Authors :
Ayesha Sajjad; Amna Shah Mehmood; Maria Tasneem Khattak; Naveed Zaman Akhunzada; Faryal Javaid; Sana Ullah Khan; Shifa Basharat; Ayesha Safdar
Volume/Issue :
Volume 8 - 2023, Issue 3 - March
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://bit.ly/3GR8Njh
DOI :
https://doi.org/10.5281/zenodo.7811122
Abstract :
Meningioma is the most common extra-axial,
Dura-based tumor of the central nervous system. These
tumors often present in middle to late adult life,
especially in women, and account for 15% - 30% of all
intracranial tumors(1). Incidence rate of 18.69 and 0.16
per 100,000 is recorded for patients above 40 years and
0-19 years age respectively(2). The World Health
Organization (WHO) in its 2021 classification divides
meningioma into Grade I (benign), Grade II (atypical),
and Grade III (anaplastic) variants. It further subclassifies grade I meningioma into 9 subtypes:
meningothelial, fibrous, transitional, psammomatous,
angiomatous, microcystic, secretory, lymphoplasmacyte
rich, and metaplastic(3). Metaplastic meningioma is the
rarest subtype, and defined as a tumor containing focal
or widespread mesenchymal components including
osseous, cartilaginous, lipomatous, myxoid or
xanthomatous tissue, singly or in combinations(4). We
present a case of metaplastic meningioma with Myxoid,
Xanthomatous and Osseous metaplasia presenting with
anemia in a 17-year-old boy.
Keywords :
Meningioma, Anemia, Immunohistochemistry
Meningioma is the most common extra-axial,
Dura-based tumor of the central nervous system. These
tumors often present in middle to late adult life,
especially in women, and account for 15% - 30% of all
intracranial tumors(1). Incidence rate of 18.69 and 0.16
per 100,000 is recorded for patients above 40 years and
0-19 years age respectively(2). The World Health
Organization (WHO) in its 2021 classification divides
meningioma into Grade I (benign), Grade II (atypical),
and Grade III (anaplastic) variants. It further subclassifies grade I meningioma into 9 subtypes:
meningothelial, fibrous, transitional, psammomatous,
angiomatous, microcystic, secretory, lymphoplasmacyte
rich, and metaplastic(3). Metaplastic meningioma is the
rarest subtype, and defined as a tumor containing focal
or widespread mesenchymal components including
osseous, cartilaginous, lipomatous, myxoid or
xanthomatous tissue, singly or in combinations(4). We
present a case of metaplastic meningioma with Myxoid,
Xanthomatous and Osseous metaplasia presenting with
anemia in a 17-year-old boy.
Keywords :
Meningioma, Anemia, Immunohistochemistry