Hydroxyzine a pharmaceutical used as
antihistamine is oxidized with potassium permanganate
to study its kinetics at various temperatures. The rate of
reaction was observed is first order with respect to
substrate and oxidant whereas it is independent on acid
medium. There is no effect of salt on the rate of reaction
and no polymerization initiated during the reaction. The
final product obtained is identified as hydroxyzine Noxide. The suitable mechanism is proposed and rate law
is derived
Keywords :
Oxidation, Mechanism, Hydroxyzine, Kinetics, Acid.