Temporomandibular joint pain issues are the most common chronic orofacial pain conditions that dentists and other medical practitioners must treat. The causes of temporomandibular disorders include a multitude of predisposing, activating, and perpetuating variables as well as muscular hyperactivity, trauma, mental stress, and malocclusion. It is possible to use and effective non-pharmacological treatment method known as ozone oil therapy to treat temporomandibular joint pain disorder. You may use ozone in the form of petrol, water, or oil. It has anti-inflammatory and analgesic effects because of its ability to oxidise double bond compounds such arachidonic acid and its derivatives that are present at the inflammatory sites and so resolve pH. It has analgesic qualities, which lessen pain, due to its ability to oxidise albuminolysis byproducts and act on nerve terminals in inflamed tissue.