Method Development and Validation of Simultaneous Estimation of Etofylline, Theophylline and Montelukast in Bulk and Tablet Dosage Form by First Order Derivative UV Spectrophotometric Method

Authors : Vetrichelvan T; Murugan S; Sivakumaaran S; Anitha B; Gokulapriya A; Indhuja B; Sharmila B

Volume/Issue : Volume 8 - 2023, Issue 7 - July

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A rapid, economic, sensitive, simple and accurate first order derivative UV spectrophotometric method has been developed for estimation of Etofylline (ETO), Theophylline (THE) and Montelukast (MON) in bulk and tablet dosage form. The quantitation of selected wavelengths were 243 nm for ETO (zero cross for MON and THE), 286 nm for THE (zero cross for MON but shows absorbance in ETO) and 382 nm for MON (zero cross for ETO and THE). It obeyed beer’s law in the concentration range of 46.2-231 μg/ ml, 13.8-69 μg/ ml and 2-10 μg/ ml for ETO, THE and MON respectively. The method was validated as per ICH guidelines.

Keywords : Etofylline, Theophylline, Montelukast, First order derivative method and Tablet dosage form.


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31 - December - 2023

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