Authors :
Chitra Janardan Chavan; Trushali A Mandhare
Volume/Issue :
Volume 9 - 2024, Issue 5 - May
Google Scholar :
https://tinyurl.com/4jx9anay
Scribd :
https://tinyurl.com/3pndy9n6
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24MAY2513
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
The antipsychotic drug Clozapine is widely
recognized for its efficacy in treating resistant
schizophrenia. This study aims to elucidate the binding
interactions of Clozapine with four key proteins: 1GQ1,
1MKF, 4OAJ, and 7WU2. These proteins represent
diverse biological targets, including receptors and
enzymes relevant to neurological function and drug
metabolism. Utilizing molecular docking simulations, we
compared the binding affinities and interaction profiles of
Clozapine with these proteins.
References :
- Albitar, Orwa, et al. "Population pharmacokinetics of clozapine: a systematic review." BioMed research international 2020 (2020).
- Jann, Michael W., et al. "Pharmacokinetics and pharmacodynamics of clozapine." Clinical pharmacokinetics 24 (1993): 161-176.
- Meltzer, Herbert Y. "An overview of the mechanism of action of clozapine." The journal of clinical psychiatry 55 (1994): 47-52.
- Ramírez, David, and Julio Caballero. "Is it reliable to use common molecular docking methods for comparing the binding affinities of enantiomer pairs for their protein target." International journal of molecular sciences 17.4 (2016): 525.
- Olagunju, Andrew T., Scott R. Clark, and Bernhard T. Baune. "Clozapine and psychosocial function in schizophrenia: a systematic review and meta-analysis." CNS drugs 32.11 (2018): 1011-1023.
- https://openai.com/share/b5e8170f-5fc2-4cf6-a597-adda4e4f8840
The antipsychotic drug Clozapine is widely
recognized for its efficacy in treating resistant
schizophrenia. This study aims to elucidate the binding
interactions of Clozapine with four key proteins: 1GQ1,
1MKF, 4OAJ, and 7WU2. These proteins represent
diverse biological targets, including receptors and
enzymes relevant to neurological function and drug
metabolism. Utilizing molecular docking simulations, we
compared the binding affinities and interaction profiles of
Clozapine with these proteins.