Authors :
Lawal Olayinka Olusegun; Alowolodu Olufunso Dayo; Obe Olumide Olayinka; Adetunmbi Adebayo Olusola
Volume/Issue :
Volume 11 - 2026, Issue 4 - April
Google Scholar :
https://tinyurl.com/42z5vb6s
Scribd :
https://tinyurl.com/jb8n678a
DOI :
https://doi.org/10.38124/ijisrt/26apr1555
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Cardiovascular diseases (CVDs) contribute significantly to global health challenges, demanding prompt early
detection and intervention to reduce harmful outcomes. The application of machine learning (ML) techniques offers a viable
avenue to revolutionise conventional diagnostic methods in CVD detection. This review examined the ML algorithms for
risk prediction and diagnosis of various CVDs, including arrhythmias, heart failure (HF), and coronary artery disease
(CAD), emphasising diverse approaches, challenges, and avenues for future research. Machine learning models utilise
complex patterns found within extensive Clinical datasets encompassing electronic health records (EHRs) and diagnostic
imaging to improve early diagnosis and individualised treatment management strategies for affected individuals at risk for
CVD diseases. This study defines open research problems requiring further investigation to enhance the efficacy and clinical
applicability of ML models in combating cardiovascular diseases. This work recommends reliable and interpretable ML
models, integration of heterogeneous data sources, collaborative efforts to address data scarcity, and advancements in model
transparency and explainability. The integration of ML techniques holds great promise for advancing CVD detection and
improving patient outcomes. Overcoming the challenges outlined in this review and examining opportunities for future study
can unlock the full potential of ML in alleviating the global burden of CVD-related morbidity and mortality.
Keywords :
Machine Learning, Cardiovascular Disease Detection, Risk Prediction, Diagnosis, Challenges, Open Research Problems.
References :
- Aggarwal, R., Sounderajah, V., Martin, G., Ting, D. S. W., Karthikesalingam, A., King, D., Ashrafian, H., & Darzi, A. (2021). Diagnostic accuracy of deep learning in medical imaging: a systematic review and meta-analysis. Npj Digital Medicine, 4(1). https://doi.org/10.1038/s41746-021-00438-z
- Al-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., Gillis, A. M., Granger, C. B., Hammill, S. C., Hlatky, M. A., Joglar, J. A., Kay, G. N., Matlock, D. D., Myerburg, R. J., & Page, R. L. (2018). 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Hea. Journal of the American College of Cardiology, 72(14), e91–e220. https://doi.org/10.1016/j.jacc.2017.10.054
- Alkalah, C. (2016). 済無No Title No Title No Title. High-Performance Medicine: The Convergence of Human and Artificial Intelligence. Nature Medicine, 19(5), 1–23.
- Alzubaidi, L., Bai, J., Al-Sabaawi, A., Santamaría, J., Albahri, A. S., Al-dabbagh, B. S. N., Fadhel, M. A., Manoufali, M., Zhang, J., Al-Timemy, A. H., Duan, Y., Abdullah, A., Farhan, L., Lu, Y., Gupta, A., Albu, F., Abbosh, A., & Gu, Y. (2023). A survey on deep learning tools dealing with data scarcity: definitions, challenges, solutions, tips, and applications. Journal of Big Data, 10(1). https://doi.org/10.1186/s40537-023-00727-2
- Anderson, J., & Brown, R. (2020). Supervised learning methods for cardiovascular risk prediction. Journal of Cardiovascular Research, 32(4), 123–134.
- Chen, I. Y., Pierson, E., Rose, S., Joshi, S., Ferryman, K., & Ghassemi, M. (2021). Ethical Machine Learning in Healthcare. Annual Review of Biomedical Data Science, 4, 123–144. https://doi.org/10.1146/annurev-biodatasci-092820-114757
- Choi, E., Schuetz, A., Stewart, W. F., & Sun, J. (2017). Using recurrent neural network models for early detection of heart failure onset. Journal of the American Medical Informatics Association, 24(2), 361–370. https://doi.org/10.1093/jamia/ocw112
- Colizzi, M., Lasalvia, A., & Ruggeri, M. (2020). Prevention and early intervention in youth mental health: Is it time for a multidisciplinary and trans-diagnostic model for care? International Journal of Mental Health Systems, 14(1), 1–14. https://doi.org/10.1186/s13033-020-00356-9
- De Zarzà, I., de Curtò, J., Hernández-Orallo, E., & Calafate, C. T. (2023). Cascading and Ensemble Techniques in Deep Learning. Electronics (Switzerland), 12(15), 1–18. https://doi.org/10.3390/electronics12153354
- Doe, A., Smith, L., & Nguyen, T. (2019). Advanced machine learning techniques in heart disease detection. IEEE Transactions on Biomedical Engineering, 62(2), 678–690.
- Domdouzis, K., Lake, P., Crowther, P. (2021). Graph Databases. In the Concise Guide to Databases. SpringerBriefs in Applied Sciences and Technology, 223–235.
- Frasca, M., La Torre, D., Pravettoni, G., & Cutica, I. (2024). Explainable and interpretable artificial intelligence in medicine: a systematic bibliometric review. Discover Artificial Intelligence, 4(1). https://doi.org/10.1007/s44163-024-00114-7
- García-Ordás, M. T., Bayón-Gutiérrez, M., Benavides, C., Aveleira-Mata, J., & Benítez-Andrades, J. A. (2023). Heart disease risk prediction using deep learning techniques with feature augmentation. Multimedia Tools and Applications, 82(20), 31759–31773. https://doi.org/10.1007/s11042-023-14817-z
- Houyel, L., & Meilhac, S. M. (2021). Heart Development and Congenital Structural Heart Defects. 257–284.
- Keller, K. (2014). National Heart, Lung, and Blood Institute. Encyclopedia of Obesity. https://doi.org/10.4135/9781412963862.n312
- Khan, M., & Zhao, Y. (2021). Clustering algorithms for analysing cardiovascular disease datasets. International Journal of Data Science, 5(1), 32–45.
- Krittanawong, C., Virk, H. U. H., Bangalore, S., Wang, Z., Johnson, K. W., Pinotti, R., Zhang, H. J., Kaplin, S., Narasimhan, B., Kitai, T., Baber, U., Halperin, J. L., & Tang, W. H. W. (2020). Machine learning prediction in cardiovascular diseases: a meta-analysis. Scientific Reports, 10(1), 1–11. https://doi.org/10.1038/s41598-020-72685-1
- Li, H., Wang, X., Liu, C., Zeng, Q., Zheng, Y., Chu, X., Yao, L., Wang, J., Jiao, Y., & Karmakar, C. (2020). A fusion framework based on multi-domain features and deep learning features of the phonocardiogram for coronary artery disease detection. Computers in Biology and Medicine, 120(March), 103733. https://doi.org/10.1016/j.compbiomed.2020.103733
- Liesenborghs, L., & Vanassche, T. (2020). Coagulation : At the heart of infective endocarditis. Journal of Thrombosis and Haemostasis, 18(5), 995–1008. https://doi.org/10.1111/jth.14736
- Lo Piano, S. (2020). Ethical principles in machine learning and artificial intelligence: cases from the field and possible ways forward. Humanities and Social Sciences Communications, 7(1), 1–7. https://doi.org/10.1057/s41599-020-0501-9
- Loades, J. (2018). Understanding heart failure. Practice Nurse, 48(6), 25–30. https://doi.org/10.4172/2324-8602.1000296
- Mahmud, M., Kaiser, M. S., McGinnity, T. M., & Hussain, A. (2021). Deep Learning in Mining Biological Data. In Cognitive Computation (Vol. 13, Issue 1). Springer US. https://doi.org/10.1007/s12559-020-09773-x
- Obermeyer, Z., Powers, B., Vogeli, C., & Mullainathan, S. (2019). Dissecting racial bias in an algorithm used to manage the health of populations. Science, 366(6464), 447–453. https://doi.org/10.1126/science.aax2342
- Raji, R. A., Rashid, S., & Ishak, S. (2019). The mediating effect of brand image on the relationships between social media advertising content, sales promotion content and behavioural intention. Journal of Research in Interactive Marketing, 13(3), 302–330. https://doi.org/10.1108/JRIM-01-2018-0004
- Rangineni, S. (2023). An Analysis of Data Quality Requirements for Machine Learning Development Pipelines Frameworks. International Journal of Computer Trends and Technology, 71(8), 16–27. https://doi.org/10.14445/22312803/ijctt-v71i8p103
- Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009). Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the global burden of disease study 2016. The Lancet, 373(9682), 2223.
- Saxena, S., & Paul, S. (2020). Deep learning applications in medical imaging. Deep Learning Applications in Medical Imaging, 27(3), 1–274. https://doi.org/10.4018/978-1-7998-5071-7
- Selak, V., Poppe, K., Grey, C., Mehta, S., Winter-Smith, J., Jackson, R., Wells, S., Exeter, D., Kerr, A., Riddell, T., & Harwood, M. (2020). Ethnic differences in cardiovascular risk profiles among 475,241 adults in primary care in Aotearoa, New Zealand. New Zealand Medical Journal, 133(1521), 14–27.
- Shah, R. U., Steyerberg, E. W., Windecker, S., & Holzmann, M. J. (2020). Machine learning in cardiovascular disease prediction: algorithms and practices. Nature Reviews Cardiology. 17(6), 330–342.
- Shetty, P. (2010). Nutrition transition and its health outcomes. Indian Journal of Paediatrics, 77(3), 252–255.
- Siala, H., & Wang, Y. (2022). SHIFTing artificial intelligence to be responsible in healthcare: A systematic review. Social Science and Medicine, 296(June 2021), 114782. https://doi.org/10.1016/j.socscimed.2022.114782
- Ski, C. F., Cartledge, S., Foldager, D., Thompson, D. R., Fredericks, S., Ekman, I., & Hendriks, J. M. (2023). Integrated care in cardiovascular disease: a statement of the Association of Cardiovascular Nursing and Allied Professions of the European Society of Cardiology. European Journal of Cardiovascular Nursing, 22(5), E39–E46. https://doi.org/10.1093/eurjcn/zvad009
- Smith, J., Brown, L., & Green, T. (2021). Advanced machine learning models in healthcare: Current challenges and future directions. Health Information Science and Systems, 9(1), 47–55. https://doi.org/10.1007/s13755-021-00327-0
- Smith, P., Johnson, Q., & Lee, M. (2021). Machine learning approaches in predicting cardiovascular events. Circulation: Cardiovascular Quality and Outcomes, Https://Doi.Org/10.1161/CIRCOUTCOMES.120.007895, 14(6).
- Topol, E. J. (2019). High-performance medicine: the convergence of human and artificial intelligence. Nature Medicine, 25(1), 44–56. https://doi.org/10.1038/s41591-018-0300-7
- Wang, Y., Liu, L., & Wang, C. (2023). Trends in using deep learning algorithms in biomedical prediction systems. Frontiers in Neuroscience, 17(November), 1–32. https://doi.org/10.3389/fnins.2023.1256351
- WHO. (2021). Cardiovascular diseases (CVDs) key facts. World Health Organisation, June 1–5. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
- Wu, C. C., Yeh, W. C., Hsu, W. D., Islam, M. M., Nguyen, P. A. (Alex), Poly, T. N., Wang, Y. C., Yang, H. C., & (Jack) Li, Y. C. (2019). Prediction of fatty liver disease using machine learning algorithms. Computer Methods and Programs in Biomedicine, 170, 23–29. https://doi.org/10.1016/j.cmpb.2018.12.032
- Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Colvin, M. M., Drazner, M. H., Filippatos, G. S., Fonarow, G. C., Givertz, M. M., Hollenberg, S. M., Lindenfeld, J. A., Masoudi, F. A., McBride, P. E., Peterson, P. N., Stevenson, L. W., & Westlake, C. (2017). 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Journal of the American College of Cardiology, 70(6), 776–803. https://doi.org/10.1016/j.jacc.2017.04.025
- Yu, H., Yang, L. T., Zhang, Q., Armstrong, D., & Deen, M. J. (2021). Convolutional neural networks for medical image analysis: State-of-the-art, comparisons, improvement and perspectives. Neurocomputing, 444, 92–110. https://doi.org/10.1016/j.neucom.2020.04.157
- Zhang, A. P., Wang, G. X., Zhang, W., & Zhang, J. Y. (2023). Cardiovascular disease classification based on a multi-classification integrated model. Networks and Heterogeneous Media, 18(4), 1630–1656. https://doi.org/10.3934/nhm.2023071
Cardiovascular diseases (CVDs) contribute significantly to global health challenges, demanding prompt early
detection and intervention to reduce harmful outcomes. The application of machine learning (ML) techniques offers a viable
avenue to revolutionise conventional diagnostic methods in CVD detection. This review examined the ML algorithms for
risk prediction and diagnosis of various CVDs, including arrhythmias, heart failure (HF), and coronary artery disease
(CAD), emphasising diverse approaches, challenges, and avenues for future research. Machine learning models utilise
complex patterns found within extensive Clinical datasets encompassing electronic health records (EHRs) and diagnostic
imaging to improve early diagnosis and individualised treatment management strategies for affected individuals at risk for
CVD diseases. This study defines open research problems requiring further investigation to enhance the efficacy and clinical
applicability of ML models in combating cardiovascular diseases. This work recommends reliable and interpretable ML
models, integration of heterogeneous data sources, collaborative efforts to address data scarcity, and advancements in model
transparency and explainability. The integration of ML techniques holds great promise for advancing CVD detection and
improving patient outcomes. Overcoming the challenges outlined in this review and examining opportunities for future study
can unlock the full potential of ML in alleviating the global burden of CVD-related morbidity and mortality.
Keywords :
Machine Learning, Cardiovascular Disease Detection, Risk Prediction, Diagnosis, Challenges, Open Research Problems.