Observational Study on Effect of Age on Number of Oocyte Retrieval when Human Menopausal Gonadotropins is being given in Women Undergoing IVF


Authors : Prem Patel

Volume/Issue : Volume 10 - 2025, Issue 1 - January

Google Scholar : https://tinyurl.com/y3m8ae2h

Scribd : https://tinyurl.com/6vwv65df

DOI : https://doi.org/10.5281/zenodo.14709616

Abstract : Assisted reproductive technologies, specifically in vitro fertilization (IVF), have revolutionized fertility treatments, offering hope to couples facing challenges in conceiving naturally. Within the context of IVF, Human Menopausal Gonadotropin (hMG) plays a crucial role in ovarian stimulation, promoting the development of multiple follicles and increasing the likelihood of successful oocyte retrieval. However, the impact of age on the ovarian response to hMG stimulation is well- documented, with aging women often exhibiting altered patterns of follicular growth and hormonal dynamics. Advanced maternal age is associated with a decline in ovarian reserve and diminished oocyte quality, potentially influencing the outcomes of IVF cycles. This study aims to fill this knowledge gap by meticulously investigating how age influences ovarian response during IVF cycles with hMG, providing valuable insights to inform personalized and optimized fertility treatment protocols for women across different age groups. Retrospective analysis of 113 women aged 26-45 undergoing IVF with hMG at selected site in period of 3 months. Extracting relevant data from patient records, including age, baseline hormones, stimulation details, AFC count, and oocyte retrieval. The obtained data was analysed by descriptive analysis (ANOVA) using Ms excel. An overview of the oocyte yield for every age group may be seen in the average total oocyte count. According to the data, the mean number gradually decreases with age, which is consistent with aging-related decreases in follicular response and ovarian reserve. The study shows that the 26-30 age group had the highest number of oocytes while oocyte Numbers in the age groups of 31–35, 36–40, and 41–45 indicate a consistent age-related drop in the total oocyte retrieval count. This reduction occurs as a result of aging-related declines in ovarian reserve and follicular quality, which lessen the ovarian response to stimulation during IVF treatment.

Keywords : IVF, Human Menopausal Gonadotropin (hMG), Oocyte, Age, AFC, Infertility.

References :

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  37. Te Velde ER, Pearson PL. The variability of female reproductive ageing. Hum Reprod Update. 2002 Mar-Apr;8(2):141-54.
  38. Sunkara SK, Rittenberg V, Raine-Fenning N, Bhattacharya S, Zamora J, Coomarasamy A. Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles. Hum Reprod. 2011 Jul;26(7):1768-74.
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Assisted reproductive technologies, specifically in vitro fertilization (IVF), have revolutionized fertility treatments, offering hope to couples facing challenges in conceiving naturally. Within the context of IVF, Human Menopausal Gonadotropin (hMG) plays a crucial role in ovarian stimulation, promoting the development of multiple follicles and increasing the likelihood of successful oocyte retrieval. However, the impact of age on the ovarian response to hMG stimulation is well- documented, with aging women often exhibiting altered patterns of follicular growth and hormonal dynamics. Advanced maternal age is associated with a decline in ovarian reserve and diminished oocyte quality, potentially influencing the outcomes of IVF cycles. This study aims to fill this knowledge gap by meticulously investigating how age influences ovarian response during IVF cycles with hMG, providing valuable insights to inform personalized and optimized fertility treatment protocols for women across different age groups. Retrospective analysis of 113 women aged 26-45 undergoing IVF with hMG at selected site in period of 3 months. Extracting relevant data from patient records, including age, baseline hormones, stimulation details, AFC count, and oocyte retrieval. The obtained data was analysed by descriptive analysis (ANOVA) using Ms excel. An overview of the oocyte yield for every age group may be seen in the average total oocyte count. According to the data, the mean number gradually decreases with age, which is consistent with aging-related decreases in follicular response and ovarian reserve. The study shows that the 26-30 age group had the highest number of oocytes while oocyte Numbers in the age groups of 31–35, 36–40, and 41–45 indicate a consistent age-related drop in the total oocyte retrieval count. This reduction occurs as a result of aging-related declines in ovarian reserve and follicular quality, which lessen the ovarian response to stimulation during IVF treatment.

Keywords : IVF, Human Menopausal Gonadotropin (hMG), Oocyte, Age, AFC, Infertility.

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Paper Submission Last Date
30 - June - 2025

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