Adenosquamous carcinoma (ASC) is a rare type of squamous cell carcinoma (SCC). It is known to be more aggressive. It is not commonly described in the literature with very little cases reporting tumor’s diagnosis features and outcomes. We report an unusual location of the tumor in the nasal pyramid skin. Case presentation: A 57- year-old man presented a chronic enormous painless mass of the nasal pyramid evolving for 4 months, associated with unilateral left nose bleeding and nasal obstruction. The clinical examination finds an ulcerative bulging mass of the left part of the nasal pyramid reaching out the other side. The biopsy specimen of the mass showed mucoepidermoid carcinoma. The patient underwent surgical excision of the tumor.Microscopically, thehistopathological examination of the operative specimen had combined features of squamous carcinoma and adenocarcinoma components. Perineural and vascular invasion were present. The patient subsequently underwent adjuvant treatment radiotherapy and chemotherapy with no evidence of local recurrence or regional metastasis. Conclusion: Adenosquamous carcinoma is uncommon and aggressive tumor. All clinicians should keep in mind when treating patients with ASC of head and neck, that they have to consider the tumor as being on the most aggressive form compared to conventional SCC with higher tendency of disease recurrences, distant and lymph node metastases.

Keywords : Adenosquamous carcinoma, head and neck,mucoepidermoid carcinoma, nasal carcinoma. Adeno squamous carcinoma (ASC), squamous cell carcinoma (SCC), mucoepidermoid carcinoma (MEC)