Molecular Docking Studies of Bioactive Compounds from Solenostemma Argel Leaf Extract as Potential Inhibitor for BCL-2 Antiapoptotic Proteins

Authors : Mehad Mustafa Adam Khamiss; Prakash C. Choudhary

Volume/Issue : Volume 5 - 2020, Issue 9 - September

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DOI : 10.38124/IJISRT20SEP781

This article deals with anticancer studies of phytochemicals identified from Solenostemma Argel leaf extract using GC-MS analysis and molecular docking studies. B cell lymphoma-2 (BCL-2) agonists are useful for regulating apoptosis which is essential for several cancers. The aim of the present study is to investigate the BCl-2 agonist property of phytochemicals from the extract of S. Argel using an Insilco approach. The docking on human BCL-2 protein was determined by GOLD 3.0.1 software. It is concluded from the studies that compound suggested by GCMS at RT 17.1 minute is 4,5,7-trihydroxy isoflavone showed best result with highest fitness index

Keywords : Cancer; Docking studies; BCL-2; Solenostemma argel


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