Authors :
Abdisamed Abdi Ali; Dr. Yemisirach Bizuneh; Dr. Bethelehem Yesehak
Volume/Issue :
Volume 11 - 2026, Issue 4 - April
Google Scholar :
https://tinyurl.com/mryass3m
Scribd :
https://tinyurl.com/ychc6web
DOI :
https://doi.org/10.38124/ijisrt/26apr257
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Background:
Ventriculitis is associated with high mortality and negatively affects the prognosis of neurosurgical patients. Procedures
that can lead to post-neurosurgical ventriculitis include craniotomy, EVD, ventriculostomy, lumbar puncture, and VP shunt
insertion.The management of ventriculitis can be lengthy and expensive and ventriculitis can lead to serious long-term
sequelae and even result in death.Therefore, early diagnosis, identification of the pathogen, and time to initiation of adequate
antibiotic therapy are important variables that can improve the clinical outcomes of ventriculitis in children.
Objective:
Assessment of the outcome of pediatric patients treated for ventriculitis at Zewditu memorial hospital.
Keywords :
Ventriculitis, Children, Outcome, ZMH.
References :
- Luque-Paz, D.; Revest, M.; Eugène, F.; Boukthir, S.; Dejoies, L.; Tattevin, P.; Le Reste, P.-J. Ventriculitis: A Severe Complication of Central Nervous System Infections. Open Forum Infect. Dis. 2021, 8, ofab216.
- Tunkel, A.R.; Hasbun, R.; Bhimraj, A.; Byers, K.; Kaplan, S.L.; Scheld, W.M.; van de Beek, D.; Bleck, T.P.; Garton, H.J.L.; Zunt, J.R. 2017 Infectious Diseases Society of America’s Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin. Infect. Dis. 2017, 64, e34–e65.
- Citerio, G.; Signorini, L.; Bronco, A.; Vargiolu, A.; Rota, M.; Latronico, N. External ventricular and lumbar drain device infections in icu patients: A prospective multicenter Italian study. Crit. Care Med. 2015, 43, 1630–1637.
- Hazany S, Go JL, Law M. Magnetic resonance imaging of infectious meningitis and ventriculitis in adults. Top Magn Reson Imaging 2014; 23:315–25.
- Harris L, Munakomi S. Ventriculitis. StatPearls. Treasure Island, FL: StatPearls Publishing; 2020.
- Tunkel AR, Hasbun R, Bhimraj A, et al. 2017 Infectious Diseases Society of America’s Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis 2017; 64:e34–65.
- Bijlsma MW, Brouwer MC, Kasanmoentalib ES, et al. Community-acquired bacterial meningitis in adults in the Netherlands, 2006–14: a prospective cohort study. Lancet Infect Dis 2016; 16:339–47.
- ((Humphreys H, Jenks PJ. Surveillance and management of ventriculitis following neurosurgery. Journal of Hospital Infection. 2015. Available from: https://www.journalofhospitalinfection.com/article/ S0195-6701(15)00051-1/fulltext DOI: 10.1016/j.jhin.2014.12.019..
- Tunkel AR, Hasbun R, Bhimraj A, Byers K, Kaplan SL, Scheld WM, et al. 2017 Infectious Diseases Society of Infectious Diseases. 2017; 64(6): p. e34-e65. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/P MC5848239/pdf/ciw861.pdf DOI:10.1093/cid/ciw861.
- Beer R, Lackner P, Pfausler B, Schmutzhard E. Nosocomial ventriculitis and meningitis in neurocritical care patients. Journal of Neurology. 2008; 255. Available from:https://link.springer.com/article/10.1007%2Fs 00415-008-0059-8 DOI: 10.1007/s00415-008-0059-8.
- Spennato P, Mirone G, Cicala D, Ruggiero C, Di Martino G, De Caro ML, et al. Pathophysiology and treatment of multiloculated hydrocephalus. In: Cinalli G, editor. Pediatric hydrocephalus. Milan, Italy: Springer, 2019. p. 855-905.
- Zuccaro G, Ramos JG. Multiloculated hydrocephalus. Childs Nerv Syst 2011;27:1609-19.
- Wang, X.; Dong, Y.; Qi, X.Q.; Li, Y.M.; Huang, C.G.; Hou, L.J. Clinical review: Efficacy of antimicrobial-impregnated catheters in external ventricular drainage—A systematic review and meta-analysis. Crit. Care 2013, 17, 6–10.
- Harris, L.; Munakomi, S. Ventriculitis. StatPearls 2021, 1–8. Available online: https://www.ncbi.nlm.nih.gov/books/NBK544332/ (accessed on 4 August 2021.
- Mallucci, C.L.; Jenkinson, M.D.; Conroy, E.J.; Hartley, J.C.; Brown, M.; Dalton, J.; Kearns, T.; Moitt, T.; Griffiths, M.J.;Culeddu, G.; et al. Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): A multicentre, single-blinded,randomised trial and economic evaluation. Lancet 2019, 394, 1530–1539.
- Tunkel AR, Hasbun R, Bhimraj A, Byers K, Kaplan S, Scheld M,et al. 2017 Infectious Diseases Society of America’s ClinicalPractice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis 2017;64:e34.
- Phan K, Schultz K, Huang C, Halcrow S, Fuller J, McDowell D,et al. External ventricular drain infections at the Canberra Hospital: A retrospective study. J Clin Neurosci2016;32:95e8.
- Patwardhan RV. Nanda A Implanted ventricular shunts in the United States: the billiondollar-a-year cost of hydrocephalus treatment. Neurosurgery 2005;56:139e45.
- Gudina EK, Tesfaye M, Adane A, Lemma K, Shibiru T, Wieser A, et al. Adjunctive dexamethasone therapy in unconfirmed bacterial meningitis in resource limited settings: is it a risk worth taking? BMC Neurol. 2016;16(1):1–8. https://doi.org/10.1186/s12883-016-0678-0.
- Wall EC, Cartwright K, Scarborough M, Ajdukiewicz KM, Goodson P, Mwambene J, et al. High mortality amongst adolescents and adults with bacterial meningitis in sub-Saharan Africa: an analysis of 715 cases from Malawi. PLoS One. 2013;8(7):e69783. https://doi.org/10.1371/journal.pone.0069783.
- Teixeira DC, Diniz LMO, Guimarães NS, Moreira HMdAS, Teixeira CC,RomanelliRMdC. Risk factors associated with the outcomes of pediatric bacterial meningitis: a systematic review. J Pediatr 2020;96(2):159–167, DOI:https://doi.org/10.1016/j.jped.2019.07.003.
- Acho H. Childhood bacterial meningitis: antimicrobial use pattern and treatment outcomes in Jimma university specialized hospital, Southwest Ethiopia; 2015.
- Tewabe T, Fenta A, Tegen A, Mezgebu M, Fentie T, Zeleke T. Clinical outcomes and risk factors of meningitis among children in referral hospital, Ethiopia, 2016: a retrospective chart review. Ethiopian J Health Sci. 2018; 28(5).
- Martin C, Thomachot L, Albanèse J. Iatrogenic and traumatic cerebro-meningeal infections. Rev Prat. 1994;44(16):2207–2212.
- Eljamel MS. Antibiotic prophylaxis in unrepaired CSF fistulae. Br J Neurosurg. 1993;7(5):501–505.
- Buckwold FJ, Hand R, Hansebout RR. Hospital-acquired bacterial meningitis in neurosurgical patients. J Neurosurg. 1977;46(4):494–500.
- Lai WA, Lu CH, Chang WN. Mixed infection in adult post-neurosurgical bacterial meningitis: a hospital-based study. Biomed J. 2013;36(6):295–303
- Daniel Lilley, Peter Munthali. Analysis of the management of ventriculitis cases at a UK neurosurgery center. Infection Prevention in Practice 4 (2022) 100240.
- ChanunyaSrihawan, Rodrigo Lopez Castelblanco, Lucrecia Salazar, Susan H. Wootton,Elizabeth Aguilera, Luis Ostrosky-Zeichner, David I. Sandberg, HuiMahn A. Choi,Kiwon Lee, Ryan Kitigawa, Nitin Tandon, and Rodrigo Hasbun. Clinical Characteristics and Predictors of Adverse Outcome in Adult and Pediatric Patients with Healthcare-Associated Ventriculitis and Meningitis.2016. infectious disease society of America. DOI: 10.1093/ofid/ofw077.
- Doriam Perera MD; Edgar Herrera MD; Luis Zapata MD; José Hurtado MD; Karen Herrera PhD. Systematic review and meta-analysis of intraventricular antibiotics for neonatal meningitis and ventriculitis.2023. doi: https://doi.org/10.1101/2023.09.07.23295218.
- Ahmed Al Menabbawy, MBBCh, Ehab El Refaee, Mohamed A. R. Soliman, Mohamed A. Elborady, Mohamed A. Katri, Steffen Fleck, Henry W. S. Schroeder, and Ahmed Zohdi. Outcome improvement in cerebral ventriculitis after ventricular irrigation: a prospective controlled study. J NeurosurgPediatr 26:682–690, 2020.
- FuMei Chen1, Xianyu Deng, Zhanpeng Wang, Li Wang, Ke Wang and Liang Gao. Treatment of severe ventriculitis caused by extensively drug-resistant Acinetobacter baumannii by intraventricular lavage and administration of colistin. Infection and Drug Resistance 2019:12 241–247.
- ChanunyaSrihawan, Rodrigo Lopez Castelblanco, Lucrecia Salazar, Susan H. Wootton, Elizabeth Aguilera, Luis Ostrosky-Zeichner, David I. Sandberg, HuiMahn A. Choi, Kiwon Lee, Ryan Kitigawa, Nitin Tandon, and Rodrigo Hasbun. Clinical Characteristics and Predictors of Adverse Outcome in Adult and Pediatric Patients With Healthcare-Associated Ventriculitis and Meningitis. 2016. Infectious disease society of America. DOI: 10.1093/ofid/ofw077.
- Hussain K, Sohail Salat M, Ambreen G and Iqbal J (2021) Neurodevelopment Outcome of Neonates Treated With Intraventricular Colistin for Ventriculitis Caused by Multiple Drug-Resistant Pathogens—A Case Series. Front. Pediatr. 8:582375.doi: 10.3389/fped.2020.582375.
- Francesca Mae T. Pantig, MD, Anna Lisa T. Ong-Lim, MD. intraventricular antimicrobial therapy in children with multi-drug resistant ventriculitis: a tertiary hospital experience and literature review. Pediatric Infectious Disease Society of the Philippines Journal. Vol 20 No 2 pp.47-56 July-December 2019.
Background:
Ventriculitis is associated with high mortality and negatively affects the prognosis of neurosurgical patients. Procedures
that can lead to post-neurosurgical ventriculitis include craniotomy, EVD, ventriculostomy, lumbar puncture, and VP shunt
insertion.The management of ventriculitis can be lengthy and expensive and ventriculitis can lead to serious long-term
sequelae and even result in death.Therefore, early diagnosis, identification of the pathogen, and time to initiation of adequate
antibiotic therapy are important variables that can improve the clinical outcomes of ventriculitis in children.
Objective:
Assessment of the outcome of pediatric patients treated for ventriculitis at Zewditu memorial hospital.
Keywords :
Ventriculitis, Children, Outcome, ZMH.