Authors :
M. Iosifidis; A. Moubasher
Volume/Issue :
Volume 10 - 2025, Issue 12 - December
Google Scholar :
https://tinyurl.com/5cx8p9c6
Scribd :
https://tinyurl.com/3hraj4u6
DOI :
https://doi.org/10.38124/ijisrt/25dec528
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
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Abstract :
Angiomyolipomas (AMLs) are uncommon, benign tumours of the kidney that can be sporadic or associated with
the Tuberous Sclerosis Complex (TSC). Individuals with AML can be asymptomatic, or present with life threatening
perirenal bleeding. An association with rapid growth during pregnancy, has been identified, thought to be resulting from
increased hormones antenatally. Having said that, existing literature lacks an established pathway in managing AML in
pregnancy. Databases including PubMed (MEDLINE) and Google Scholar were browsed until May 2025, using the below
keywords. The aim of this review article is to emphasise the importance of careful management of AML in pregnancy and
aid in establishing a clear pathway that will help in minimising risk to both mother and foetus.
Keywords :
Angiomyolipoma, Renal Angiomyolipoma, Kidney Tumour, Renal Tumour, Angiomyolipoma in Pregnancy, AML Management.
References :
- Lienert, A.R. and Nicol, D. (2012). Renal angiomyolipoma. BJU International, 110, pp.25–27. doi:https://doi.org/10.1111/j.1464-410x.2012.11618.x.
- MyPathologyReport. (2025). Your pathology report for angiomyolipoma (AML) | MyPathologyReport. [online] Available at: https://www.mypathologyreport.ca/diagnosis-library/angiomyolipoma-aml/ [Accessed 9 Dec. 2025].
- Labra, A., Schiappacasse, G., Constenla, D. and Cristi, J. (2025). Renal angiomyolipomas: Typical and atypical features on computed tomography and magnetic resonance imaging. World Journal of Radiology, 17(2). doi:https://doi.org/10.4329/wjr.v17.i2.104282.
- Fittschen A, Wendlik I, Oeztuerk S, Kratzer W, Akinli AS, Haenle MM, Graeter T. Prevalence of sporadic renal angiomyolipoma: a retrospective analysis of 61,389 in- and out-patients. Abdom Imaging. 2014;39:1009–1013. doi: 10.1007/s00261-014-0129-6.
- Nelson CP, Sanda MG. Contemporary diagnosis and management of renal angiomyolipoma. J Urol. 2002;168:1315–1325. doi: 10.1016/S0022-5347(05)64440-0.
- Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB. Update on the Diagnosis and Management of Renal Angiomyolipoma. J Urol. 2016;195:834–846. doi: 10.1016/j.juro.2015.07.126.
- Zapardiel, I., Jesús Delafuente-Valero and José Bajo-Arenas (2011). Renal Angiomyolipoma during Pregnancy: Review of the Literature. Gynecologic and Obstetric Investigation, 72(4), pp.217–219. doi:https://doi.org/10.1159/000329328.
- Cihan Çetin, Selim Büyükkurt, Demir, C. and Cüneyt Evrüke (2015). Renal angiomyolipoma during pregnancy: Case report and literature review. Türk jinekoloji ve obstetrik derneği dergisi, 12(2), pp.118–121. doi:https://doi.org/10.4274/tjod.32848.
- Dell’Atti, L. and Slyusar, V. (2025). Robotic Surgery in the Management of Renal Tumors During Pregnancy: A Narrative Review. Cancers, 17(4), p.574. doi:https://doi.org/10.3390/cancers17040574.
- Lane BR, Aydin H, Danforth TL, et al. Clinical correlates of renal angiomyolipoma subtypes in 209 patients: classic, fat poor, tuberous sclerosis associated and epithelioid.
J Urol 2008; 180: 836–843
- Bissler JJ, Kingswood JC. Renal angiomyolipomata. Kidney Int 2004;
66: 924–934
- Preece, P., Mees, B., Norris, B., Christie, M., Wagner, T. and Dundee, P. (2015). Surgical management of haemorrhaging renal angiomyolipoma in pregnancy. International journal of surgery case reports, 7, pp.89–92. doi:https://doi.org/10.1016/j.ijscr.2015.01.004.
- Halpenny D, Snow A, McNeill G, Torreggiani WC. The radiological diagnosis and treatment of renal angiomyolipoma-current status. Clin Radiol. 2010;65:99–108. doi: 10.1016/j.crad.2009.09.014.
- Ljungberg, B., Bensalah, K., Canfield, S., Dabestani, S., Hofmann, F., Hora, M., Kuczyk, M.A., Lam, T., Marconi, L., Merseburger, A.S., Mulders, P., Powles, T., Staehler, M., Volpe, A. and Bex, A. (2015). EAU Guidelines on Renal Cell Carcinoma: 2014 Update. European Urology, 67(5), pp.913–924. doi:https://doi.org/10.1016/j.eururo.2015.01.005.
- Li, J., Deng, J., Tang, Z., Wang, C., Zhang, J., Lai, B., Zeng, Y., Peng, L., Chen, Q., Gao, S., Zhong, L. and Han, Y. (2025). Case report and literature review of complex renal angiomyolipoma. BMC Urology, 25(1). doi:https://doi.org/10.1186/s12894-025-01849-w.
- Flum, A.S., Hamoui, N., Said, M.A., Yang, X.J., Casalino, D.D., McGuire, B.B., Perry, K.T. and Nadler, R.B. (2016). Update on the Diagnosis and Management of Renal Angiomyolipoma. Journal of Urology, 195(4 Part 1), pp.834–846. doi:https://doi.org/10.1016/j.juro.2015.07.126.
- Zapardiel, I., Jesús Delafuente-Valero and José Bajo-Arenas (2011). Renal Angiomyolipoma during Pregnancy: Review of the Literature. Gynecologic and Obstetric Investigation, 72(4), pp.217–219. doi:https://doi.org/10.1159/000329328.
- Kutikov A, Fossett LK, Ramchandani P, Tomaszewski JE, Siegelman ES, Banner MP, et al. Incidence of benign pathologic findings at partial nephrectomy for solitary renal mass presumed to be renal cell carcinoma on preoperative imaging. Urology. 2006;68:737–740. doi: 10.1016/j.urology.2006.04.011.
- Jesper Swärd, Bohlin, K., Henrikson, O., Sven Lundstam, Peeker, R. and Bergdahl, A.G. (2025). Renal angiomyolipoma-investigating radiological signs indicative of risk for bleeding. Insights into Imaging, 16(1). doi:https://doi.org/10.1186/s13244-025-01957-z.
- Ho, T.H., Yang, F.C., Cheng, K.C., Lin, C.C. and Lee, J.T. (2019). Wunderlich syndrome, spontaneous ruptured renal angiomyolipoma and tuberous sclerosis. QJM, [online] 112(4), pp.283–284. doi:https://doi.org/10.1093/qjmed/hcz004.
- Rodríguez Collar TL, Pérez Espinosa AJ, García Gómez ML. Spontaneous retroperitoneal hemorrhage due to rupture of renal angiomyolipoma. Case Present. Havana Mag Med Sci 2016; 15: 573–581.
- Pedemonte JG, Degiovanni D, Pusterla D, et al. Lenk triad as clinical presentation of angiomyolipoma. Spanish Urol Acts 2008; 32: 850–854.
- Rodríguez Albarracín, M., Agudelo Cañon, K., Montoya Hurtado, L. and Manrique Porras, B. (2025). Spontaneous retroperitoneal hemorrhage due to rupture of a renal angiolipoma in a 37-week pregnancy: a case of Wünderlich syndrome. Obstetric Medicine. doi:https://doi.org/10.1177/1753495x251318777.
- Zhao, Y.; Yang, Z.; Xu, W.; Ji, Z.; Dong, J. Management of renal tumors during pregnancy: Case reports. BMC Nephrol. 2021, 22, 127.
- Dell’Atti, L. and Slyusar, V. (2025). Robotic Surgery in the Management of Renal Tumors During Pregnancy: A Narrative Review. Cancers, 17(4), p.574. doi:https://doi.org/10.3390/cancers17040574.
- Loughlin, K. The management of urological malignancies during pregnancy. Br. J. Urol. 1995, 76, 639–644.
- Caglayan, A.; Rabbani, R.D.; Sanchez, E.; Choi, S.; Ismail, A.; Papadopoulos, V.; Adeleke, S.; Ghose, A.; Boussios, S. Gestational Renal Cell Cancer—An Update. Anticancer Res. 2023, 43, 3871–3880.
- Akpayak, I.; Shuiabu, S.; Ofoha, C.; Dakum, N.; Ramyil, V. Renal cell carcinoma in pregnancy: Still a management challenge. Afr. J. Urol. 2015, 21, 167–170.
- Rose, T.L.; Kim, V.I. Renal cell carcinoma: A review. JAMA 2024, 332, 1001–1010.
- Amant, F.; Berveiller, P.; Boere, I.A.; Boere, I.A.; Cardonick, E.; Fruscio, R.; Fumagalli, M.; Halaska, M.J.; Hasenburg, A.; Johansson, A.L.V.; et al. Gynecologic cancers in pregnancy: Guidelines based on a third international consensus meeting. Ann. Oncol. 2019, 30, 1601–1612.
- Lee, D.; Abraham, N. Laparoscopic radical nephrectomy during pregnancy: Case report and review of the literature. J. Endourol. 2008, 22, 517–518.
- Javit, M.C. Cancer in pregnancy: Overview and epidemiology. Abdom. Radiol. 2023, 48, 1559–1563.
- Dey, S.; Pakrasi, R.; Saha, D.; Datta, S. Rapidly progressive growth of Renal Clear Cell Carcinoma and Gastrointestinal Stromal Tumor during the 3rd trimester of pregnancy: A clinical and diagnostic dilemma. Urol. Case Rep. 2021, 40, 101891.
- Dai, K.; Jiang, W.; Chen, S.; Luo, S.; Ding, S.; Wang, D. Case report: Going through pregnancy safely after twice partial nephrectomy for bilateral kidneys with HLRCC-associated RCC. Front. Oncol. 2022, 12, 932996.
- Tsutsui, K.; Miki, A.; Wakita, T.; Horibe, Y.; Tani, M.; Kakuta, Y.; Tsutahara, K.; Takao, T. A case of robot-assisted laparoscopic partial nephrectomy during pregnancy. IJU Case Rep. 2023, 6, 458–460.
Angiomyolipomas (AMLs) are uncommon, benign tumours of the kidney that can be sporadic or associated with
the Tuberous Sclerosis Complex (TSC). Individuals with AML can be asymptomatic, or present with life threatening
perirenal bleeding. An association with rapid growth during pregnancy, has been identified, thought to be resulting from
increased hormones antenatally. Having said that, existing literature lacks an established pathway in managing AML in
pregnancy. Databases including PubMed (MEDLINE) and Google Scholar were browsed until May 2025, using the below
keywords. The aim of this review article is to emphasise the importance of careful management of AML in pregnancy and
aid in establishing a clear pathway that will help in minimising risk to both mother and foetus.
Keywords :
Angiomyolipoma, Renal Angiomyolipoma, Kidney Tumour, Renal Tumour, Angiomyolipoma in Pregnancy, AML Management.