Nanotechnology is emerging as new implementations that can be used directly or indirectly to combat lethal bacterial infections & surmount antibiotic resistance. Antibiotic overuse is on the rise due to factors including an ageing population, a rise in infectious illnesses, & the frequency of chronic conditions that need their treatment. The broad distribution of resistance genes at an environmental scale may be traced back to the extra & inadvisable utilisation of antibiotics by humans, which has led to the rise of bacteria resistance to existing antibiotics & the selective growth of other microbes. The widespread dissemination of resistance & the transfer of resistance genes across bacterial species resulted in the appearance of multidrug-resistant (MDR) pathogens. This concern is exacerbated by the formation of biofilms by microorganisms, which can increase bacterial resistance by up to a factor of 1,000 & promote a rise of MDR infections. Therefore, the purpose of the study is to review nanotechnology as a potential method for combating MDR bacteria: a comprehensive analysis & future prospects. The methodologies are discussed based on secondary sources (websites, Google Scholar & various internet sources). This research demonstrated that AgNPs are extremely potent nanoparticles (NPs) for the treatment of MDR bacteria. Antibacterial activity of Ag NPs was shown, & their efficacy against MDR bacteria was confirmed. In conclusion, the biosynthesis of pure Ag NPs with significant antibacterial MDR action seems to be a step in the right direction, thanks to this innovative approach.

Keywords : Multi Drug Resistant Bacteria, Antibacterial Activity, Nanotechnology.