciences, 18(14) 2070-2075
35. Manson, M. M. (2003). Cancer prevention–the potential for diet to modulate molecular signalling. Trends in molecular medicine, 9(1), 11-18.
36. McCue, P., & Shetty, K. (2004). Health benefits of soy isoflavonoids and strategies for enhancement: a review. Critical reviews in food science and nutrition, 44(5), 361-367.
37. Seber, L. E., Barnett, B. W., McConnell, E. J., Hume, S. D., Cai, J., Boles, K., & Davis, K. R. (2012). Scalable purification and characterization of the anticancer lunasin peptide from soybean. PloS one, 7(4), e35409.
38. Singh, P., & Bisetty, K. (2012). A molecular dynamics study of lunasin. South African Journal of Chemistry, 65, 115-124.
39. Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A cancer journal for clinicians, 71(3), 209-249.
40. Van Breda, S. G., de Kok, T. M., & van Delft, J. H. (2008). Mechanisms of colorectal and lung cancer prevention by vegetables: a genomic approach. The Journal of nutritional biochemistry, 19(3), 139-157.
41. Yamamoto, S., Sobue, T., Kobayashi, M., Sasaki, S., & Tsugane, S. (2003). Soy, isoflavones, and breast cancer risk in Japan. Journal of the national cancer institute, 95(12), 906-913.