Authors :
Andri Putranda Aswar; IchwanulAdenin; Binarwan Halim; M. Fidel GanisSiregar; M. Rusda; M. OkyPrabudi
Volume/Issue :
Volume 7 - 2022, Issue 10 - October
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3Nsjgnk
DOI :
https://doi.org/10.5281/zenodo.7270580
Abstract :
In vitro fertilization has not shown a
significant increase in success rates, especially in low and
hypo-responders. One of the causes is oxidative stress.
This study aims to determine the relationship between
level of ROS, TAC and ROS-TAC score in follicular
fluid with oocyte maturity rate, oocyte quality rate,
fertilization rate and embryo quality rate in low and
hypo-responder patients.
Methods: An analytical observational study with a
prospective cohort design conducted at Halim Fertility
Center (HFC), Stella Maris Hospital, IVF Clinic,
Division of Fertility Endocrinology Reproduction,
Department of Obstetrics and Gynecology, USU Medical
Faculty, Medan, from April 2021 until the number of
samples is met.
Results: This study was followed by 84 patients. 33
patients from Poseidon 1 (P1) group, 30 patients from
P2, 12 patients from P3 and 9 patients from P4. There
was no significant difference based on the demographic
characteristics of each group, except for age (p<0.001),
duration of infertility and duration of stimulation
(p<0.001 and p=0.004). The highest ROS level was in the
P1 group with a mean of 462.92. There was a significant
difference in the mean ROS levels between the four
groups (p=0.049). There was no significant difference in
TAC and ROS-TAC levels in the four groups (p=0.524)
and (p=0.460). A significant correlation was found
(r=0.458) between the TAC level and the rate of embryo
quality in the P1 group (p=0.007). There was no
significant difference in each poseidon group between
ROS, TAC and ROS-TAC scores with oocyte maturity
rate, oocyte quality rate, fertilization rate and embryo
quality rate in hypo-responders.
Conclusion: ROS was significantly highest in the P1
group while TAC was significantly correlated with the
rate of embryo quality also in the P1 group. Further
research is needed to see the relationship between ROS,
TAC and ROS-TAC score with oocyte quality, embryo
and IVF success.
Keywords :
In vitro fertilization, Hypo-responder, Lowresponder, Oocyte, Oxidative stress, ROS, TAC, ROS-TAC score, POSEIDON.
In vitro fertilization has not shown a
significant increase in success rates, especially in low and
hypo-responders. One of the causes is oxidative stress.
This study aims to determine the relationship between
level of ROS, TAC and ROS-TAC score in follicular
fluid with oocyte maturity rate, oocyte quality rate,
fertilization rate and embryo quality rate in low and
hypo-responder patients.
Methods: An analytical observational study with a
prospective cohort design conducted at Halim Fertility
Center (HFC), Stella Maris Hospital, IVF Clinic,
Division of Fertility Endocrinology Reproduction,
Department of Obstetrics and Gynecology, USU Medical
Faculty, Medan, from April 2021 until the number of
samples is met.
Results: This study was followed by 84 patients. 33
patients from Poseidon 1 (P1) group, 30 patients from
P2, 12 patients from P3 and 9 patients from P4. There
was no significant difference based on the demographic
characteristics of each group, except for age (p<0.001),
duration of infertility and duration of stimulation
(p<0.001 and p=0.004). The highest ROS level was in the
P1 group with a mean of 462.92. There was a significant
difference in the mean ROS levels between the four
groups (p=0.049). There was no significant difference in
TAC and ROS-TAC levels in the four groups (p=0.524)
and (p=0.460). A significant correlation was found
(r=0.458) between the TAC level and the rate of embryo
quality in the P1 group (p=0.007). There was no
significant difference in each poseidon group between
ROS, TAC and ROS-TAC scores with oocyte maturity
rate, oocyte quality rate, fertilization rate and embryo
quality rate in hypo-responders.
Conclusion: ROS was significantly highest in the P1
group while TAC was significantly correlated with the
rate of embryo quality also in the P1 group. Further
research is needed to see the relationship between ROS,
TAC and ROS-TAC score with oocyte quality, embryo
and IVF success.
Keywords :
In vitro fertilization, Hypo-responder, Lowresponder, Oocyte, Oxidative stress, ROS, TAC, ROS-TAC score, POSEIDON.
